Journal
FOODS
Volume 11, Issue 17, Pages -Publisher
MDPI
DOI: 10.3390/foods11172703
Keywords
gut microbiota; nutrient; short-chain fatty acid; gut-liver axis; metabolites
Categories
Funding
- Hallym University Research Fund
- Basic Science Research Program through the National Research Foundation of Korea - Ministry of Education, Science and Technology [NRF-2020R1I1A3073530, NRF-2020R1A6A1A03043026]
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Diet and lifestyle are crucial factors that affect the occurrence of NAFLD. Personalized diet patterns can influence the composition and activity of gut microbiota, exacerbating NAFLD via the gut-liver axis. Advances in diagnostic technology have improved the diagnosis, treatment, and prognosis of NAFLD. Microbiota-derived metabolites play a significant role in the pathogenesis of NAFLD.
Diet and lifestyle are crucial factors that influence the susceptibility of humans to nonalcoholic fatty liver disease (NAFLD). Personalized diet patterns chronically affect the composition and activity of microbiota in the human gut; consequently, nutrition-related dysbiosis exacerbates NAFLD via the gut-liver axis. Recent advances in diagnostic technology for gut microbes and microbiota-derived metabolites have led to advances in the diagnosis, treatment, and prognosis of NAFLD. Microbiota-derived metabolites, including tryptophan, short-chain fatty acid, fat, fructose, or bile acid, regulate the pathophysiology of NAFLD. The microbiota metabolize nutrients, and metabolites are closely related to the development of NAFLD. In this review, we discuss the influence of nutrients, gut microbes, their corresponding metabolites, and metabolism in the pathogenesis of NAFLD.
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