4.6 Article

Factors associated with low prevalence of Fuchs' uveitis syndrome in Japan

Journal

FRONTIERS IN MEDICINE
Volume 9, Issue -, Pages -

Publisher

FRONTIERS MEDIA SA
DOI: 10.3389/fmed.2022.999804

Keywords

non-infectious uveitis; Fuchs' uveitis syndrome; Fuchs' heterochromic iridocyclitis; uveitis; cataract

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A retrospective review of medical records of 160 patients diagnosed with Fuchs' uveitis syndrome (FUS) in Japan revealed that the ocular findings were consistent with characteristic features of FUS, but the low prevalence of FUS in Japan may be due to being overlooked and misdiagnosed.
AimTo investigate the causes of low prevalence of Fuchs' uveitis syndrome (FUS) in Japan. MethodsMedical records of 160 patients diagnosed with FUS at 14 uveitis specialty facilities in Japan were reviewed retrospectively. ResultsIn 160 FUS patients, mean follow-up period before referral to our uveitis facilities was 31.6 +/- 50.9 months. The most common reason for referral was idiopathic uveitis (61.9%), followed by cataract (25.0%), high intraocular pressure (IOP) including glaucoma (16.3%), and FUS (14.4%). Unilateral involvement was 96.9%. The most frequent ocular finding of FUS was anterior inflammation (91.9%), followed by stellate-shaped keratic precipitates (88.1%), cataract/pseudophakia (88.1%), diffuse iris atrophy (84.4%), vitreous opacity (62.5%), heterochromia (53.1%) and high IOP including glaucoma (36.3%). As treatments of these ocular findings, cataract surgery was performed in 52.5%, glaucoma surgery in 10.6%, and vitrectomy in 13.8%. Mean logMAR VA was 0.28 +/- 0.59 at the initial visit, and decreased significantly to 0.04 +/- 0.32 at the last visit. Proportions of FUS patients with BCVA <0.1 and 0.1 to <0.5 decreased, while that of >= 0.5 increased at the last visit compared with the initial visit. ConclusionsOcular findings of FUS in Japanese FUS patients were consistent with the characteristic features. The low prevalence of FUS in Japan may be a result of being overlooked and misdiagnosed as mild idiopathic uveitis, cataract, and/or glaucoma.

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