The Role of the Thioredoxin System in Brain Diseases

The thioredoxin system, consisting of thioredoxin (Trx), thioredoxin reductase (TrxR), and NADPH, plays a fundamental role in the control of antioxidant defenses, cell proliferation, redox states, and apoptosis. Aberrations in the Trx system may lead to increased oxidative stress toxicity and neurodegenerative processes. This study reviews the role of the Trx system in the pathophysiology and treatment of Alzheimer's, Parkinson's and Huntington's diseases, brain stroke, and multiple sclerosis. Trx system plays an important role in the pathophysiology of those disorders via multiple interactions through oxidative stress, apoptotic, neuro-immune, and pro-survival pathways. Multiple aberrations in Trx and TrxR systems related to other redox systems and their multiple reciprocal relationships with the neurodegenerative, neuro-inflammatory, and neuro-oxidative pathways are here analyzed. Genetic and environmental factors (nutrition, metals, and toxins) may impact the function of the Trx system, thereby contributing to neuropsychiatric disease. Aberrations in the Trx and TrxR systems could be a promising drug target to prevent and treat neurodegenerative, neuro-inflammatory, neuro-oxidative stress processes, and related brain disorders.

Automated summary

The thioredoxin system plays a vital role in various neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's diseases, through its involvement in oxidative stress, apoptotic, neuro-immune, and pro-survival pathways. Numerous aberrations in the system, influenced by genetic and environmental factors, may contribute to the development of these neuropsychiatric disorders. Targeting the thioredoxin system could be a promising approach for the prevention and treatment of neurodegenerative, neuro-inflammatory, and neuro-oxidative stress processes and related brain disorders.