Journal
METABOLITES
Volume 12, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/metabo12090867
Keywords
alcoholic liver disease (ALD); antioxidant; anti-inflammatory; galacto-oligosaccharide; hepatoprotective
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Funding
- Science and Technology Program of Guangzhou, China [202103000089]
- Guangdong Demonstration Base for Joint Cultivation of Postgraduates
- Science Foundation for Distinguished Young Scholars of Guangdong [2020B1515020026]
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Galacto-oligosaccharide (GOS) may be a potential functional food for the prevention and treatment of alcoholic liver disease (ALD) due to its protective mechanism involving antioxidant and anti-inflammatory activities.
Alcoholic liver disease (ALD) is a primary cause of mortality and morbidity worldwide. Oxidative stress and inflammation are important pathogenic factors contributing to ALD. We investigated the protective mechanism of galacto-oligosaccharide (GOS) against ALD through their antioxidant and anti-inflammatory activities by performing in vivo and in vitro experiments. Western blot and RT-PCR results indicated that the expression of cytochrome P450 protein 2E1 (CYP2E1) in liver tissues and L02 cells was reduced in the GOS-treated mice compared with the model group. In addition, GOS prominently reduced the expression of Kelch-like ECH-associated protein 1 (Keap1), increased the expression of the nuclear factor erythroid-2-related factor 2 (Nrf2) and haem oxygenase-1 (HO-1) proteins, and enhanced the antioxidant capacity. In addition, GOS decreased inflammation by reducing inflammatory factor levels and inhibiting the mitogen-activated protein kinase (MAPK)/nuclear factor kappa B (NF-kappa B) pathway. Based on these results, GOS may be a prospective functional food for the prevention and treatment of ALD.
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