4.6 Article

Effects of rich cannabidiol oil on behavioral disturbances in patients with dementia: A placebo controlled randomized clinical trial

Related references

Note: Only part of the references are listed.
Article Chemistry, Analytical

Safety, Pharmacokinetics and Pharmacodynamics of Spectrum Yellow Oil in Healthy Participants

Erica N. Peters et al.

Summary: This study evaluated the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of Spectrum Yellow oil, a cannabis product used for medical purposes. The results showed that Spectrum Yellow oil had good safety and tolerability at appropriate doses, with steady-state plasma CBD concentrations reached within 7 days.

JOURNAL OF ANALYTICAL TOXICOLOGY (2022)

Article Pharmacology & Pharmacy

A placebo-controlled investigation of the analgesic effects, abuse liability, safety and tolerability of a range of oral cannabidiol doses in healthy humans

Caroline A. Arout et al.

Summary: This study found that acute oral CBD did not consistently demonstrate dose-dependent analgesic effects in healthy noncannabis users, and in fact increased pain in some measures. Future studies should consider using more comprehensive pain assessment paradigms and investigate the analgesic effects of CBD in different populations.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2022)

Article Geriatrics & Gerontology

Mortality in patients with behavioural and psychological symptoms of dementia: a registry-based study

Vanja Bransvik et al.

Summary: This study explores the impact of BPSD on mortality in severe dementia, showing that moderate or severe BPSD is associated with an increased risk of mortality. Additionally, there is a correlation between total NPI score and mortality.

AGING & MENTAL HEALTH (2021)

Article Genetics & Heredity

Cannabinoid treatment for autism: a proof-of-concept randomized trial

Adi Aran et al.

Summary: A placebo-controlled double-blind study compared two oral cannabinoid solutions in 150 participants with ASD, showing that the whole-plant extract was more effective in improving disruptive behavior compared to placebo. However, there were no significant differences in other behavioral issues and parental stress.

MOLECULAR AUTISM (2021)

Article Psychiatry

Behavioral aspects and neurobiological properties underlying medical cannabis treatment in Shank3 mouse model of autism spectrum disorder

Shani Poleg et al.

Summary: This study investigates the effects of long-term oral treatment with CBD-enriched medical cannabis oil on a human mutation-based Shank3 mouse model of ASD. The treatment was found to alleviate anxiety and decrease repetitive grooming behavior in mutant mice. The involvement of CB1 receptor signaling in the mechanism of Avidekel oil, alongside a decrease in cerebrospinal fluid glutamate concentrations, was uncovered. RNA sequencing of cerebellar brain samples post-treatment revealed changes in mRNA expression of neurotransmission-related genes. The relevance of CBD enrichment and the importance of the THC component in treating core symptoms of ASD were highlighted.

TRANSLATIONAL PSYCHIATRY (2021)

Article Gastroenterology & Hepatology

Oral CBD-rich Cannabis Induces Clinical but Not Endoscopic Response in Patients with Crohn's Disease, a Randomised Controlled Trial

Timna Naftali et al.

Summary: This study evaluated the effects of CBD-rich cannabis oil on inducing remission in patients with Crohn's disease. Results showed significant clinical improvement and quality of life enhancement without notable changes in inflammatory markers or endoscopic scores in the CBD group compared to the placebo group.

JOURNAL OF CROHNS & COLITIS (2021)

Review Medicine, General & Internal

Antipsychotics for agitation and psychosis in people with Alzheimer's disease and vascular dementia

Viktoria Muehlbauer et al.

Summary: There is some evidence that typical antipsychotics might decrease agitation and psychosis slightly in patients with dementia. Atypical antipsychotics reduce agitation in dementia slightly, but their effect on psychosis in dementia is negligible. Both drug classes increase the risk of somnolence and other adverse events.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2021)

Review Medicine, General & Internal

Cannabinoids for the treatment of dementia

Dina Bosnjak Kuharic et al.

Summary: Based on data from four small, short, and heterogeneous placebo-controlled trials, it is uncertain whether cannabinoids have any beneficial or harmful effects on dementia. If there are benefits of cannabinoids for people with dementia, the effects may be too small to be clinically meaningful. Adequately powered, methodologically robust trials with longer follow-up are needed to properly assess the effects of cannabinoids in dementia.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2021)

Review Pharmacology & Pharmacy

Clinical Data for the Use of Cannabis-Based Treatments: A Comprehensive Review of the Literature

Shannon Inglet et al.

ANNALS OF PHARMACOTHERAPY (2020)

Review Biochemistry & Molecular Biology

Cannabidiol: A Potential New Alternative for the Treatment of Anxiety, Depression, and Psychotic Disorders

Maria S. Garcia-Gutierrez et al.

BIOMOLECULES (2020)

Article Geriatrics & Gerontology

Randomized Placebo-Controlled Trial of Nabilone for Agitation in Alzheimer's Disease

Nathan Herrmann et al.

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY (2019)

Article Multidisciplinary Sciences

Real life Experience of Medical Cannabis Treatment in Autism: Analysis of Safety and Efficacy

Lihi Bar-Lev Schleider et al.

SCIENTIFIC REPORTS (2019)

Review Pharmacology & Pharmacy

Safety and effectiveness of cannabinoids for the treatment of neuropsychiatric symptoms in dementia: a systematic review

Jodie Belinda Hillen et al.

THERAPEUTIC ADVANCES IN DRUG SAFETY (2019)

Article Medicine, General & Internal

Prospective analysis of safety and efficacy of medical cannabis in large unselected population of patients with cancer

Lihi Bar-Lev Schleider et al.

EUROPEAN JOURNAL OF INTERNAL MEDICINE (2018)

Article Medicine, General & Internal

Epidemiological characteristics, safety and efficacy of medical cannabis in the elderly

Ran Abuhasira et al.

EUROPEAN JOURNAL OF INTERNAL MEDICINE (2018)

Review Biochemistry & Molecular Biology

Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System

Shenglong Zou et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Clinical Neurology

Medical Cannabis for Pediatric Moderate to Severe Complex Motor Disorders

Stephanie Libzon et al.

JOURNAL OF CHILD NEUROLOGY (2018)

Review Psychology, Clinical

Causes of nursing home placement for older people with dementia: a systematic review and meta-analysis

Sandeep Toot et al.

INTERNATIONAL PSYCHOGERIATRICS (2017)

Review Biochemistry & Molecular Biology

Endocannabinoid system in neurodegenerative disorders

Balapal S. Basavarajappa et al.

JOURNAL OF NEUROCHEMISTRY (2017)

Article Medicine, General & Internal

Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome

Orrin Devinsky et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Review Pharmacology & Pharmacy

Cannabidiol: State of the art and new challenges for therapeutic applications

Simona Pisanti et al.

PHARMACOLOGY & THERAPEUTICS (2017)

Article Clinical Neurology

CBD-enriched medical cannabis for intractable pediatric epilepsy The current Israeli experience

Michal Tzadok et al.

SEIZURE-EUROPEAN JOURNAL OF EPILEPSY (2016)

Article Geriatrics & Gerontology

Management of the behavioral and psychological symptoms of dementia

Elizabeth Hersch

Clinical Interventions in Aging (2016)

Article Geriatrics & Gerontology

Tetrahydrocannabinol in Behavioral Disturbances in Dementia: A Crossover Randomized Controlled Trial

Geke A. H. van den Elsen et al.

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY (2015)

Article Psychology, Clinical

Change in agitation in Alzheimer's disease in the placebo arm of a nine-week controlled trial

Paul B. Rosenberg et al.

INTERNATIONAL PSYCHOGERIATRICS (2015)

Article Clinical Neurology

Tetrahydrocannabinol for neuropsychiatric symptoms in dementia A randomized controlled trial

Geke A. H. van den Elsen et al.

NEUROLOGY (2015)

Review Clinical Neurology

Molecular Targets of Cannabidiol in Neurological Disorders

Clementino Ibeas Bih et al.

NEUROTHERAPEUTICS (2015)

Article Medicine, General & Internal

Advanced Dementia

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Clinical Neurology

Effects of cannabidiol in the treatment of patients with Parkinson's disease: An exploratory double-blind trial

Marcos Hortes N. Chagas et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2014)

Article Pharmacology & Pharmacy

Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?

Javier Fernandez-Ruiz et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2013)

Article Neurosciences

Cannabidiol enhances consolidation of explicit fear extinction in humans

Ravi K. Das et al.

PSYCHOPHARMACOLOGY (2013)

Article Substance Abuse

Around-the-clock oral THC effects on sleep in male chronic daily cannabis smokers

David A. Gorelick et al.

AMERICAN JOURNAL ON ADDICTIONS (2013)

Article Psychiatry

Risk of Mortality Among Individual Antipsychotics in Patients With Dementia

Helen C. Kales et al.

AMERICAN JOURNAL OF PSYCHIATRY (2012)

Article Clinical Neurology

Behavioral and Psychological Symptoms of Dementia

J. Cerejeira et al.

Frontiers in Neurology (2012)

Review Pharmacology & Pharmacy

Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects

Ethan B. Russo

BRITISH JOURNAL OF PHARMACOLOGY (2011)

Letter Pharmacology & Pharmacy

Randomized, Controlled Crossover Trial of Dronabinol, 2.5 mg, for Agitation in 2 Patients With Dementia

Sebastian Walther et al.

JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY (2011)

Article Clinical Neurology

Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report

Jose Alexandre S. Crippa et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2011)

Review Health Care Sciences & Services

Clinical features and multidisciplinary approaches to dementia care

Jacob H. G. Grand et al.

JOURNAL OF MULTIDISCIPLINARY HEALTHCARE (2011)

Article Anesthesiology

The Effects of Nabilone on Sleep in Fibromyalgia: Results of a Randomized Controlled Trial

Mark A. Ware et al.

ANESTHESIA AND ANALGESIA (2010)

Article Medicine, General & Internal

Smoked cannabis for chronic neuropathic pain: a randomized controlled trial

Mark A. Ware et al.

CANADIAN MEDICAL ASSOCIATION JOURNAL (2010)

Article Medicine, General & Internal

CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials

Kenneth F. Schulz et al.

BMJ-BRITISH MEDICAL JOURNAL (2010)

Article Clinical Neurology

Disruptive Behavior as a predictor in Alzheimer disease

Nikolaos Scarmeas et al.

ARCHIVES OF NEUROLOGY (2007)

Article Clinical Neurology

Quality of life in dementia: more than just cognition. An analysis of associations with quality of life in dementia

S Banerjee et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2006)

Review Medicine, Research & Experimental

The use of unequal randomisation ratios in clinical trials: A review

JC Dumville et al.

CONTEMPORARY CLINICAL TRIALS (2006)

Review Medicine, General & Internal

Risk of death with atypical antipsychotic drug treatment for dementia - Meta-analysis of randomized placebo-controlled trials

LS Schneider et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2005)

Article Clinical Neurology

Delusions and hallucinations are associated with worse outcome in Alzheimer disease

N Scarmeas et al.

ARCHIVES OF NEUROLOGY (2005)

Review Medicine, General & Internal

Pharmacological treatment of neuropsychiatric symptoms of dementia - A review of the evidence

KM Sink et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2005)

Review Pharmacology & Pharmacy

Pharmacokinetics and pharmacodynamics of cannabinoids

F Grotenhermen

CLINICAL PHARMACOKINETICS (2003)

Article Geriatrics & Gerontology

Measuring change in psychiatric symptoms using the Neuropsychiatric Inventory: Nursing Home version

GL Iverson et al.

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY (2002)

Article Geriatrics & Gerontology

The use of the neuropsychiatric inventory in nursing home residents -: Characterization and measurement

S Wood et al.

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY (2000)

Article Health Care Sciences & Services

Predicting elderly people's risk for nursing home placement, hospitalization, functional impairment, and mortality: A synthesis

EA Miller et al.

MEDICAL CARE RESEARCH AND REVIEW (2000)