4.6 Review

Micellization: A new principle in the formation of biomolecular condensates

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Hybridization-proximity labeling reveals spatially ordered interactions of nuclear RNA compartments

Karen Yap et al.

Summary: This study introduces a set of labeling technologies for the unbiased discovery of proteins and transcripts associated with specific RNAs. These technologies can identify both known and unknown molecules that interact with the RNA of interest. The study also reveals a large repertoire of incompletely processed, edited transcripts accumulating between chromosomal regions and RNA-containing compartments. Overall, this versatile tool-kit expands our understanding of the functional architecture of the mammalian nucleus.

MOLECULAR CELL (2022)

Editorial Material Biochemistry & Molecular Biology

RNA in formation and regulation of transcriptional condensates

Phillip A. Sharp et al.

Summary: This brief article summarizes the importance of condensates in transcription regulation and the role of RNA molecules in such condensates. Models and experimental data suggest that RNA facilitates the formation of condensates and stabilizes the binding of transcription factors, resulting in a burst of transcription activity.
Article Biochemistry & Molecular Biology

RNA is required for the integrity of multiple nuclear and cytoplasmic membrane-less RNP granules

Carolyn J. Decker et al.

Summary: This study shows that the degradation of RNA components has a significant impact on the majority of RNP granules, including SGs, Cajal bodies, nuclear speckles, and the nucleolus, highlighting the critical and widespread role of RNA in the organization of these organelles. PBs and super-enhancer complexes, on the other hand, are largely unaffected by RNA degradation, suggesting a different mechanism of organization for these structures.

EMBO JOURNAL (2022)

Review Biochemistry & Molecular Biology

ArcRNAs and the formation of nuclear bodies

Shinichi Nakagawa et al.

Summary: Long noncoding RNAs (lncRNAs) have been classified into different functional categories, including Architectual RNAs (arcRNAs) that serve as structural components of cellular bodies or nonmembranous organelles. In the nucleus, arcRNAs play a crucial role in providing a structural basis for the formation of nuclear bodies.

MAMMALIAN GENOME (2022)

Article Biochemistry & Molecular Biology

Species-specific formation of paraspeckles in intestinal epithelium revealed by characterization of NEAT1 in naked mole-rat

Akihiro Yamada et al.

Summary: Paraspeckles are nuclear bodies built on the long noncoding RNA NEAT1_2. The expression pattern of NEAT1_2 in naked mole-rats (nNEAT1_2) was investigated, and it was found that nNEAT1_2 recruits a different set of RNA binding proteins, compared to humans and mice, during the formation of paraspeckles. The absence of the FUS protein and the expression of other FET family proteins were observed in naked mole-rats.
Article Cell Biology

Genetic variation associated with condensate dysregulation in disease

Salman F. Banani et al.

Summary: This study comprehensively maps pathogenic mutations related to condensates and finds that these mutations may lead to condensate dysregulation, affecting a wide range of human diseases. These findings provide a foundation for researching disease mechanisms and treatments.

DEVELOPMENTAL CELL (2022)

Article Biochemistry & Molecular Biology

A conceptual framework for understanding phase separation and addressing open questions and challenges

Tanja Mittag et al.

Summary: Macromolecular phase separation plays an important role in the spatial organization within cells. By understanding the synergy between networking and density transitions, we can explain the process of phase separation coupled to percolation (PSCP). This process forms viscoelastic network fluids with specific internal network structures, allowing for time-dependent interactions between viscous and elastic properties. PSCP provides insights into the role of macromolecular phase separation in biology by connecting different observations and addressing related challenges.

MOLECULAR CELL (2022)

Article Biochemistry & Molecular Biology

Triblock copolymer micelle model of spherical paraspeckles

Tetsuya Yamamoto et al.

Summary: Paraspeckles are nuclear bodies formed by NEAT1_2 RNA transcripts and RNA-binding proteins. Using a theoretical model based on block copolymer micelles, researchers have found that the core-shell structure of paraspeckles is assembled through multivalent interactions between different regions of NEAT1_2 RNP complexes and the affinity of these complexes to the nucleoplasm. The structure of paraspeckles is robust in the wild type, but can be significantly affected by thermal fluctuations in a mutant where a part of the NEAT1_2 terminal regions is deleted.

FRONTIERS IN MOLECULAR BIOSCIENCES (2022)

Article Biochemistry & Molecular Biology

NEAT1 polyA-modulating antisense oligonucleotides reveal opposing functions for both long non-coding RNA isoforms in neuroblastoma

Alina Naveed et al.

Summary: Numerous lncRNAs, including NEAT1, are dysregulated in cancer and are considered therapeutic targets. Researchers have developed ASOs targeting NEAT1_1 to increase NEAT1_2 expression and paraspeckle abundance in neuroblastoma cells, leading to a decrease in cell viability in high-risk neuroblastoma. Furthermore, altering lncRNA polyadenylation events using ASOs shows potential as an anti-cancer strategy.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

Review Cell Biology

RNA contributions to the form and function of biomolecular condensates

Christine Roden et al.

Summary: Recent studies have shown the significant contribution of RNA to cellular liquid-liquid phase separation and condensate formation, which play important roles in various cellular functions such as RNA transport, supporting catalytic processes, and stress responses. Although RNA and RNA-protein condensates are important in cells, the role of RNA in liquid-liquid phase separation has received less attention in comparison to RNA-binding proteins.Properties such as composition, length, structure, modifications, and expression levels of RNA can modulate the biophysical features of native condensates, influencing their size, shape, viscosity, and composition. RNA-protein condensates are involved in various cellular functions, including cell compartmentalization through RNA transport and localization, supporting catalytic processes, storage and inheritance of specific molecules, as well as buffering noise and responding to stress.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

Review Cell Biology

The nucleolus as a multiphase liquid condensate

Denis L. J. Lafontaine et al.

Summary: The nucleolus is a membraneless organelle involved in ribonucleoprotein assembly, with recent studies suggesting that it forms as a biomolecular condensate via liquid-liquid phase separation (LLPS). Insights from LLPS studies are enhancing our understanding of the nucleolar structure-function relationship.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

Article Biochemistry & Molecular Biology

RNA promotes the formation of spatial compartments in the nucleus

Sofia A. Quinodoz et al.

Summary: Research shows that RNA and DNA play crucial roles in the spatial organization within the nucleus. Through the use of RD-SPRITE technology, the connections between RNA and chromatin structures have been revealed, providing a comprehensive analysis of nuclear functions.
Article Multidisciplinary Sciences

The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein

Shan Lu et al.

Summary: The SARS-CoV-2 nucleocapsid (N) protein binds viral RNA and undergoes liquid-liquid phase separation driven by its central intrinsically-disordered region, modulated by phosphorylation. Additionally, the N protein interacts with the membrane protein M to form mutually exclusive compartments in a three-component mixture with RNA.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

Transcription organizes euchromatin via microphase separation

Lennart Hilbert et al.

Summary: This study observed the dynamics of euchromatin organization in pluripotent zebrafish cells during transcription initiation, revealing that accumulation of RNA induces the formation of transcriptionally active regions that tend to separate from transcriptionally inactive euchromatin, forming smaller scale microphases.

NATURE COMMUNICATIONS (2021)

Review Biochemistry & Molecular Biology

Paraspeckle nuclear condensates: Global sensors of cell stress?

Finn McCluggage et al.

Summary: Cells increase paraspeckles in response to various stresses to aid pro-survival pathways, suggesting a crucial role for paraspeckles in cellular homeostasis during times of flux.

BIOESSAYS (2021)

Article Biochemistry & Molecular Biology

Paraspeckles are constructed as block copolymer micelles

Tomohiro Yamazaki et al.

Summary: Paraspeckles are assembled by NEAT1_2 architectural long noncoding RNAs as block copolymer micelles through a type of microphase separation called micellization. This study provides an experiment-based theoretical framework demonstrating that ribonucleoprotein complexes can act as block copolymers to form RNA-scaffolding biomolecular condensates with optimal sizes and structures in cells.

EMBO JOURNAL (2021)

Article Multidisciplinary Sciences

The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA

Jasmine Cubuk et al.

Summary: The study reveals that SARS-CoV-2 nucleocapsid (N) protein undergoes liquid-liquid phase separation with RNA, and provides molecular details of N protein through single-molecule spectroscopy with all-atom simulations, showing its multivalent RNA-binding nature and interactions that may drive RNA compaction.

NATURE COMMUNICATIONS (2021)

Article Oncology

N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation

Yuanming Cheng et al.

Summary: The study revealed the crucial role of m(6)A in myeloid leukemia, where it maintains cell survival and the undifferentiated state necessary for leukemia maintenance through the formation of nuclear YTHDC1-m(6)A condensates.

CANCER CELL (2021)

Article Biochemistry & Molecular Biology

m6A modification of HSATIII lncRNAs regulates temperature-dependent splicing

Kensuke Ninomiya et al.

Summary: The study reveals the role of nuclear stress bodies in repressing RNA splicing during stress recovery through two distinct mechanisms involving protein sequestration and N-6-methyladenosine modification. The sequestration of m(6)A writer complex by nSBs leads to the inhibition of m(6)A-dependent splicing, highlighting the importance of nSBs in regulating temperature-dependent splicing.

EMBO JOURNAL (2021)

Article Chemistry, Physical

Phase separation vs aggregation behavior for model disordered proteins

Ushnish Rana et al.

Summary: The study on liquid-liquid phase separation (LLPS) of proteins through Monte Carlo simulations reveals that LLPS is influenced by factors such as sequence distribution, sticker fraction, and chain length. The normalized sequence charge decoration (SCD) parameter can predict whether a protein will undergo macroscopic phase separation or finite aggregation. Results show that at sufficiently long chain lengths, most sequences are likely to undergo phase separation.

JOURNAL OF CHEMICAL PHYSICS (2021)

Article Biochemistry & Molecular Biology

Enhancer RNA m6A methylation facilitates transcriptional condensate formation and gene activation

Joo-Hyung Lee et al.

Summary: The study reveals the heavy but selective deposition of m6A on nascent RNAs produced by transcription regulatory elements, and shows that m6A-eRNAs mark highly active enhancers by recruiting YTHDC1 and promoting condensate formation. This mechanism plays broad roles in enhancer activation and gene transcriptional control.

MOLECULAR CELL (2021)

Article Multidisciplinary Sciences

NORAD-induced Pumilio phase separation is required for genome stability

Mahmoud M. Elguindy et al.

Summary: Liquid-liquid phase separation is a key mechanism through which long noncoding RNA controls RNA-binding proteins and maintains genomic stability in mammalian cells. The study shows that RNA-driven phase separation competitively sequesters RNA-binding proteins by nucleating the formation of phase-separated condensates, influencing RBP activity and genome maintenance. The repetitive sequence architecture of lncRNAs suggests that phase separation may be a widely used mechanism of lncRNA-mediated regulation.

NATURE (2021)

Article Biochemistry & Molecular Biology

hnRNPH1-MTR4 complex-mediated regulation of NEAT1v2 stability is critical for IL8 expression

Tanzina Tanu et al.

Summary: This study demonstrates that hnRNPH1 regulates the expression of the IL8 gene by controlling the degradation of NEAT1v2, thereby influencing the innate immune response of cells.

RNA BIOLOGY (2021)

Editorial Material Multidisciplinary Sciences

Control of condensates dictates nucleolar architecture

Tomohiro Yamazaki et al.

SCIENCE (2021)

Article Multidisciplinary Sciences

Regulation of biomolecular condensates by interfacial protein clusters

Andrew W. Folkmann et al.

Summary: This study reveals that the dynamics of biomolecular condensates are regulated by protein clusters. Through experiments and theory, it is demonstrated that the assembly of P granules is controlled by MEG-3 protein, which helps lower surface tension and slow down coarsening.

SCIENCE (2021)

Editorial Material Multidisciplinary Sciences

Getting droplets into shape

Wilton T. Snead et al.

SCIENCE (2021)

Review Cell Biology

A framework for understanding the functions of biomolecular condensates across scales

Andrew S. Lyon et al.

Summary: Biomolecular condensates are membraneless molecular assemblies formed via liquid-liquid phase separation, playing important roles in controlling biochemical reactions and regulating cell organization and function throughout eukaryotic cells.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

Article Biochemistry & Molecular Biology

LncRNA-dependent nuclear stress bodies promote intron retention through SR protein phosphorylation

Kensuke Ninomiya et al.

EMBO JOURNAL (2020)

Review Biochemistry & Molecular Biology

RNA toxicity in non-coding repeat expansion disorders

Bart Swinnen et al.

EMBO JOURNAL (2020)

Article Biochemistry & Molecular Biology

ARS2 Regulates Nuclear Paraspeckle Formation through 3′-End Processing and Stability of NEAT1 Long Noncoding RNA

Mitsuhiro Machitani et al.

MOLECULAR AND CELLULAR BIOLOGY (2020)

Article Multidisciplinary Sciences

Analyses of non-coding somatic drivers in 2,658 cancer whole genomes

Esther Rheinbay et al.

NATURE (2020)

Article Physics, Multidisciplinary

Elastic ripening and inhibition of liquid-liquid phase separation

Kathryn A. Rosowski et al.

NATURE PHYSICS (2020)

Article Multidisciplinary Sciences

RADICL-seq identifies general and cell type-specific principles of genome-wide RNA-chromatin interactions

Alessandro Bonetti et al.

NATURE COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization

David W. Sanders et al.

Article Biochemistry & Molecular Biology

G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules

Peiguo Yang et al.

Article Biochemistry & Molecular Biology

RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation

Jordina Guillen-Boixet et al.

Review Genetics & Heredity

Phase separation drives pairing of homologous chromosomes

Yasushi Hiraoka

CURRENT GENETICS (2020)

Article Multidisciplinary Sciences

RIC-seq for global in situ profiling of RNA-RNA spatial interactions

Zhaokui Cai et al.

NATURE (2020)

Editorial Material Biology

Phase Separation: Restricting the sizes of condensates

Furqan Dar et al.

ELIFE (2020)

Article Multidisciplinary Sciences

Integrator restrains paraspeckles assembly by promoting isoform switching of the lncRNA NEAT1

Jasmine Barra et al.

SCIENCE ADVANCES (2020)

Review Biochemistry & Molecular Biology

Biomolecular Condensates in the Nucleus

Benjamin R. Sabari et al.

TRENDS IN BIOCHEMICAL SCIENCES (2020)

Article Biochemistry & Molecular Biology

Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid

Christiane Iserman et al.

MOLECULAR CELL (2020)

Article Multidisciplinary Sciences

Nucleocapsid protein of SARS-CoV-2 phase separates into RNA-rich polymerase-containing condensates

Adriana Savastano et al.

NATURE COMMUNICATIONS (2020)

Review Biochemistry & Molecular Biology

Short Tandem Repeat-Enriched Architectural RNAs in Nuclear Bodies: Functions and Associated Diseases

Kensuke Ninomiya et al.

NON-CODING RNA (2020)

Article Biochemistry & Molecular Biology

Cross-Regulation between TDP-43 and Paraspeckles Promotes Pluripotency-Differentiation Transition

Miha Modic et al.

MOLECULAR CELL (2019)

Editorial Material Multidisciplinary Sciences

Phase separation in biology and disease-a symposium report

Jennifer Cable et al.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2019)

Article Multidisciplinary Sciences

RNA is a critical element for the sizing and the composition of phase-separated RNA-protein condensates

Marina Garcia-Jove Navarro et al.

NATURE COMMUNICATIONS (2019)

Article Cell Biology

Stress granules regulate stress-induced paraspeckle assembly

Haiyan An et al.

JOURNAL OF CELL BIOLOGY (2019)

Article Multidisciplinary Sciences

The Eleanor ncRNAs activate the topological domain of the ESR1 locus to balance against apoptosis

Mohamed Osama Ali Abdalla et al.

NATURE COMMUNICATIONS (2019)

Article Biochemistry & Molecular Biology

Isolation and genome-wide characterization of cellular DNA:RNA triplex structures

Nevcin Sentuerk Cetin et al.

NUCLEIC ACIDS RESEARCH (2019)

Article Biotechnology & Applied Microbiology

PIRCh-seq: functional classification of non-coding RNAs associated with distinct histone modifications

Jingwen Fang et al.

GENOME BIOLOGY (2019)

Article Biochemistry & Molecular Biology

Diminished nuclear RNA decay upon Salmonella infection upregulates antibacterial noncoding RNAs

Katsutoshi Imamura et al.

EMBO JOURNAL (2018)

Article Biochemistry & Molecular Biology

Functional Domains of NEAT1 Architectural lncRNA Induce Paraspeckle Assembly through Phase Separation

Tomohiro Yamazaki et al.

MOLECULAR CELL (2018)

Article Biochemistry & Molecular Biology

A novel long non-coding RNA from NBL2 pericentromeric macrosatellite forms a perinucleolar aggregate structure in colon cancer

Gabrijela Dumbovic et al.

NUCLEIC ACIDS RESEARCH (2018)

Review Physics, Multidisciplinary

Physical principles of intracellular organization via active and passive phase transitions

Joel Berry et al.

REPORTS ON PROGRESS IN PHYSICS (2018)

Article Multidisciplinary Sciences

RNA buffers the phase separation behavior of prion-like RNA binding proteins

Shovamayee Maharana et al.

SCIENCE (2018)

Review Biochemistry & Molecular Biology

Paraspeckles: Where Long Noncoding RNA Meets Phase Separation

Archa H. Fox et al.

TRENDS IN BIOCHEMICAL SCIENCES (2018)

Review Biochemistry & Molecular Biology

Emerging Roles for Intermolecular RNA-RNA Interactions in RNP Assemblies

Briana Van Treeck et al.

Article Biochemistry & Molecular Biology

Liquid Nuclear Condensates Mechanically Sense and Restructure the Genome

Yongdae Shin et al.

Article Polymer Science

50th Anniversary Perspective: Block Polymers-Pure Potential

Christopher M. Bates et al.

MACROMOLECULES (2017)

Article Chemistry, Multidisciplinary

Monomeric Huntingtin Exon 1 Has Similar Overall Structural Features for Wild-Type and Pathological Polyglutamine Lengths

John B. Warner et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

Article Biotechnology & Applied Microbiology

GRID-seq reveals the global RNA-chromatin interactome

Xiao Li et al.

NATURE BIOTECHNOLOGY (2017)

Review Cell Biology

Biomolecular condensates: organizers of cellular biochemistry

Salman F. Banani et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)

Review Multidisciplinary Sciences

Liquid phase condensation in cell physiology and disease

Yongdae Shin et al.

SCIENCE (2017)

Article Biochemistry & Molecular Biology

Unusual semi-extractability as a hallmark of nuclear body-associated architectural noncoding RNAs

Takeshi Chujo et al.

EMBO JOURNAL (2017)

Correction Biochemistry & Molecular Biology

Systematic Mapping of RNA-Chromatin Interactions In Vivo (vol 27, pg 602, 2017)

Bharat Sridhar et al.

CURRENT BIOLOGY (2017)

Review Biochemistry & Molecular Biology

Architectural RNAs (arcRNAs): A class of long noncoding RNAs that function as the scaffold of nuclear bodies

Takeshi Chujo et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2016)

Article Biochemistry & Molecular Biology

Coexisting Liquid Phases Underlie Nucleolar Subcompartments

Marina Feric et al.

Article Cell Biology

Adaptation to stressors by Systemic Protein Amyloidogenesis

Timothy E. Audas et al.

DEVELOPMENTAL CELL (2016)

Article Cell Biology

Structural, super-resolution microscopy analysis of paraspeckle nuclear body organization

Jason A. West et al.

JOURNAL OF CELL BIOLOGY (2016)

Article Biochemistry & Molecular Biology

Unusual Processing Generates SPA LncRNAs that Sequester Multiple RNA Binding Proteins

Huang Wu et al.

MOLECULAR CELL (2016)

Article Biochemistry & Molecular Biology

RNA Controls PolyQ Protein Phase Transitions

Huaiying Zhang et al.

MOLECULAR CELL (2015)

Article Multidisciplinary Sciences

SWI/SNF chromatin-remodeling complexes function in noncoding RNA-dependent assembly of nuclear bodies

Tetsuya Kawaguchi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Multidisciplinary Sciences

RNA transcription modulates phase transition-driven nuclear body assembly

Joel Berry et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Biochemistry & Molecular Biology

The long noncoding RNA Neat1 is required for mammary gland development and lactation

Laura Standaert et al.

Article Medicine, Research & Experimental

Spliceosome integrity is defective in the motor neuron diseases ALS and SMA

Hitomi Tsuiji et al.

EMBO MOLECULAR MEDICINE (2013)

Article Cell Biology

Whole-genome screening identifies proteins localized to distinct nuclear bodies

Ka-wing Fong et al.

JOURNAL OF CELL BIOLOGY (2013)

Article Multidisciplinary Sciences

Unmasking the roles of N- and C-terminal flanking sequences from exon 1 of huntingtin as modulators of polyglutamine aggregation

Scott L. Crick et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Chemistry, Multidisciplinary

Self-assembly of block copolymers

Yiyong Mai et al.

CHEMICAL SOCIETY REVIEWS (2012)

Article Biochemistry & Molecular Biology

Alternative 3′-end processing of long noncoding RNA initiates construction of nuclear paraspeckles

Takao Naganuma et al.

EMBO JOURNAL (2012)

Article Cell Biology

A triple helix stabilizes the 3′ ends of long noncoding RNAs that lack poly(A) tails

Jeremy E. Wilusz et al.

GENES & DEVELOPMENT (2012)

Article Polymer Science

Multicompartment Block Polymer Micelles

Adam O. Moughton et al.

MACROMOLECULES (2012)

Article Multidisciplinary Sciences

Formation of triple-helical structures by the 3′-end sequences of MALAT1 and MENβ noncoding RNAs

Jessica A. Brown et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Multidisciplinary Sciences

Structure of the heterodimer of human NONO and paraspeckle protein component 1 and analysis of its role in subnuclear body formation

Daniel M. Passon et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Biochemistry & Molecular Biology

Cellular toxicity of expanded RNA repeats: focus on RNA foci

Marzena Wojciechowska et al.

HUMAN MOLECULAR GENETICS (2011)

Article Cell Biology

Nucleation of nuclear bodies by RNA

Sergey P. Shevtsov et al.

NATURE CELL BIOLOGY (2011)

Article Neurosciences

Characterizing the RNA targets and position-dependent splicing regulation by TDP-43

James R. Tollervey et al.

NATURE NEUROSCIENCE (2011)

Article Multidisciplinary Sciences

Mechanism of RNA stabilization and translational activation by a pentatricopeptide repeat protein

Jana Prikryl et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Review Cell Biology

Assembly and disassembly of the nucleolus during the cell cycle

Daniele Hernandez-Verdun

NUCLEUS (2011)

Article Biochemistry & Molecular Biology

Modulation of Polyglutamine Conformations and Dimer Formation by the N-Terminus of Huntingtin

Tim E. Williamson et al.

JOURNAL OF MOLECULAR BIOLOGY (2010)

Article Cell Biology

Nuclear Stress Bodies

Giuseppe Biamonti et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)

Article Biochemistry & Molecular Biology

An Architectural Role for a Nuclear Noncoding RNA: NEAT1 RNA Is Essential for the Structure of Paraspeckles

Christine M. Clemson et al.

MOLECULAR CELL (2009)

Article Multidisciplinary Sciences

MENε/β noncoding RNAs are essential for structural integrity of nuclear paraspeckles

Yasnory T. F. Sasaki et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Multidisciplinary Sciences

Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation

Clifford P. Brangwynne et al.

SCIENCE (2009)

Article Chemistry, Multidisciplinary

Temperature triggered self-assembly of polypeptides into multivalent spherical micelles

Matthew R. Dreher et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)

Review Cell Biology

RNA-binding proteins: modular design for efficient function

Bradley M. Lunde et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)

Article Polymer Science

Diblock copolymer micelles in a dilute solution

EB Zhulina et al.

MACROMOLECULES (2005)