4.6 Review

Critical evaluation of asthma biomarkers in clinical practice

Related references

Note: Only part of the references are listed.
Review Allergy

Real-world efficacy of treatment with benralizumab, dupilumab, mepolizumab and reslizumab for severe asthma: A systematic review and meta-analysis

David Charles et al.

Summary: This systematic review evaluates the real-world efficacy of recently and nearly licensed biological therapies for severe asthma. The results demonstrate that anti-IL5 biologicals may improve clinical outcomes in patients with severe asthma in a clinic environment with similar effect sizes to randomized controlled trials.

CLINICAL AND EXPERIMENTAL ALLERGY (2022)

Article Allergy

Real-life effectiveness of mepolizumab in severe asthma: a systematic literature review

Elliot Israel et al.

Summary: The study found that patients with severe asthma receiving mepolizumab treatment in real-world settings consistently demonstrate clinically relevant benefits, including reduced exacerbation rates, decreased oral corticosteroid doses, improved lung function, asthma control and health-related quality of life.

JOURNAL OF ASTHMA (2022)

Review Medicine, General & Internal

Biologic Therapies for Severe Asthma

Guy G. Brusselle et al.

Summary: Biologic therapies may be necessary to reduce the disease burden and risks for severe asthma patients. This review discusses the mechanisms, efficacy, and safety of biologics for severe asthma.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

Article Respiratory System

Early effectiveness of type-2 severe asthma treatment with dupilumab in a real-life setting; a FeNO-driven choice that leads to winning management

Giovanna Elisiana Carpagnano et al.

Summary: This study evaluated the early clinical improvement and changes in type 2 biomarkers in severe asthmatic patients treated with Dupilumab in a real-life setting. The results showed significant improvement in asthma symptoms, lung function, and FeNO after 3 months of treatment with Dupilumab.

MULTIDISCIPLINARY RESPIRATORY MEDICINE (2022)

Article Allergy

Blood eosinophil count and FeNO to predict benralizumab effectiveness in real-life severe asthma patients

Hirofumi Watanabe et al.

Summary: Benralizumab was effective in improving symptoms and reducing exacerbation frequency in patients with severe uncontrolled asthma. The majority of patients showed significant improvements in asthma control measures after 4 weeks of treatment, which continued through 24 weeks. Blood eosinophil count and FeNO levels at baseline can predict the effectiveness of benralizumab treatment.

JOURNAL OF ASTHMA (2022)

Article Respiratory System

Predictors of Low and High Exhaled Nitric Oxide Values in Asthma: A Real-World Study

Francesca Bertolini et al.

Summary: This study stratified asthma patients based on their exhaled nitric oxide (FENO) levels and identified specific clinical features and predictors for different FENO levels. The findings have important implications for tailoring treatment and improving outcomes in asthmatic patients.

RESPIRATION (2022)

Article

Defining type 2 asthma and patients eligible for dupilumab in Italy: a biomarker-based analysis

Giorgio Walter Canonica et al.

Clinical and Molecular Allergy (2021)

Article Allergy

The Prevalence of Subtypes of Type 2 Inflammation in an Unselected Population of Patients with Severe Asthma

Laurits Frossing et al.

Summary: This study examined the expression levels of T2 inflammatory markers in patients with severe asthma and their relationship with clinical characteristics and comorbidities. The majority of patients exhibited at least one T2 inflammatory trait, and the coexpression of T2 biomarkers showed high heterogeneity with distinct clinical characteristics.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2021)

Review Critical Care Medicine

Severe Adult Asthmas: Integrating Clinical Features, Biology, and Therapeutics to Improve Outcomes

Sally E. Wenzel

Summary: Evaluation and management of severe asthma remains a core focus in pulmonary practice. Advances in clinical phenotyping and molecular tools have greatly enhanced our understanding and treatment of severe asthma. Challenges still exist, but conceptual understanding of the disease has evolved significantly in a relatively short period of time.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2021)

Article Allergy

Overlap of allergic, eosinophilic and type 2 inflammatory subtypes in moderate-to-severe asthma

Meng Chen et al.

Summary: In this post hoc analysis in adults with moderate-to-severe asthma, allergic asthma was the most prevalent phenotype, followed by eosinophilic and type 2 asthma. Despite observed overlaps, a considerable proportion of patients had only a predominantly allergic subtype. Understanding the degree of overlap across phenotypes will help patient management and guide treatment options.

CLINICAL AND EXPERIMENTAL ALLERGY (2021)

Article Respiratory System

Distribution of inflammatory phenotypes among patients with asthma in Jilin Province, China: a cross-sectional study

Bingqing Shi et al.

Summary: The most common inflammatory cell phenotype among asthma patients in Jilin Province, China is PGA, followed by EA, MGA, and NA. The low prevalence of NA in Jilin Province may be attributed to excessive antibiotic use and irregular ICS treatment in the region.

BMC PULMONARY MEDICINE (2021)

Article Allergy

Severe asthma: One disease and multiple definitions

Diego Bagnasco et al.

Summary: The study found that different definitions of severe asthma can lead to heterogeneity in patient distribution, while the recent definition provided by the GINA document, similar to that indicated by ATS/ERS in 2014, can partially address this issue.

WORLD ALLERGY ORGANIZATION JOURNAL (2021)

Article Critical Care Medicine

The inflammatory profile of exacerbations in patients with severe refractory eosinophilic asthma receiving mepolizumab (the MEX study): a prospective observational study

P. Jane McDowell et al.

Summary: This study investigated the inflammatory phenotype and physiological characteristics of exacerbation events in patients with severe eosinophilic asthma treated with mepolizumab. The results showed that exacerbations on mepolizumab could be divided into non-eosinophilic events and eosinophilic events, which could be differentiated using FeNO as a marker. This challenges the routine use of oral corticosteroids for all asthma exacerbation events on mepolizumab, and emphasizes the importance of profiling the inflammatory phenotype for better management.

LANCET RESPIRATORY MEDICINE (2021)

Article Allergy

Cluster Analysis of Inflammatory Biomarker Expression in the International Severe Asthma Registry

Eve Denton et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2021)

Article Cardiac & Cardiovascular Systems

Mepolizumab effectiveness in patients with severe eosinophilic asthma and co-presence of bronchiectasis: A real-world retrospective pilot

Claudia Crimi et al.

Summary: The study demonstrated that mepolizumab effectively improves asthma symptom control, reduces annual exacerbations, and corticosteroid intake in both severe eosinophilic asthma patients with and without bronchiectasis.

RESPIRATORY MEDICINE (2021)

Editorial Material Medicine, Research & Experimental

Editorial: Review Articles, Systematic Reviews, Meta-Analysis, and the Updated Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 Guidelines

Dinah Parums

Summary: Subjective narrative review articles play an educational and informative role in medical and scientific journals. Systematic review and meta-analysis aim to provide an objective evaluation of all published data, supporting evidence-based medical practice. These studies require clear aims, detailed planning, and adherence to mandatory guidelines for design, conduct, and reporting.

MEDICAL SCIENCE MONITOR (2021)

Article Allergy

Variability of Type 2 inflammatory markers guiding biologic therapy of severe asthma: A 5-year retrospective study from a single tertiary hospital

Hongwen Li et al.

Summary: The study revealed individual distributions and variable patterns of T2 inflammatory markers in patients with severe asthma, offering guidance for the application of biologic therapies. Comprehensive multiple assessments of T2 inflammatory markers support personalized biologic therapy for patients with severe asthma based on their biomarker levels.

WORLD ALLERGY ORGANIZATION JOURNAL (2021)

Article Respiratory System

Mepolizumab improves sino-nasal symptoms and asthma control in severe eosinophilic asthma patients with chronic rhinosinusitis and nasal polyps: a 12-month real-life study

Aikaterini Detoraki et al.

Summary: In this study, mepolizumab treatment for 1 year in 44 severe eosinophilic asthma patients with CRSwNP showed significant improvements in sino-nasal symptoms, asthma symptoms, and a reduction in polyp growth.

THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE (2021)

Article Allergy

Short-Term Evaluation of Dupilumab Effects in Patients with Severe Asthma and Nasal Polyposis

Corrado Pelaia et al.

Summary: This study demonstrates that dupilumab shows significant improvement in both severe asthma and nasal polyposis in patients after 4 weeks of treatment. The results suggest that dupilumab can be a valuable add-on biological therapy for both allergic and nonallergic patients with rapid onset of action.

JOURNAL OF ASTHMA AND ALLERGY (2021)

Article Allergy

Severe asthma management in the era of biologics: insights of the Italian Registry on Severe Asthma (IRSA)

M. B. Bilo et al.

Summary: The Italian Registry on Severe Asthma (IRSA) has provided valuable insights into the clinical, inflammatory, and treatment characteristics of severe asthma patients, revealing a high proportion of uncontrolled asthma and multiple comorbidities among the enrolled subjects.

EUROPEAN ANNALS OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

Article Allergy

Dupilumab Efficacy in Patients with Uncontrolled, Moderate-to-Severe Allergic Asthma

Jonathan Corren et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2020)

Review Allergy

The Cellular Functions of Eosinophils: Collegium Internationale Allergologicum (CIA) Update 2020

Hans-Uwe Simon et al.

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2020)

Article Respiratory System

Mepolizumab effectiveness and identification of super-responders in severe asthma

Erin S. Harvey et al.

EUROPEAN RESPIRATORY JOURNAL (2020)

Article Allergy

Biologics for oral corticosteroid-dependent asthma

Insu Yilmaz

ALLERGY AND ASTHMA PROCEEDINGS (2020)

Article Allergy

Real-word experience with mepolizumab: Does it deliver what it has promised?

Florence Schleich et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2020)

Article Pharmacology & Pharmacy

Mepolizumab effectiveness on small airway obstruction, corticosteroid sparing and maintenance therapy step-down in real life

Bruno Sposato et al.

PULMONARY PHARMACOLOGY & THERAPEUTICS (2020)

Article Cardiac & Cardiovascular Systems

Efficacy of Benralizumab in severe asthma in real life and focus on nasal polyposis

Diego Bagnasco et al.

RESPIRATORY MEDICINE (2020)

Review Immunology

Mechanisms of non-type 2 asthma

Stephanie N. Hudey et al.

CURRENT OPINION IN IMMUNOLOGY (2020)

Article Respiratory System

Clinical characteristics of the BREATHE cohort - a real-life study on patients with asthma and COPD

Vibeke Backer et al.

EUROPEAN CLINICAL RESPIRATORY JOURNAL (2020)

Article Allergy

Refractory airway type 2 inflammation in a large subgroup of asthmatic patients treated with inhaled corticosteroids

Michael C. Peters et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

Review Allergy

Understanding Asthma Phenotypes, Endotypes, and Mechanisms of Disease

Merin E. Kuruvilla et al.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2019)

Review Allergy

Benralizumab: A New Approach for the Treatment of Severe Eosinophilic Asthma

Davila Gonzalez I et al.

JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY (2019)

Review Allergy

Phenotypes and endotypes of adult asthma: Moving toward precision medicine

Ravdeep Kaur et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

Article Critical Care Medicine

Remotely Monitored Therapy and Nitric Oxide Suppression Identifies Nonadherence in Severe Asthma

Liam G. Heaney et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2019)

Article Respiratory System

T2-high in severe asthma related to blood eosinophil, exhaled nitric oxide and serum periostin

Stelios Pavlidis et al.

EUROPEAN RESPIRATORY JOURNAL (2019)

Review Public, Environmental & Occupational Health

The Global Impact of Asthma in Adult Populations

Oladunni Enilari et al.

ANNALS OF GLOBAL HEALTH (2019)

Review Allergy

The eosinophil For better or worse, in sickness and in health

Bruce S. Bochner

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2018)

Article Medicine, General & Internal

Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma

Klaus F. Rabe et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Review Allergy

Role of airway epithelial barrier dysfunction in pathogenesis of asthma

Yasuhiro Gon et al.

ALLERGOLOGY INTERNATIONAL (2018)

Article Respiratory System

Baseline patient factors impact on the clinical efficacy of benralizumab for severe asthma

Eugene R. Bleecker et al.

EUROPEAN RESPIRATORY JOURNAL (2018)

Review Allergy

Asthma: personalized and precision medicine

Giorgio W. Canonica et al.

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY (2018)

Article Respiratory System

T-helper cell type 2 (Th2) and non-Th2 molecular phenotypes of asthma using sputum transcriptomics in U-BIOPRED

Chih-Hsi Scott Kuo et al.

EUROPEAN RESPIRATORY JOURNAL (2017)

Review Allergy

Omalizumab in children with uncontrolled allergic asthma: Review of clinical trial and real-world experience

Bradley E. Chipps et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

Article Allergy

U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics

Diane Lefaudeux et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

Article Allergy

A randomized multicenter study evaluating Xolair persistence of response after long-term therapy

Dennis Ledford et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

Article Medicine, General & Internal

Predictors of response to therapy with omalizumab in patients with severe allergic asthma - a real life study

Maria Kallieri et al.

POSTGRADUATE MEDICINE (2017)

Article Pharmacology & Pharmacy

Can the response to Omalizumab be influenced by treatment duration? A real-life study

Bruno Sposato et al.

PULMONARY PHARMACOLOGY & THERAPEUTICS (2017)

Review Immunology

Neutrophilic Inflammation in Asthma and Association with Disease Severity

Anuradha Ray et al.

TRENDS IN IMMUNOLOGY (2017)

Article Critical Care Medicine

Mepolizumab Attenuates Airway Eosinophil Numbers, but Not Their Functional Phenotype, in Asthma

Elizabeth A. Kelly et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2017)

Review Allergy

Phenotype-Driven Therapeutics in Severe Asthma

Maria Theresa D. Opina et al.

CURRENT ALLERGY AND ASTHMA REPORTS (2017)

Article Critical Care Medicine

A Transcriptome-driven Analysis of Epithelial Brushings and Bronchial Biopsies to Define Asthma Phenotypes in U-BIOPRED

Chih-Hsi Scott Kuo et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2017)

Review Allergy

The current and future role of biomarkers in type 2 cytokine-mediated asthma management

I. D. Pavord et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2017)

Review Medicine, General & Internal

Asthma phenotyping: a necessity for improved therapeutic precision and new targeted therapies

Kian Fan Chung

JOURNAL OF INTERNAL MEDICINE (2016)

Review Allergy

Characterization of asthma endotypes: implications for therapy

Jeffrey R. Stokes et al.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2016)

Article Allergy

A Phase 2a Study of Benralizumab for Patients with Eosinophilic Asthma in South Korea and Japan

Hae-Sim Park et al.

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2016)

Article Medicine, Research & Experimental

Lung-resident eosinophils represent a distinct regulatory eosinophil subset

Claire Mesnil et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Review Medicine, General & Internal

Exhaled nitric oxide levels to guide treatment for adults with asthma

Helen L. Petsky et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2016)

Article Respiratory System

Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort

Dominick E. Shaw et al.

EUROPEAN RESPIRATORY JOURNAL (2015)

Article Respiratory System

Biomarkers to identify sputum eosinophilia in different adult asthma phenotypes

Guus A. Westerhof et al.

EUROPEAN RESPIRATORY JOURNAL (2015)

Article Pharmacology & Pharmacy

Characterization of the relationship between dose and blood eosinophil response following subcutaneous administration of mepolizumab

Isabelle J. Pouliquen et al.

INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS (2015)

Article Respiratory System

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

Kian Fan Chung et al.

EUROPEAN RESPIRATORY JOURNAL (2014)

Article Allergy

Lung function decline and variable airway inflammatory pattern: Longitudinal analysis of severe asthma

Christopher Newby et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2014)

Article Medicine, General & Internal

Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma

Hector G. Ortega et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Allergy

Neutrophilic asthma is characterised by increased rhinosinusitis with sleep disturbance and GERD

Jodie L Simpson

ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY (2013)

Article Dentistry, Oral Surgery & Medicine

Resorption: part 2. Diagnosis and management

J. Darcey et al.

BRITISH DENTAL JOURNAL (2013)

Editorial Material Allergy

What is an eosinophilic phenotype of asthma?

Parameswaran Nair

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2013)

Article Allergy

Biomarker surrogates do not accurately predict sputum eosinophil and neutrophil percentages in asthmatic subjects

Annette T. Hastie et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2013)

Article Allergy

Effects of benralizumab on airway eosinophils in asthmatic patients with sputum eosinophilia

Michel Laviolette et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2013)

Article Medicine, General & Internal

Dupilumab in Persistent Asthma with Elevated Eosinophil Levels

Sally Wenzel et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Cardiac & Cardiovascular Systems

Discordance between asthma control clinical, physiological and inflammatory parameters in mild asthma

Marie-Eve Boulay et al.

RESPIRATORY MEDICINE (2013)

Article Critical Care Medicine

A Large Subgroup of Mild-to-Moderate Asthma Is Persistently Noneosinophilic

Kelly Wong McGrath et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2012)

Review Biochemistry & Molecular Biology

Asthma phenotypes: the evolution from clinical to molecular approaches

Sally E. Wenzel

NATURE MEDICINE (2012)

Article Critical Care Medicine

Eosinophils Are Dispensable for Allergic Remodeling and Immunity in a Model of House Dust Mite-induced Airway Disease

Ramzi Fattouh et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2011)

Article Critical Care Medicine

Reslizumab for Poorly Controlled, Eosinophilic Asthma A Randomized, Placebo-controlled Study

Mario Castro et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2011)

Article Critical Care Medicine

An Official ATS Clinical Practice Guideline: Interpretation of Exhaled Nitric Oxide Levels (FENO) for Clinical Applications

Raed A. Dweik et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2011)

Article Medicine, General & Internal

Omalizumab in Severe Allergic Asthma Inadequately Controlled With Standard Therapy A Randomized Trial

Nicola A. Hanania et al.

ANNALS OF INTERNAL MEDICINE (2011)

Article Critical Care Medicine

Identification of Asthma Phenotypes Using Cluster Analysis in the Severe Asthma Research Program

Wendy C. Moore et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2010)

Article Allergy

Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes

Annette T. Hastie et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2010)

Article Respiratory System

Assessment and Reproducibility of Non-Eosinophilic Asthma Using Induced Sputum

Jodie L. Simpson et al.

RESPIRATION (2010)

Article Respiratory System

Effects of steroid therapy on inflammatory cell subtypes in asthma

Douglas C. Cowan et al.

THORAX (2010)

Article Critical Care Medicine

T-helper Type 2-driven Inflammation Defines Major Subphenotypes of Asthma

Prescott G. Woodruff et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2009)

Article Respiratory System

Exhaled nitric oxide as a marker of asthma control in smoking patients

A. Michils et al.

EUROPEAN RESPIRATORY JOURNAL (2009)

Article Medicine, General & Internal

Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma

Pranabashis Haldar et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

Article Critical Care Medicine

Cluster analysis and clinical asthma phenotypes

Pranab Haldar et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2008)

Article Respiratory System

Exhaled nitric oxide and asthma control: a longitudinal study in unselected patients

A. Michils et al.

EUROPEAN RESPIRATORY JOURNAL (2008)

Article Critical Care Medicine

A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma

Patrick Flood-Page et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2007)

Article Critical Care Medicine

The use of exhaled nitric oxide to guide asthma management - A randomized controlled trial

Dominick E. Shaw et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2007)

Review Pharmacology & Pharmacy

Immunoglobulin E: Role in asthma and allergic disease: Lessons from the clinic

Charles E. Owen

PHARMACOLOGY & THERAPEUTICS (2007)

Article Cardiac & Cardiovascular Systems

Exhaled nitric oxide as a diagnostic test for asthma in rhinitic patients with asthmatic symptoms

Enrico Heffler et al.

RESPIRATORY MEDICINE (2006)

Article Respiratory System

Early rise in exhaled nitric oxide and mast cell activation in repeated low-dose allergen challenge

E. Ihre et al.

EUROPEAN RESPIRATORY JOURNAL (2006)

Article Respiratory System

Determining asthma treatment by monitoring sputum cell counts:: effect on exacerbations

L Jayaram et al.

EUROPEAN RESPIRATORY JOURNAL (2006)

Article Cardiac & Cardiovascular Systems

Clinical features and airway inflammation in mild asthma versus asymptomatic airway hyperresponsiveness

LP Boulet et al.

RESPIRATORY MEDICINE (2006)

Article Medicine, General & Internal

Use of exhaled nitric oxide measurements to guide treatment in chronic asthma

AD Smith et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)

Article Critical Care Medicine

ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005

American Thoracic Society et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2005)

Article Allergy

Sputum eosinophil counts predict asthma control after discontinuation of inhaled corticosteroids

A Deykin et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2005)

Review Allergy

Determinants of asthma and its clinical course

BE Chipps

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2004)

Article Critical Care Medicine

Effects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthma

R Djukanovic et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2004)

Article Respiratory System

Reproducibility of exhaled nitric oxide measurements in healthy and asthmatic adults and children

SA Kharitonov et al.

EUROPEAN RESPIRATORY JOURNAL (2003)

Article Medicine, General & Internal

Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial

RH Green et al.

LANCET (2002)

Article Respiratory System

Sputum induction

PL Paggiaro et al.

EUROPEAN RESPIRATORY JOURNAL (2002)

Article Respiratory System

Exhaled NO and assessment of anti-inflammatory effects of inhaled steroid: dose-response relationship

SL Jones et al.

EUROPEAN RESPIRATORY JOURNAL (2002)

Review Respiratory System

Non-eosinophilic asthma: importance and possible mechanisms

J Douwes et al.

THORAX (2002)

Article Critical Care Medicine

Airway inflammation is present during clinical remission of atopic asthma

LM Van den Toorn et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2001)

Article Critical Care Medicine

The role of immunoglobulin E in allergy and asthma

TAE Platts-Mills

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2001)

Article Critical Care Medicine

The predictive value of exhaled nitric oxide measurements in assessing changes in asthma control

SL Jones et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2001)

Article Critical Care Medicine

Induced sputum cell counts in healthy adults

J Belda et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2000)

Article Critical Care Medicine

Induced sputum cellularity - Reference values and distribution in normal volunteers

A Spanevello et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2000)