Do we miss rare adverse events induced by COVID-19 vaccination?

Letter Rheumatology

Case of adult large vessel vasculitis after SARS-CoV-2 infection

Ryohei Oda et al.

ANNALS OF THE RHEUMATIC DISEASES (2023)

Review Infectious Diseases

Comparing COVID-19 vaccines for their characteristics, efficacy and effectiveness against SARS-CoV-2 and variants of concern: a narrative review

Thibault Fiolet et al.

Summary: Overall, COVID-19 vaccines have high efficacy against the original strain and variants of concern, with rare serious adverse events. However, prices vary significantly for different vaccines.

CLINICAL MICROBIOLOGY AND INFECTION (2022)

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Article Dermatology

Flare-up of generalized pustular psoriasis combined with systemic capillary leak syndrome after coronavirus disease 2019 mRNA vaccination

Kazuki Yatsuzuka et al.

Summary: This case report describes a 65-year-old male who experienced a flare-up of GPP accompanied by SCLS following COVID-19 mRNA vaccination. The patient had skin eruption at the injection site and systemic capillary leak syndrome. Biopsies showed typical GPP findings with mixed-cell infiltration, eosinophils, and microthrombi in the small dermal vessels.

JOURNAL OF DERMATOLOGY (2022)

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Letter Dermatology

Recurrence of cutaneous T-cell lymphoma post viral vector COVID-19 vaccination

E. Panou et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2022)

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Article Hematology

Vaccine-induced immune thrombotic thrombocytopenia (VITT): Update on diagnosis and management considering different resources

Andreas Greinacher et al.

Summary: VITT is a rare but severe immunological reaction to non-replicable adenoviral vector-based COVID-19 vaccines, causing extreme activation of platelets and the coagulation system, increasing the risk of death. The World Health Organization provided guidelines for the diagnosis and management of VITT, and authors summarized new clinically relevant information with recommendations for low resource environments.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2022)

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Article Multidisciplinary Sciences

Germinal centre-driven maturation of B cell response to mRNA vaccination

Wooseob Kim et al.

Summary: SARS-CoV-2 mRNA vaccination induces a persistent germinal center reaction in humans, resulting in affinity-matured long-term antibody responses that potently neutralize the virus.

NATURE (2022)

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Article Dermatology

Cutaneous Small-vessel Vasculitis after ChAdOx1 COVID-19 Vaccination: A Report of Five Cases

Ji An Uh et al.

Summary: This study reports five cases of cutaneous small-vessel vasculitis (CSVV) in women after the ChAdOx1 COVID-19 vaccination. Symptoms commonly appeared within 2 days after vaccination, with localized lesion in the lower limbs and occasional spread to the upper limbs. All patients responded well to treatment. Further research is needed to understand the underlying cause and pathogenesis.

INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS (2022)

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Article Immunology

Eosinophilic Granulomatosis with Polyangiitis Relapse after COVID-19 Vaccination: A Case Report

Giulia Costanzo et al.

Summary: This is a case report of a 71-year-old Caucasian woman with Eosinophilic Granulomatosis with Polyangiitis (EGPA). She had been treated with Mepolizumab since 2019 and had a good clinical response. In December 2020, she had a mild COVID-19 and tested negative for SARS-CoV-2 infection in late January 2021. After receiving the first dose of mRNA BNT162b2 vaccine in April 2021, she experienced a relapse of EGPA with symptoms of myalgia, dyspnea and limb numbness.

VACCINES (2022)

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Review Medicine, General & Internal

The pathogenesis of COVID-19-induced IgA nephropathy and IgA vasculitis: A systematic review

Hareem Farooq et al.

Summary: This review investigates the association of IgA nephropathy (IgAN) and IgA vasculitis (IgAV) with COVID-19, finding a higher incidence of these two diseases in COVID-19 patients, with a predominance of male patients. The most common clinical features are rash, purpura, and gastrointestinal symptoms. Currently, there is a lack of scientific evidence on the pathogenesis of this association, which requires further study.

JOURNAL OF TAIBAH UNIVERSITY MEDICAL SCIENCES (2022)

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Letter Endocrinology & Metabolism

Can COVID-19 immunisation cause subacute thyroiditis?

Gowri M. Ratnayake et al.

CLINICAL ENDOCRINOLOGY (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

[18F]FDG uptake of axillary lymph nodes after COVID-19 vaccination in oncological PET/CT: frequency, intensity, and potential clinical impact

Stephan Skawran et al.

Summary: FDG-avid axillary lymph nodes are common after COVID-19 vaccination, with a higher frequency observed in patients who received the Moderna vaccine compared to the Pfizer-BioNTech vaccine. Clinical management was affected in some cases due to the presence of FDG-avid lymph nodes.

EUROPEAN RADIOLOGY (2022)

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Editorial Material Ophthalmology

Acute macular neuroretinopathy following COVID-19 vaccination

Anders Djupesland Bohler et al.

EYE (2022)

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Article Clinical Neurology

Acute transverse myelitis following SARS-CoV-2 vaccination: a case report and review of literature

Erum Khan et al.

Summary: This study reported a unique case of transverse myelitis following COVID-19 vaccination and reviewed relevant literature. The patient responded well to treatment, but further research is needed to identify the potential correlation between COVID-19 vaccination and transverse myelitis.

JOURNAL OF NEUROLOGY (2022)

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Article Immunology

Diffuse cutaneous systemic sclerosis following SARS-Co V-2 vaccination

Alice Cole et al.

Summary: This article reports a case of diffuse cutaneous systemic sclerosis in a 70-year-old male following COVID-19 vaccination. The authors suspect a possible adverse reaction to the vaccine resulting in an atypical presentation of systemic sclerosis. The article discusses the potential mechanisms of autoimmune reactions triggered by vaccination in rheumatology.

JOURNAL OF AUTOIMMUNITY (2022)

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Review Virology

Vaccine-induced immune thrombotic thrombocytopenia after vaccination against Covid-19: A clinical dilemma for clinicians and patients

Zeinab Mohseni Afshar et al.

Summary: The Covid-19 pandemic has had devastating effects on global public health, but the deployment of vaccines has helped control the virus. While common side effects following vaccination are usually self-restricted, there have been rare cases of vaccine-induced thrombosis. This review summarizes thrombotic events after Covid-19 vaccination and provides a management plan, emphasizing the importance of vaccination to overcome the pandemic.

REVIEWS IN MEDICAL VIROLOGY (2022)

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Review Rheumatology

Systemic Capillary Leak Syndrome triggered by SARS-CoV2 infection: Case Report and Systematic Review

A. Beber et al.

Summary: The study reveals that SARS-CoV-2 infection may trigger SCLS disease, leading to a high mortality rate of 50% among patients who require intensive care unit treatment.

SCANDINAVIAN JOURNAL OF RHEUMATOLOGY (2022)

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Article Biotechnology & Applied Microbiology

Systemic sclerosis and vaccinations: a three-year register-based cohort study about vaccination rate and uptake from Liguria referral center, northwest Italy

Giuseppe Murdaca et al.

Summary: Vaccination is crucial in preventing and caring for patients with diffused Systemic Sclerosis (dSSc), reducing morbidity and mortality rates. This study aims to analyze the vaccination coverage of S. pneumoniae and seasonal influenza in a cohort of 91 SSc patients and investigate the demographic and clinical factors associated with vaccine acceptance. The study found that the vaccination rates were higher than the general population, especially among subjects undergoing immunosuppressive therapies and elderly subjects.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2022)

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Article Medicine, General & Internal

The Safety of Anti-SARS-CoV-2 Vaccines: Vigilance Is Still Required

Michel Goldman

Summary: The paper suggests that attention should be given to clinical observations of anti-SARS-CoV-2 vaccines potentially causing harmful effects in certain immunological diseases. The example of atypical thrombocytopenic thromboses caused by adenoviral-vector-based vaccines is used to argue that post-marketing pharmacovigilance programs may not be sufficient in identifying rare vaccine-related disorders. Additionally, the safety of mRNA vaccines is proposed to be further assessed through appropriately designed epidemiological and mechanistic studies focusing on lymphoproliferative and autoimmune diseases involving T follicular helper cells.

JOURNAL OF CLINICAL MEDICINE (2022)

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Review Medicine, General & Internal

Post-COVID-19 vaccine medium-vessel vasculitis and acute anterior uveitis, causation vs temporal relation; case report and literature review

Abdul-Wahab Al-Allaf et al.

Summary: This article presents a case of a middle-aged man who developed vasculitis involving the celiac trunk and its branches, and acute anterior uveitis after receiving the Pfizer BioNTech COVID-19 vaccine. It highlights the need for further research to establish an association between the COVID-19 vaccine and these immunologic phenomena.

ANNALS OF MEDICINE AND SURGERY (2022)

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Article Medicine, General & Internal

Systemic capillary leak syndrome (SCLS) after receiving BNT162b2 mRNA COVID-19 (Pfizer-BioNTech) vaccine

Masatoshi Inoue et al.

Summary: Systemic capillary leak syndrome (SCLS), also known as Clarkson's disease, is a rare disorder characterized by the classic triad of hypotension, haemoconcentration and hypoalbuminaemia. It may sometimes occur as a side effect of certain vaccines, and early recognition and treatment are crucial for improving survival rates.

BMJ CASE REPORTS (2022)

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Article Cardiac & Cardiovascular Systems

A Case of Systemic Capillary Leak Syndrome With Severe Cardiac Dysfunction After mRNA Vaccination for COVID-19

Takashi Araki et al.

Summary: This case report describes a woman who developed severe cardiac dysfunction after receiving the COVID-19 mRNA vaccine, diagnosed with severe SCLS induced by vaccination. It suggests that SCLS can occur after vaccination and may be associated with cardiac dysfunction. SCLS should be considered in patients with cardiogenic shock, hemoconcentration, and hypoalbuminemia after vaccination.

CJC OPEN (2022)

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Review Allergy

Cutaneous Vasculitis: Review on Diagnosis and Clinicopathologic Correlations

Laure Frumholtz et al.

Summary: Cutaneous vasculitis is an inflammatory disease affecting the dermal blood vessel walls, which can reflect different forms of systemic vasculitis with diverse clinical manifestations depending on the location and size of the vessels involved.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2021)

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Letter Virology

COVID-19 presenting with immune thrombocytopenia: A case report and review of the literature

Ahmet Murt et al.

JOURNAL OF MEDICAL VIROLOGY (2021)

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Letter Virology

Pulmonary capillary leak syndrome following COVID-19 virus infection

Mabrouk Bahloul et al.

JOURNAL OF MEDICAL VIROLOGY (2021)

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Review Ophthalmology

Paracentral acute middle maculopathy and the organization of the retinal capillary plexuses *

Jackson Scharf et al.

Summary: The retinal capillary vasculature plays a key role in supplying blood to the metabolically active inner and middle retina. PAMM is a result of the deep vascular complex blood flow failure, potentially leading to permanent visual impairment.

PROGRESS IN RETINAL AND EYE RESEARCH (2021)

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Review Pediatrics

Myocarditis and Pericarditis Following mRNA COVID-19 Vaccination: What Do We Know So Far?

Bibhuti B. Das et al.

Summary: This cross-sectional study of 29 cases of acute myopericarditis following COVID-19 mRNA vaccination found that chest pain was the most common symptom, occurring within 1-5 days. All patients had elevated troponin levels, with most recovering within 1-3 weeks. Treatment mainly involved non-steroidal anti-inflammatory drugs, with some patients receiving intravenous immune globulin and corticosteroids.

CHILDREN-BASEL (2021)

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Letter Rheumatology

Reactivation of IgA vasculitis after COVID-19 vaccination

Michel Obeid et al.

LANCET RHEUMATOLOGY (2021)

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Article Hematology

Characterization of New Monoclonal PF4-Specific Antibodies as Useful Tools for Studies on Typical and Autoimmune Heparin-Induced Thrombocytopenia

Caroline Vayne et al.

Summary: 1C12, 1E12, and 2E1 demonstrate higher affinity for PF4/H complexes compared to 5B9 and KKO, similar to human group-3 Abs. These antibodies form large complexes with PF4 and activate platelets without heparin, providing new insights into the pathophysiology of autoimmune HIT.

THROMBOSIS AND HAEMOSTASIS (2021)

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Article Medicine, General & Internal

Case of Guillain-Barre syndrome following COVID-19 vaccine

Tanveer Hasan et al.

Summary: This case report presents a instance of Guillain-Barre syndrome occurring after receiving the Oxford/AstraZeneca COVID-19 vaccine. While a direct link could not be established, it emphasizes the need to consider this issue when evaluating cases of GBS.

BMJ CASE REPORTS (2021)

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Article Medicine, General & Internal

Guillain-Barre syndrome after COVID-19 vaccination

Norma McKean et al.

Summary: The correlation between COVID-19 infection/vaccination and GBS remains unclear, requiring ongoing assessment of risks. The specific presentation of bifacial weakness as a symptom of GBS may be related to COVID-19 vaccination.

BMJ CASE REPORTS (2021)

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Article Medicine, General & Internal

Sequential contralateral facial nerve palsies following COVID-19 vaccination first and second doses

Abigail Burrows et al.

Summary: A 61-year-old man presented with unilateral facial nerve palsy shortly after each dose of Pfizer-BioNTech COVID-19 vaccine. This is the first reported case of Bell's palsy occurring after each dose of any UK-approved COVID-19 vaccine. While single episodes of unilateral facial nerve palsies have been reported, there is no evidence supporting onset after each dose.

BMJ CASE REPORTS (2021)

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Article Cardiac & Cardiovascular Systems

Pericarditis after administration of the BNT162b2 mRNA COVID-19 vaccine

Almudena Ramírez-García et al.

Revista española de cardiología (English ed.) (2021)

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Article

Acute-onset central serous retinopathy after immunization with COVID-19 mRNA vaccine

Nicholas Fowler et al.

American Journal of Ophthalmology Case Reports (2021)

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Article Urology & Nephrology

Minimal Change Disease With Severe Acute Kidney Injury Following the Oxford-AstraZeneca COVID-19 Vaccine: A Case Report

Simon Leclerc et al.

Summary: This case report describes a patient who developed minimal change disease (MCD) and severe acute kidney injury (AKI) following the Oxford-AstraZeneca COVID-19 vaccine. Treatment with glucocorticoids improved kidney function and proteinuria. Further research is needed to determine the association between MCD and COVID-19 vaccination.

AMERICAN JOURNAL OF KIDNEY DISEASES (2021)

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Article Dermatology

Clinicopathologic correlations of COVID-19-related cutaneous manifestations with special emphasis on histopathologic patterns

Franco Rongioletti et al.

Summary: COVID-19 affects the skin directly, but there is limited understanding of the histopathologic characteristics of skin manifestations and confusion in the nosology of clinically similar conditions. Further research and advancements in research methods may lead to significant breakthroughs.

CLINICS IN DERMATOLOGY (2021)

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Article Medicine, General & Internal

Hypoalbuminemia in COVID-19: assessing the hypothesis for underlying pulmonary capillary leakage

M. A. Wu et al.

Summary: The study found that hypoalbuminaemia could serve as a marker of severity in patients with COVID-19, indicating epithelial-endothelial damage. Additionally, there are indications that pulmonary capillary leak syndrome plays a crucial role in the pathogenesis of COVID-19.

JOURNAL OF INTERNAL MEDICINE (2021)

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Article Medicine, General & Internal

COVID-19: IgG seroconversion under intensive glucocorticoid treatment in a high-risk patient with minimal change disease

Michael Eder et al.

Summary: The patient had multiple risk factors for severe COVID-19 and received intensive glucocorticoid treatment, yet only developed mild disease with IgG SARS-CoV-2 seroconversion.

WIENER KLINISCHE WOCHENSCHRIFT (2021)

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Article Infectious Diseases

Facial nerve palsy following the administration of COVID-19 mRNA vaccines: analysis of a self-reporting database

Kenichiro Sato et al.

Summary: A study investigated cases of facial nerve palsy following COVID-19 mRNA vaccines using the VAERS database and found the adverse event to be significantly higher reported compared to influenza vaccines, but possibly lower or equivalent in incidence.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2021)

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Article Public, Environmental & Occupational Health

Allergic Reactions Including Anaphylaxis After Receipt of the First Dose of Moderna COVID-19 Vaccine — United States, December 21, 2020–January 10, 2021

et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2021)

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Editorial Material Hematology

Thrombocytopenia following Pfizer and Moderna SARS-CoV-2 vaccination

Eun-Ju Lee et al.

AMERICAN JOURNAL OF HEMATOLOGY (2021)

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Editorial Material Radiology, Nuclear Medicine & Medical Imaging

The Canadian Society of Breast Imaging Recommendations for the Management of Axillary Adenopathy in Patients with Recent COVID-19 Vaccination - Update

Jean M. Seely et al.

CANADIAN ASSOCIATION OF RADIOLOGISTS JOURNAL-JOURNAL DE L ASSOCIATION CANADIENNE DES RADIOLOGISTES (2021)

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Letter Urology & Nephrology

Acute kidney injury with gross hematuria and IgA nephropathy after COVID-19 vaccination

Richard Plasse et al.

KIDNEY INTERNATIONAL (2021)

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Review Clinical Neurology

Cerebral venous sinus thrombosis associated with COVID-19: a case series and literature review

Vahid Reza Ostovan et al.

Summary: This study reported six cases of confirmed CVST and SARS-CoV-2 infection, with four patients presenting no respiratory symptoms. Patients with SARS-COV-2 associated CVST were older, with lower female/male ratio and higher mortality rate compared to CVST not associated with COVID-19. Despite receiving treatment, four patients died.

JOURNAL OF NEUROLOGY (2021)

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Editorial Material Public, Environmental & Occupational Health

'Blue toes' following vaccination with the Pfizer BNT162b2 mRNA COVID-19 vaccine

Benjamin Davido et al.

JOURNAL OF TRAVEL MEDICINE (2021)

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Editorial Material Radiology, Nuclear Medicine & Medical Imaging

Imaging of COVID-19 Vaccination at FDG PET/CT

Michal Eifer et al.

RADIOLOGY (2021)

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Article Biotechnology & Applied Microbiology

Hypermetabolic abdominal and cervical lymph nodes mimicking Hodgkin lymphoma relapse on FDG PET/CT after adenovirus-vectored COVID-19 vaccine

Elena Landete et al.

Summary: This case report highlights a 33-year-old woman with a history of Classic Hodgkin Lymphoma who developed hypermetabolic lymph nodes after receiving the adenovirus-vectored COVID-19 vaccine, which were initially concerning for disease relapse but later resolved, emphasizing the importance of considering false positives in such scenarios.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2021)

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Article Urology & Nephrology

Minimal Change Disease Following the Pfizer-BioNTech COVID-19 Vaccine

Larissa Lebedev et al.

Summary: A 50-year-old man developed minimal change disease (MCD) with nephrotic syndrome and acute kidney injury (AKI) shortly after receiving his first dose of the Pfizer-BioNTech COVID-19 vaccine. Treatment with prednisone was initiated and kidney function gradually improved, eventually returning to normal. While the association between the vaccine and MCD is temporal and by exclusion, further reports are needed to evaluate the true incidence of this potential vaccine side effect.

AMERICAN JOURNAL OF KIDNEY DISEASES (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Frequency and Characteristics of Nodal and Deltoid FDG and 11C-Choline Uptake on PET Performed After COVID-19 Vaccination

Dane G. Schroeder et al.

Summary: This study aimed to evaluate the frequency and characteristics of abnormal FDG and C-11-choline uptake on PET performed after COVID-19 vaccination. The results showed occasional increased axillary lymph node or ipsilateral deltoid uptake on FDG or C-11-choline PET after vaccination with the Pfizer-BioNTech or Moderna vaccine. Physicians interpreting PET findings after COVID-19 vaccination should be aware of these characteristics to guide appropriate follow-up management and avoid unnecessary biopsies.

AMERICAN JOURNAL OF ROENTGENOLOGY (2021)

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Article Immunology

Cerebral venous sinus thrombosis and thrombocytopenia after COVID-19 vaccination-A report of two UK cases

Puja R. Mehta et al.

Summary: Recent reports have highlighted rare cases of CVST and thrombocytopenia following Vaxzevria vaccination. An immunological mechanism similar to HIT, but without prior heparin exposure, is suspected. Management of such cases involves PF4 antibody testing and treatment similar to HIT.

BRAIN BEHAVIOR AND IMMUNITY (2021)

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Editorial Material Dermatology

Chilblain lesions after COVID-19 mRNA vaccine

A. Pileri et al.

BRITISH JOURNAL OF DERMATOLOGY (2021)

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Article Medicine, General & Internal

Thrombotic thrombocytopenia due to SARS-CoV-2 vaccination

Keith R. McCrae

CLEVELAND CLINIC JOURNAL OF MEDICINE (2021)

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Review Hematology

Diagnosis and Management of Vaccine-Related Thrombosis following AstraZeneca COVID-19 Vaccination: Guidance Statement from the GTH

Johannes Oldenburg et al.

HAMOSTASEOLOGIE (2021)

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Letter Dermatology

Acral chilblain-like lesions following inactivated SARS-CoV-2 vaccination

Selami Aykut Temiz et al.

INTERNATIONAL JOURNAL OF DERMATOLOGY (2021)

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Letter Dermatology

Leukocytoclastic vasculitis flare following the COVID-19 vaccine

Stephanie R. Cohen et al.

INTERNATIONAL JOURNAL OF DERMATOLOGY (2021)

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Article Immunology

Henoch-Schonlein Purpura Following the First Dose of COVID-19 Viral Vector Vaccine: A Case Report

Maria Maddalena Sirufo et al.

Summary: This case report describes a female who developed HSP after receiving the COVID-19 vaccine ChAdOx1 nCoV-19 AZD1222, which is the first report of its kind. No similar cases were reported in the ChAdOx1 nCoV-19 AZD1222 trial with 23,848 participants.

VACCINES (2021)

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Article Medicine, General & Internal

Rapid Progression of Angioimmunoblastic T Cell Lymphoma Following BNT162b2 mRNA Vaccine Booster Shot: A Case Report

Serge Goldman et al.

Summary: Nucleoside-modified mRNA vaccines have a strong impact on T follicular helper cells, which may influence the development of neoplasms. This report discusses the unexpected rapid progression of lymphomatous lesions in a man diagnosed with AITL after receiving a BNT162b2 mRNA vaccine booster.

FRONTIERS IN MEDICINE (2021)

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Letter Dermatology

BNT162b2 mRNA COVID-19 vaccine-induced chilblain-like lesions reinforces the hypothesis of their relationship with SARS-CoV-2

V. Piccolo et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2021)

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Article Hematology

Thrombocytopenia with acute ischemic stroke and bleeding in a patient newly vaccinated with an adenoviral vector-based COVID-19 vaccine

Rolf Ankerlund Blauenfeldt et al.

Summary: This study reported the first Danish case of presumed inflammatory and thrombotic response following vaccination with the AZD1222 COVID-19 vaccine. The patient, a 60-year-old woman, experienced abdominal pain 7 days after vaccination, along with adrenal hemorrhages, ischemic stroke, and ultimately death. Blood tests revealed significant drops in platelet counts and increased D-dimer levels, suggesting a novel immune-mediated response to the vaccine.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2021)

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Article Hematology

A case report of acquired hemophilia following COVID-19 vaccine

Mansoor Radwi et al.

Summary: The report describes a 69-year-old man who developed Acquired Hemophilia A after receiving the COVID-19 vaccine, a rare occurrence. Other studies have also linked AHA to seasonal flu vaccines, H1N1 vaccines, and COVID-19 infection.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2021)

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Letter Urology & Nephrology

A case of gross hematuria and IgA nephropathy flare-up following SARS-CoV-2 vaccination

Shab E. Gul Rahim et al.

KIDNEY INTERNATIONAL (2021)

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Letter Oncology

Recurrence of primary cutaneous CD30-positive lymphoproliferative disorder following COVID-19 vaccination

Caitlin M. Brumfiel et al.

LEUKEMIA & LYMPHOMA (2021)

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Article Medicine, General & Internal

Pathologic Antibodies to Platelet Factor 4 after ChAdOx1 nCoV-19 Vaccination

Marie Scully et al.

Summary: 23 cases of thrombotic thrombocytopenia were reported after receiving the AstraZeneca vaccine, incited by antibodies to platelet factor 4 and unrelated to heparin therapy. Avoidance of platelet transfusion and consideration of nonheparin anticoagulant and intravenous immune globulin are recommended for treatment.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Editorial Material Medicine, General & Internal

SARS-CoV-2 Vaccine-Induced Immune Thrombotic Thrombocytopenia

Douglas B. Cines et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Medicine, General & Internal

Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination

Andreas Greinacher et al.

Summary: After vaccination with ChAdOx1 nCov-19, rare immune thrombotic thrombocytopenia can occur due to platelet-activating antibodies against PF4, resulting in various thrombotic events. Most patients in this case series were women, with fatal outcomes such as cerebral venous thrombosis and intracranial hemorrhage. Additional studies are needed to further investigate and understand this phenomenon.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Review Endocrinology & Metabolism

New aspects in the pathogenesis and management of subacute thyroiditis

Magdalena Stasiak et al.

Summary: Subacute thyroiditis (SAT) is a thyroid inflammatory disease, and recent years have seen significant new data on its epidemiology, pathogenesis, and management. Certain human leukocyte antigen (HLA) alleles have been shown to increase the risk of SAT, affecting its clinical course and recurrence risk.

REVIEWS IN ENDOCRINE & METABOLIC DISORDERS (2021)

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Letter Pharmacology & Pharmacy

Type I interferons as the potential mechanism linking mRNA COVID-19 vaccines to Bell's palsy

Thomas Soeiro et al.

THERAPIE (2021)

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Article Endocrinology & Metabolism

Two Cases of Graves' Disease Following SARS-CoV-2 Vaccination: An Autoimmune/Inflammatory Syndrome Induced by Adjuvants

Olga Vera-Lastra et al.

Summary: Two female health care workers developed clinical manifestations of thyroid hyperactivity, increased thyroid hormone levels, suppressed thyroid-stimulating hormone, and elevated antithyroid antibodies three days after receiving a SARS-CoV-2 vaccine. This indicates a potential link between SARS-CoV-2 vaccination and the onset of autoimmune thyroid diseases like Graves' disease.

THYROID (2021)

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Article Immunology

Thrombocytopenia including immune thrombocytopenia after receipt of mRNA COVID-19 vaccines reported to the Vaccine Adverse Event Reporting System (VAERS)

Kerry J. Welsh et al.

Summary: This study analyzed VAERS reports of thrombocytopenia after vaccination with Pfizer-BioNTech COVID-19 Vaccine or Moderna COVID-19 Vaccine. The results showed a reporting rate of 0.80 per million doses for both vaccines, and the observed number of all thrombocytopenia cases following administration of mRNA COVID-19 vaccines is not greater than the number of ITP cases expected. Conclusion: The number of thrombocytopenia cases reported to VAERS does not suggest a safety concern attributable to mRNA COVID-19 vaccines at this time.

VACCINE (2021)

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Article Medicine, General & Internal

Subacute thyroiditis following COVID-19 vaccination

Pardis Soltanpoor et al.

Summary: Physicians should be vigilant about the potential development of subacute thyroiditis (SAT) following COVID-19 vaccination, as it may manifest with symptoms such as anterior neck pain, prolonged fever, or palpitations in recently vaccinated individuals, which should not be dismissed as common post-vaccination flu-like symptoms, thus enabling timely diagnosis and management.

CLINICAL CASE REPORTS (2021)

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Review Immunology

Acute Transverse Myelitis (ATM):Clinical Review of 43 Patients With COVID-19-Associated ATM and 3 Post-Vaccination ATM Serious Adverse Events With the ChAdOx1 nCoV-19 Vaccine (AZD1222)

Gustavo C. Roman et al.

Summary: Acute transverse myelitis has been unexpectedly found to be a frequent neurological complication of COVID-19, with symptoms including paralysis, sensory deficits, and sphincter dysfunction. The pathogenesis remains unknown, but it is hypothesized that SARS-CoV-2 antigens may induce immune mechanisms leading to myelitis.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Health Care Sciences & Services

A Rare Case of Cerebral Venous Thrombosis and Disseminated Intravascular Coagulation Temporally Associated to the COVID-19 Vaccine Administration

Vincenzo D'Agostino et al.

Summary: The global confirmed COVID-19 cases and deaths continue to increase, while vaccination efforts are progressing in different countries. Italy suspended the use of the AstraZeneca vaccine, but the European Medicines Agency concluded that the benefits of the vaccine outweigh the risks. A patient who developed severe thrombosis after vaccination ultimately died in intensive care.

JOURNAL OF PERSONALIZED MEDICINE (2021)

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Letter Allergy

COVID-19 vaccine anaphylaxis: IgE, complement or what else? A reply to: COVID-19 vaccine anaphylaxis: PEG or not?

Beatriz Cabanillas et al.

ALLERGY (2021)

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Letter Medicine, General & Internal

Severe Exacerbations of Systemic Capillary Leak Syndrome After COVID-19 Vaccination: A Case Series

Meghan Matheny et al.

ANNALS OF INTERNAL MEDICINE (2021)

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Article Cardiac & Cardiovascular Systems

Myocarditis and Pericarditis After COVID-19 mRNA Vaccination: Practical Considerations for Care Providers

Adriana Luk et al.

Summary: The mRNA vaccines against COVID-19 have been effective in reducing symptomatic cases globally, but cases of vaccine-related myocarditis/pericarditis have been reported, especially in male adolescents and young adults with symptom onset typically within 1 week after vaccination. A clinical framework is highlighted to guide providers on assessing, investigating, diagnosing, and reporting suspected and confirmed cases, with recommended standardized workup and imaging modalities such as echocardiography for unexplained elevations in troponin. Treatment is supportive, and diagnosis based on defined clinical criteria should be reported to public health authorities. Recommendations include vaccination in accordance with Health Canada and National Advisory Committee on Immunization guidelines, with deferral of a second dose for patients with suspected myocarditis/pericarditis after the first dose of an mRNA vaccine.

CANADIAN JOURNAL OF CARDIOLOGY (2021)

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Letter Dermatology

Asymmetrical cutaneous vasculitis following COVID-19 vaccination with unusual eosinophil preponderance

V. Kharkar et al.

CLINICAL AND EXPERIMENTAL DERMATOLOGY (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Unilateral axillary Adenopathy in the setting of COVID-19 vaccine

Nishi Mehta et al.

Summary: With the FDA approval and rollout of Pfizer-BioNTech and Moderna COVID-19 vaccines, radiologists should consider recent COVID-19 vaccination history when diagnosing patients with unilateral axillary adenopathy. Differential diagnosis should include hyperplastic axillary nodes induced by COVID-19 vaccination, and short-term follow-up is recommended over immediate axillary lymph node biopsies.

CLINICAL IMAGING (2021)

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Article Medicine, General & Internal

Lessons of the month 1: Longitudinal extensive transverse myelitis following AstraZeneca COVID-19 vaccination

Alp A. A. Notghi et al.

Summary: LETM, a rare complication of vaccination, was reported in a 58-year-old male 10 days after receiving the first dose of AstraZeneca COVID-19 vaccine. This case, unique in the UK, highlights the importance of considering LETM in the differential diagnosis following COVID-19 vaccination, particularly in patients with underlying conditions like pulmonary sarcoidosis.

CLINICAL MEDICINE (2021)

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Article Clinical Neurology

Guillain-Barre syndrome after AstraZeneca COVID-19-vaccination: A causal or casual association?

Alessandro Introna et al.

Summary: With the progress of COVID-19 vaccination campaigns, there has been an increase in reported cases of GBS related to vaccines. However, public health systems cannot afford unjustified distrust in vaccines due to misinterpretation of epidemiological data at this historical moment.

CLINICAL NEUROLOGY AND NEUROSURGERY (2021)

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Review Allergy

Anaphylaxis and Coronavirus Disease 2019 vaccine: a danger relationship?

Luciana Kase Tanno et al.

Summary: Anaphylactic reactions to SARS-CoV2 RNA vaccines are not more common than with other vaccines, and there is limited evidence for the role of its polyethylene glycol component. The risk of anaphylaxis post-vaccination is measured at 2.5-11/1 000 000, with only one case directly linked to polyethylene glycol. Surveillance programs are crucial for monitoring severe adverse reactions, emphasizing the importance of individualized investigation and care for specific cases.

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Letter Dermatology

COVID-19 vaccine-induced urticarial vasculitis

Siddhartha Dash et al.

DERMATOLOGIC THERAPY (2021)

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Review Dermatology

COVID-19 vaccines: What dermatologists should know?

Azin Ayatollahi et al.

Summary: This manuscript reviews different types of COVID-19 vaccines and their production platforms, discusses vaccination considerations in patients with skin diseases, and summarizes adverse cutaneous reactions of COVID-19 vaccines.

DERMATOLOGIC THERAPY (2021)

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Letter Dermatology

Cutaneous lymphocytic vasculitis after administration of COVID-19 mRNA vaccine

Camilla Vassallo et al.

DERMATOLOGIC THERAPY (2021)

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Article Infectious Diseases

Reports of anaphylaxis after coronavirus disease 2019 vaccination, South Korea, 26 February to 30 April 2021

Eunju Lee et al.

Summary: South Korea administered 3.8 million doses of COVID-19 vaccinations between February 26 and April 30, 2021, with 44 confirmed anaphylaxis cases out of 173 reported cases. The rates of anaphylaxis were 18.2 cases and 6.2 cases per million doses for Vaxzevria and Comirnaty, respectively. The median onset time was 14 minutes after vaccination, and most cases had recovered by the time of review.

EUROSURVEILLANCE (2021)

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Letter Medicine, General & Internal

Autoimmune hepatitis triggered by COVID-19

Jessica K. Hong et al.

INTERNAL MEDICINE JOURNAL (2021)

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Letter Dermatology

Atypical erythema multiforme related to BNT162b2 (Pfizer-BioNTech) COVID-19 vaccine

Cecilia Bujan Bonino et al.

INTERNATIONAL JOURNAL OF DERMATOLOGY (2021)

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Letter Dermatology

New-onset leukocytoclastic vasculitis after COVID-19 vaccine

Ecem Bostan et al.

INTERNATIONAL JOURNAL OF DERMATOLOGY (2021)

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Article Infectious Diseases

Anterior uveitis onset after bnt162b2 vaccination: is this just a coincidence?

Giulia Renisi et al.

Summary: A 23-year-old male developed anterior uveitis 14 days after receiving the second dose of BNT162b2 COVID-19 vaccine. Symptoms improved after a 10-day treatment course of topical steroids and cycloplegic eye drops, indicating a potential association between SARS-CoV-2 vaccination and eye inflammation.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2021)

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Article Medicine, General & Internal

Surveillance for Adverse Events After COVID-19 mRNA Vaccination

Nicola P. Klein et al.

Summary: This study conducted interim analysis of safety surveillance data of mRNA COVID-19 vaccines and found that the incidence of selected serious outcomes within 1-21 days post-vaccination was not significantly higher compared with 22-42 days post-vaccination. Surveillance is ongoing despite wide confidence intervals for many outcomes.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Letter Medicine, General & Internal

Myocarditis and Pericarditis After Vaccination for COVID-19

George A. Diaz et al.

Summary: This study compares the incidence of myocarditis and pericarditis in emergency department or inpatient hospital encounters before and during the period of COVID-19 vaccination availability in a large US health care system.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Article Immunology

Auto-immune hepatitis following COVID vaccination

Mohamed Rela et al.

Summary: The COVID pandemic has led to unprecedented loss of life and the rapid development of vaccines. While most vaccines have been approved quickly, there are concerns about their potential side effects, including rare cases of autoimmune hepatitis. Close monitoring and pharmacovigilance are essential in guiding treatment and ensuring vaccine safety.

JOURNAL OF AUTOIMMUNITY (2021)

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Article Endocrinology & Metabolism

Three Cases of Subacute Thyroiditis Following SARS-CoV-2 Vaccine: Postvaccination ASIA Syndrome

Burcin Gonul Iremli et al.

Summary: This study presents 3 cases of subacute thyroiditis after receiving the inactivated SARS-CoV-2 vaccine, describing the clinical, laboratory, and imaging features. The development of subacute thyroiditis occurred within a few days post-vaccination, with the possibility of being in the postpartum period facilitating the syndrome. This is the first report linking subacute thyroiditis to ASIA syndrome after COVID-19 vaccination.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2021)

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Review Clinical Neurology

A systematic review of Bell's Palsy as the only major neurological manifestation in COVID-19 patients

Sonia Gupta et al.

Summary: This paper evaluates reported cases of COVID-19 patients from March 2020 to December 2020 with Bell's palsy as the only major neurological manifestation, aiming to investigate the association between SARS-CoV2 and Bell's palsy.

JOURNAL OF CLINICAL NEUROSCIENCE (2021)

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Article Emergency Medicine

Bilateral Retinal Detachments in a Healthy 22-year-old Woman After Moderna SARS-COV-2 Vaccination

Rachna Subramony et al.

Summary: This case report describes a rare occurrence of simultaneous bilateral retinal detachments in a healthy young woman, with a possible association with receiving the COVID-19 vaccine. The case highlights the importance of awareness among emergency physicians for such situations and emphasizes the significance of ultrasonography in diagnosing time-sensitive medical conditions.

JOURNAL OF EMERGENCY MEDICINE (2021)

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Letter Gastroenterology & Hepatology

The mRNA COVID-19 vaccine - A rare trigger of autoimmune hepatitis?

Cathy McShane et al.

JOURNAL OF HEPATOLOGY (2021)

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Article Virology

Biphasic anaphylaxis after exposure to the first dose of Pfizer-BioNTech COVID-19 mRNA vaccine

Christophe Abi Zeid Daou et al.

Summary: Vaccination has become a major solution in the global pandemic of COVID-19, but it is important to remain vigilant for potential side effects and life-threatening complications. Anaphylactic cases post vaccination may have a recurrence of symptoms, highlighting the need for awareness. Recognizing the potential risk of anaphylaxis in select individuals and having appropriate measures in place to deal with adverse events is crucial.

JOURNAL OF MEDICAL VIROLOGY (2021)

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Article Clinical Neurology

A Case of Post-COVID-19-Associated Paracentral Acute Middle Maculopathy and Giant Cell Arteritis-Like Vasculitis

Go L. Jonathan et al.

Summary: A 47-year-old male patient with a history of COVID-19 infection presented with symptoms in the eye, later diagnosed with paracentral acute middle maculopathy. Despite developing temporal headache and jaw claudication, symptoms resolved quickly after high-dose steroid treatment, with normal test results for giant cell arteritis obtained afterwards. This case potentially implicates COVID-19 in both small and large vessel vasculitis in the ophthalmic setting.

JOURNAL OF NEURO-OPHTHALMOLOGY (2021)

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Article Immunology

A case of longitudinally extensive transverse myelitis following vaccination against Covid-19

Claudia Pagenkopf et al.

Summary: LETM is a rare subtype of TM that can lead to disability and is associated with neuromyelitis optica and other chronic demyelinating diseases of the central nervous system. While cases of TM following Covid-19 infection have been described, this is the first published case possibly related to Covid-19 vaccination.

JOURNAL OF NEUROIMMUNOLOGY (2021)

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Editorial Material Clinical Neurology

Ischaemic stroke can follow COVID-19 vaccination but is much more common with COVID-19 infection itself

Hugh S. Markus

Summary: Receiving COVID-19 vaccines may lead to vaccine-induced immune thrombotic thrombocytopaenia (VITT), resulting in thrombotic complications such as ischemic stroke and cerebral venous thrombosis.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2021)

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Review Clinical Neurology

Vaccine-induced immune thrombotic thrombocytopenia and cerebral venous sinus thrombosis post COVID-19 vaccination; a systematic review

Maryam Sharifian-Dorche et al.

Summary: CVST and VITT are rare but severe complications following COVID-19 vaccination, with most patients being female. Symptoms typically occur within one week after vaccination, with headache being the primary presenting symptom. Some patients may experience serious complications such as intracerebral hemorrhage.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2021)

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Letter Hematology

The statistical risk of diagnosing coincidental acquired hemophilia A following anti-SARS-CoV-2 vaccination

Micol G. Cittone et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2021)

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Letter Urology & Nephrology

IgA nephropathy presenting as macroscopic hematuria in 2 pediatric patients after receiving the Pfizer COVID-19 vaccine

Christian Hanna et al.

KIDNEY INTERNATIONAL (2021)

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Letter Urology & Nephrology

Gross hematuria following vaccination for severe acute respiratory syndrome coronavirus 2 in 2 patients with IgA nephropathy

Lavinia Negrea et al.

KIDNEY INTERNATIONAL (2021)

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Article Multidisciplinary Sciences

SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses

Jackson S. Turner et al.

Summary: SARS-CoV-2 mRNA vaccines induce a persistent germinal centre B cell response in humans, leading to the generation of robust humoral immunity, especially more significant in individuals previously infected with the virus.

NATURE (2021)

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Editorial Material Biochemistry & Molecular Biology

COVID-19 vaccination and immune thrombocytopenia

Allyson M. Pishko et al.

Summary: A study suggests a potential link between the AstraZeneca vaccine and an autoimmune disorder, immune thrombocytopenia, but further research is needed to establish causality.

NATURE MEDICINE (2021)

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Article Biochemistry & Molecular Biology

First-dose ChAdOx1 and BNT162b2 COVID-19 vaccines and thrombocytopenic, thromboembolic and hemorrhagic events in Scotland

C. R. Simpson et al.

Summary: Analysis of data from the EAVE II cohort in Scotland has shown that a first dose of the ChAdOx1 nCoV-19 vaccine may be associated with increased risks of idiopathic thrombocytopenic purpura, arterial thromboembolic events, and hemorrhagic events. However, there were no positive associations found between the BNT162b2 vaccine and these adverse events.

NATURE MEDICINE (2021)

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Letter Clinical Neurology

Guillain-Barre syndrome following BNT162b2 COVID-19 vaccine

Michele Trimboli et al.

NEUROLOGICAL SCIENCES (2021)

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Article Medicine, General & Internal

Safety of the BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Setting

Noam Barda et al.

Summary: The study found that after receiving the BNT162b2 vaccine, most adverse events were not associated with an increased risk, although there was a slight increase in the risk of myocarditis. On the other hand, infection with the Covid-19 virus significantly increased the risk of many serious adverse events.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Letter Ophthalmology

Bilateral Multifocal Choroiditis following COVID-19 Vaccination

Mallika Goyal et al.

Summary: This case report highlights a rare occurrence of bilateral choroiditis following COVID-19 vaccination, suggesting an inflammatory or autoimmune response. Prompt diagnosis and treatment with corticosteroids can lead to rapid improvement in visual outcomes for patients experiencing ocular symptoms post-vaccination.

OCULAR IMMUNOLOGY AND INFLAMMATION (2021)

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Letter Ophthalmology

Acute Macular Neuroretinopathy following Coronavirus Disease 2019 Vaccination

Manuela Mambretti et al.

Summary: Two young women developed acute macular neuroretinopathy (AMN) two days after receiving the Vaxzevria COVID-19 vaccination. Retinal imaging confirmed AMN in both cases. Both patients were on oral contraceptives and had no history of COVID-19. Vaccination may represent a possible risk factor for AMN onset in women on oral contraceptives.

OCULAR IMMUNOLOGY AND INFLAMMATION (2021)

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Article Ophthalmology

Panuveitis following Vaccination for COVID-19

Lucy I. Mudie et al.

Summary: This report describes a case of panuveitis following the Pfizer-Biotech mRNA COVID-19 vaccine, with improvement noted after treatment with corticosteroids but mild recurrence after drug tapering.

OCULAR IMMUNOLOGY AND INFLAMMATION (2021)

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Editorial Material Medicine, General & Internal

IgA nephropathy flare-up following SARS-CoV-2 vaccination

T. Horino

QJM-AN INTERNATIONAL JOURNAL OF MEDICINE (2021)

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Letter Hematology

Autoimmunity after Coronavirus Disease 2019 (COVID-19) Vaccine: A Case of Acquired Hemophilia A

Scott Farley et al.

THROMBOSIS AND HAEMOSTASIS (2021)

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Article Dermatology

Hyaluronic acid soft tissue filler delayed inflammatory reaction following COVID-19 vaccination - A case report

Alain Michon

Summary: This case report presents two cases of delayed reactions in patients who had previously received hyaluronic acid soft tissue fillers after receiving COVID-19 mRNA vaccination. While such reactions are rare and typically self-limited, aesthetic providers should be aware of the potential risks posed by the interaction of these vaccines in patients who have had or seek hyaluronic acid soft tissue filler injections, especially in the current pandemic scenario with high global demand for COVID-19 vaccines.

JOURNAL OF COSMETIC DERMATOLOGY (2021)

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Letter Dermatology

Cutaneous small-vessel vasculitis following COVID-19 vaccine

Bikash Ranjan Kar et al.

JOURNAL OF COSMETIC DERMATOLOGY (2021)

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Article Medicine, General & Internal

Characterising the background incidence rates of adverse events of special interest for covid-19 vaccines in eight countries: multinational network cohort study

Xintong Li et al.

Summary: This study highlights significant variations in the background incidence rates of 15 prespecified adverse events associated with covid-19 vaccines across different databases. Certain adverse events increase with age, while others are more prevalent in younger individuals. Meta-analytic estimates of adverse event rates have been classified by age and sex.

BMJ-BRITISH MEDICAL JOURNAL (2021)

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Article Biotechnology & Applied Microbiology

Electromyoneurography and laboratory findings in a case of Guillain-Barre syndrome after second dose of Pfizer COVID-19 vaccine

Roberto Scendoni et al.

Summary: Guillain-Barre syndrome (GBS) is an acute immune-mediated disease that can be triggered by infections, including after receiving COVID-19 vaccination. Clinicians must quickly recognize associated neurological complications in the ongoing mass vaccination campaign.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2021)

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Article Biotechnology & Applied Microbiology

Reactive arthritis after COVID-19 vaccination

Qi-jun An et al.

Summary: Reactive arthritis (ReA) following COVID-19 vaccination is rare but the benefits of vaccination outweigh potential risks. Future attention should focus on identifying individuals at higher risk for developing autoimmune diseases after COVID-19 vaccination and exploring more versatile and safer vaccines.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2021)

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Article Biotechnology & Applied Microbiology

Subacute thyroiditis following COVID-19 vaccination in a 67-year-old male patient: a case report

Melisa Sahin Tekin et al.

Summary: Subacute thyroiditis is the most common cause of painful thyroid gland diseases, characterized by inflammation of the thyroid gland and often occurring after viral upper respiratory tract infections. COVID-19 and vaccines are also associated with cases of subacute thyroiditis.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2021)

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Article Ophthalmology

Association of Ocular Adverse Events With Inactivated COVID-19 Vaccination in Patients in Abu Dhabi

Francesco Pichi et al.

Summary: A case series study of 7 patients who experienced ocular adverse events after receiving an inactivated COVID-19 vaccine showed transient ocular complications occurring on average 5.2 days post-vaccination, including episcleritis, anterior scleritis, acute macular neuroretinopathy, and others.

JAMA OPHTHALMOLOGY (2021)

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Editorial Material Ophthalmology

Bilateral Acute Macular Neuroretinopathy After Vaccination Against SARS-CoV-2

Benedikt A. J. Book et al.

JAMA OPHTHALMOLOGY (2021)

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Article Medicine, General & Internal

Case Report: Two Cases of Subacute Thyroiditis Following SARS-CoV-2 Vaccination

Catherine Bornemann et al.

Summary: The article reports two cases of subacute thyroiditis following SARS-CoV-2 vaccination, both presenting symptoms 2 weeks after vaccination with anterior and lateral neck pain. Clinical test results and cytological findings were consistent with subacute thyroiditis.

FRONTIERS IN MEDICINE (2021)

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Article Hematology

Autoimmune- and complement-mediated hematologic condition recrudescence following SARS-CoV-2 vaccination

Andrew Jay Portuguese et al.

Summary: This article discusses the recurrence of autoimmune and complement-mediated hematologic conditions after COVID-19 vaccination, presenting three illustrative cases. It describes the exacerbation of immune thrombocytopenia, acquired von Willebrand Disease/acquired hemophilia A, and paroxysmal nocturnal hemoglobinuria following SARS-CoV-2 vaccination. It highlights the need for monitoring and risk assessment in patients with underlying autoimmune and complement-mediated hematologic conditions.

BLOOD ADVANCES (2021)

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Letter Immunology

Fatal Systemic Capillary Leak Syndrome after SARS-CoV-2 Vaccination in Patient with Multiple Myeloma

Gwang-Jun Choi et al.

Summary: This report describes a case of severe adverse reaction after COVID-19 vaccination, potentially linked to the patient's history of systemic capillary leak syndrome.

EMERGING INFECTIOUS DISEASES (2021)

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Article Urology & Nephrology

IgA Nephropathy After SARS-CoV-2 Vaccination

Matthew Abramson et al.

Summary: This case report presents the first diagnosed case of IgA nephropathy following SARS-CoV-2 vaccination, suggesting a potential immunological mechanism and emphasizing the importance of understanding and monitoring immune responses.

KIDNEY MEDICINE (2021)

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Article Infectious Diseases

Kikuchi-Fujimoto disease following SARS CoV2 vaccination: Case report

Hussam Al Soub et al.

Summary: Kikuchi-Fujimoto disease is a benign self-limited condition characterized by cervical lymphadenopathy or fever of unknown origin, with symptoms usually resolving within one to four months.

IDCASES (2021)

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Article Ophthalmology

Vogt-Koyanagi-Harada Syndrome following COVID-19 and ChAdOx1 nCoV-19 (AZD1222) vaccine

Janaina Jamile Ferreira Saraceno et al.

Summary: The challenge of COVID-19 has brought significant changes to global medical management, leading to a rapid development of vaccines. This study presents two cases of VKH syndrome following SARS-CoV-2 vaccination, suggesting a potential causal relationship between COVID-19 and uveitis.

INTERNATIONAL JOURNAL OF RETINA AND VITREOUS (2021)

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Article Medicine, General & Internal

Bilateral Facial Nerve Palsy and COVID-19 Vaccination: Causation or Coincidence?

Matthew C. Mason et al.

Summary: Bell's palsy is a unilateral facial paralysis caused by a mononeuropathy of the facial nerve, with bilateral cases being rare. While most cases of unilateral Bell's palsy are idiopathic, bilateral cases typically have identifiable triggers. A recent case report highlighted a potential correlation between the COVID-19 vaccine and bilateral Bell's palsy in a patient with no identifiable etiology after thorough investigation.

CUREUS JOURNAL OF MEDICAL SCIENCE (2021)

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Article Clinical Neurology

A Novel Case of Bifacial Diplegia Variant of Guillain-Barre Syndrome Following Janssen COVID-19 Vaccination

Apoorv Prasad et al.

Summary: Guillain-Barre syndrome (GBS) is an immune-mediated demyelinating disorder affecting the peripheral nervous system, characterized by symmetric, rapidly progressive paralysis. There have been reports linking COVID-19 vaccination to rare complications such as GBS.

NEUROLOGY INTERNATIONAL (2021)

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Review Medicine, General & Internal

New-onset Nephrotic Syndrome after Janssen COVID-19 Vaccination: a Case Report and Literature Review

Jeong Hoon Lim et al.

Summary: A 51-year-old man developed nephrotic syndrome secondary to minimal change disease after receiving the Ad26.COV.2 (Janssen) vaccine. Clinicians should be cautious about potential renal effects of COVID-19 vaccines.

JOURNAL OF KOREAN MEDICAL SCIENCE (2021)

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Article Medicine, General & Internal

A Case of Acquired Hemophilia A Following SARS-CoV-2 Infection

Husam Hafzah et al.

Summary: Acquired hemophilia A is a rare bleeding disorder caused by antibodies against coagulation factor VIII. It is often under-diagnosed due to limited data. This report describes a patient who developed AHA after a COVID-19 infection, with excellent response to treatment.

CUREUS JOURNAL OF MEDICAL SCIENCE (2021)

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Review Allergy

COVID-19 Vaccine-associated Anaphylaxis and Allergic Reactions: Consensus Statements of the KAAACI Urticaria/Angioedema/Anaphylaxis Working Group

Mi Ae Kim et al.

Summary: In the era of the novel coronavirus epidemics, COVID-19 vaccines have been recognized as one of the most effective public health interventions to control the pandemic. However, severe allergic reactions can occur after vaccinations, with potential allergenic/immunogenic excipients such as PEG and polysorbate 80 in COVID-19 vaccines. Contraindications to vaccination include a history of severe allergic reactions to the vaccine or proven hypersensitivity to a vaccine component.

ALLERGY ASTHMA & IMMUNOLOGY RESEARCH (2021)

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Article Immunology

Fight against COVID-19 with mRNA vaccines and interaction with Dermal fillers

Shohreh Ghasemi et al.

Summary: The COVID-19 outbreak has led to a demand for rapid and high-volume vaccine manufacturing, with mRNA vaccine platform technology showing great promise in meeting this need.

CLINICAL AND EXPERIMENTAL VACCINE RESEARCH (2021)

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Article Ophthalmology

COVID-19 Recombinant mRNA Vaccines and Serious Ocular Inflammatory Side Effects: Real or Coincidence?

Arash Maleki et al.

Summary: This report presents two cases of retinal and optic nerve disorders following COVID-19 mRNA vaccination, with one case of bilateral AAION and the other of bilateral AZOOR.

JOURNAL OF OPHTHALMIC & VISION RESEARCH (2021)

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Article Medicine, General & Internal

Subacute Thyroiditis After Receiving the Adenovirus-Vectored Vaccine for Coronavirus Disease (COVID-19)

Samson O. Oyibo

Summary: Subacute thyroiditis occurring after COVID-19 vaccination is rare but probably underreported.

CUREUS JOURNAL OF MEDICAL SCIENCE (2021)

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Letter Endocrinology & Metabolism

Myocardial infarction after COVID-19 vaccination-casual or causal?

Subhankar Chatterjee et al.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2021)

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Article Medicine, General & Internal

Secondary immune thrombocytopenia supposedly attributable to COVID-19 vaccination

Omar Fueyo-Rodriguez et al.

Summary: There have been reports of ITP as a complication of SARS-CoV-2 infection, but as of now, there have been no reports on the association of the COVID-19 vaccine with thrombocytopenia. Here we present a case of secondary ITP in a patient who recently received the mRNA COVID-19 vaccine BNT162b2 (Pfizer-BioNTech).

BMJ CASE REPORTS (2021)

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Article Medicine, General & Internal

Untimely Myocardial Infarction or COVID-19 Vaccine Side Effect

Zachary Boivin et al.

Summary: Healthcare providers should be cautious about correlating adverse outcomes with vaccination without proper data support, and be prepared to address patient inquiries based on such reports. Research on the topic should be conducted carefully without exaggerated claims, and additional screenings may be necessary for older adults before COVID-19 vaccination if serious side effects are reported.

CUREUS JOURNAL OF MEDICAL SCIENCE (2021)

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Article Medicine, General & Internal

Neurological Complications of COVID-19: Guillain-Barre Syndrome Following Pfizer COVID-19 Vaccine

Sadia Waheed et al.

Summary: Since December 2019, COVID-19 has caused global pandemic with multiple neurological complications, including a reported case of Guillain-Barre Syndrome (GBS) following the administration of Pfizer - COVID-19 vaccine.

CUREUS JOURNAL OF MEDICAL SCIENCE (2021)

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Review Endocrinology & Metabolism

Subacute Thyroiditis from COVID-19 Infection: A Case Report and Review of Literature

Akshay Khatri et al.

Summary: The novel coronavirus SARS-CoV-2 has triggered a global pandemic of COVID-19, with increasing reports of extrapulmonary manifestations. This study highlights a case of subacute thyroiditis precipitated by COVID-19 infection, emphasizing the importance of recognizing and managing potential thyroid dysfunction in post-COVID-19 patients. Early identification and appropriate anti-inflammatory therapy are crucial for successful outcomes.

EUROPEAN THYROID JOURNAL (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Vasculitis changes in COVID-19 survivors with persistent symptoms: an [18F]FDG-PET/CT study

Martina Sollini et al.

Summary: The study included 10 COVID-19 recovered patients with persistent symptoms, showing increased [F-18]FDG uptake in bone marrow and blood vessels. Compared to controls, the recovered patients had higher [F-18]FDG uptake ratios, indicating that SARS-CoV-2 may induce vascular inflammation leading to persisting symptoms.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2021)

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Article Endocrinology & Metabolism

Three Cases of Subacute Thyroiditis Following SARS-CoV-2 Vaccine: Postvaccination ASIA Syndrome

Burcin Gonul Iremli et al.

Summary: This study reports three cases of subacute thyroiditis related to the COVID-19 vaccine, which may develop within a few days post-vaccination. Being in the postpartum period may facilitate the development of ASIA syndrome after COVID-19 vaccination. Clinicians should be aware of the possibility of subacute thyroiditis as a manifestation of ASIA syndrome following COVID-19 vaccination.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2021)

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Article Clinical Neurology

Clinical and radiological characteristics and predictors of outcome of cerebral venous sinus thrombosis, a hospital-based study

Banafsheh Shakibajahromi et al.

ACTA NEUROLOGICA BELGICA (2020)

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Article Immunology

Erythema multiforme, Stevens Johnson syndrome, and toxic epidermal necrolysis reported after vaccination, 1999-2017

John R. Su et al.

VACCINE (2020)

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Letter Hematology

COVID-19-associated immune thrombocytopenia

Gienke Bomhof et al.

BRITISH JOURNAL OF HAEMATOLOGY (2020)

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Article Endocrinology & Metabolism

Subacute Thyroiditis After Sars-COV-2 Infection

Alessandro Brancatella et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2020)

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Letter Clinical Neurology

Acute transverse myelitis after COVID-19 pneumonia

Maike Munz et al.

JOURNAL OF NEUROLOGY (2020)

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Letter Infectious Diseases

COVID-19 as a cause of immune thrombocytopenia

S. Humbert et al.

MEDECINE ET MALADIES INFECTIEUSES (2020)

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Editorial Material Critical Care Medicine

Systemic Capillary Leak Syndrome Secondary to Coronavirus Disease 2019

Robert Case et al.

CHEST (2020)

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Letter Hematology

Clinical characteristics, management and outcome of COVID-19-associated immune thrombocytopenia: a French multicentre series

Matthieu Mahevas et al.

BRITISH JOURNAL OF HAEMATOLOGY (2020)

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Letter Dermatology

Urticarial vasculitis in a COVID-19 recovered patient

Soheila Nasiri et al.

INTERNATIONAL JOURNAL OF DERMATOLOGY (2020)

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Article Hematology

Immune thrombocytopenia in a patient with COVID-19

Emilie Deruelle et al.

INTERNATIONAL JOURNAL OF HEMATOLOGY (2020)

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Letter Endocrinology & Metabolism

A case of subacute thyroiditis associated with Covid-19 infection

E. Asfuroglu Kalkan et al.

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION (2020)

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Article Medicine, General & Internal

Immune Thrombocytopenia in a Very Elderly Patient With Covid-19

Fehmi Hindilerden et al.

FRONTIERS IN MEDICINE (2020)

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Letter Ophthalmology

Covid-19-Associated Retinopathy: A Case Report

Pierre Gascon et al.

OCULAR IMMUNOLOGY AND INFLAMMATION (2020)

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Article Clinical Neurology

Cerebral venous sinus thrombosis associated with SARS-CoV-2; a multinational case series

Ashkan Mowla et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2020)

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Article Urology & Nephrology

Clinical and pathological findings of SARS-CoV-2 infection and concurrent IgA nephropathy: a case report

Yi Huang et al.

BMC NEPHROLOGY (2020)

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Article Medicine, General & Internal

Acute immune thrombocytopaenic purpura in a patient with COVID-19 and decompensated cirrhosis

Florent Artru et al.

BMJ CASE REPORTS (2020)

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Do we miss rare adverse events induced by COVID-19 vaccination?

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