Journal
FRONTIERS IN MEDICINE
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fmed.2022.995882
Keywords
colorectal cancer; cancer stem cell; chemotherapy resistance; stem cells; reverse
Categories
Funding
- Financial Department of Jilin Province
- [JLSCZT2019-018]
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This study reviews the mechanisms of chemotherapy resistance in colorectal cancer (CRC), primarily focusing on cancer stem cells (CSCs). The research also discusses potential strategies to overcome chemotherapy resistance and eliminate CSCs, providing promising insights for CRC treatment.
Tumor recurrence and chemotherapy resistance are mainly responsible for poor prognosis in colorectal cancer (CRC) patients. Cancer stem cell (CSC) has been identified in many solid tumors, including CRC. Additionally, CSC cannot be completely killed during chemotherapy and develops resistance to chemotherapeutic drugs, which is the main reason for tumor recurrence. This study reviews the main mechanisms of CSC chemotherapy resistance in CRC, including activation of DNA damage checkpoints, epithelial-mesenchymal transition (EMT), inhibition of the overexpression of antiapoptotic regulatory factors, overexpression of ATP-binding cassette (ABC) transporters, maintenance of reactive oxygen species (ROS) levels, and the dormant state of CSC. Advances in research to reverse chemotherapy resistance are also discussed. Our study can provide the promising potential for eliminating CSC and preventing tumor progression for CRC treatment.
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