Current progress of ferroptosis study in ovarian cancer

Tumors are the leading cause of death all over the world, among which ovarian cancer ranks the third in gynecological malignancies. The current treatment for ovarian cancer is liable to develop chemotherapy resistance and high recurrence rate, in which a new strategy is demanded. Ferroptosis, a newly discovered manner of regulatory cell death, is shown to be induced by massive iron-dependent accumulation of lipid reactive oxygen species. With the in-depth study of ferroptosis, its associated mechanism with various tumors is gradually elucidated, including ovarian tumor, which probably promotes the application of ferroptosis in treating ovarian cancer. To this end, this review will focus on the history and current research progress of ferroptosis, especially its regulation mechanism, and its potential application as a novel treatment strategy for ovarian cancer.

Automated summary

Tumors are the leading cause of death worldwide, with ovarian cancer ranking third among gynecological malignancies. The current treatment for ovarian cancer faces challenges of chemotherapy resistance and high recurrence rate, calling for a new strategy. Ferroptosis, a recently discovered regulatory cell death mechanism, triggered by iron-dependent accumulation of lipid reactive oxygen species, has been investigated in various tumors, including ovarian cancer, and shows potential application in its treatment. This review focuses on the history, current research progress, regulatory mechanism, and potential application of ferroptosis as a novel treatment strategy for ovarian cancer.