Applications of liquid chromatography-mass spectrometry based metabolomics in predictive and personalized medicine

Metabolomics is a fast-developing technique used in biomedical researches focusing on pathological mechanism illustration or novel biomarker development for diseases. The ability of simultaneously quantifying thousands of metabolites in samples makes metabolomics a promising technique in predictive or personalized medicine-oriented researches and applications. Liquid chromatography-mass spectrometry is the most widely employed analytical strategy for metabolomics. In this current mini-review, we provide a brief update on the recent developments and novel applications of LC-MS based metabolomics in the predictive and personalized medicine sector, such as early diagnosis, molecular phenotyping or prognostic evaluation. COVID-19 related metabolomic studies are also summarized. We also discuss the prospects of metabolomics in precision medicine-oriented researches, as well as critical issues that need to be addressed when employing metabolomic strategy in clinical applications.

Automated summary

Metabolomics is a rapidly developing technique with promising applications in disease prediction and personalized medicine. Liquid chromatography-mass spectrometry is the most widely used analytical strategy, and recent studies have demonstrated its novel applications in predictive and personalized medicine, such as early diagnosis and prognostic evaluation. The application of metabolomics in COVID-19 research is also summarized.