Effect of fetoscopic laser surgery on the placental characteristics and birth-weight discordance of twins with twin-to-twin transfusion syndrome

ObjectiveThis study explored the effect of fetoscopic laser surgery on the placental structure and birth-weight discordance of twin-to-twin transfusion syndrome (TTTS). MethodsA retrospective cohort study was conducted in TTTS patients who were admitted to the Peking University Third Hospital between April 2014 and April 2020. The patients were divided into two groups: laser group and control group. Placentas with twin survival were injected, and pregnancy outcomes and placental characteristics of the two groups were compared. The correlation between the birth-weight discordance and placental characteristics in each group was analyzed. ResultsThe gestational age at first diagnosis in the laser group was significantly smaller than that in the control group (21.6 +/- 2.8 weeks vs. 27.7 +/- 3.0 weeks, p < 0.001). The proportion of patients with TTTS stage-I in the laser group was significantly lower than the control group (9.4 vs. 64.0%, p < 0.001). The gestational age at delivery in the laser group was significantly larger than that in the control group (33.6 +/- 2.1 weeks vs. 31.4 +/- 2.5 weeks, p = 0.001). In the laser group, the birth-weight discordance ratio was positively correlated with the placental territory discordance ratio (Spearman coefficient = 0.556; p = 0.001). ConclusionThe birth-weight discordance is positively correlated with placental territory discordance in TTTS patients after FLS.

Automated summary

This study investigated the impact of fetoscopic laser surgery on TTTS patients and found that the laser group had significantly improved gestational age, TTTS stage, and delivery gestational age compared to the control group. Furthermore, in the laser group, there was a positive correlation between birth-weight discordance and placental territory discordance.