Related references
Note: Only part of the references are listed.
Article
Biochemistry & Molecular Biology
Nikola Capkova et al.
Summary: The study compared the effects of bilirubin and its major photo-oxidation product on neural stem cells, showing that bilirubin exerted dose-dependent cytotoxicity while the photo-oxidation product had a substantial impact on cell morphology and protein redistribution.
Article
Biochemistry & Molecular Biology
Giulia Bortolussi et al.
Summary: Inhibiting bilirubin production shows promise in preventing neurotoxicity in neonatal and adult settings. Deficiency of Bvra was found to prevent lethality and normalize bilirubin levels in adult mice, surpassing Ugt1(-/-) mice. Bvra(-/-)Ugt1(-/-) mice developed normally, with increased iron levels and reduced oxidative status in erythrocytes.
Review
Biochemistry & Molecular Biology
Christopher A. Adin
Summary: Serum free bilirubin concentration has significant effects on morbidity and mortality in major health conditions such as cardiovascular disease, diabetes, and obesity/metabolic syndrome. Challenges in using bilirubin as a therapeutic agent in human patients include poor solubility, complex molecular structure, and concerns about animal-derived sources. However, advancements in drug delivery, biosynthetic strategies, and drug synthesis offer new possibilities for applying bilirubin as a pharmaceutical agent.
Article
Biochemistry & Molecular Biology
Jaromir Petrtyl et al.
Summary: The study revealed dysregulated bilirubin metabolism in NAFLD patients, likely due to increased oxidative stress, with no effect on NAFLD development from major functional variants in the HMOX1 or UGT1A1 gene promoters.
Article
Biochemistry & Molecular Biology
Yang Ho et al.
Summary: This study found that serum bilirubin levels and HO-1 and UGT1A1 gene polymorphisms were associated with cardiovascular disease among patients receiving chronic hemodialysis.
Article
Biochemistry & Molecular Biology
Karl-Heinz Wagner et al.
Summary: Subjects with Gilbert's syndrome show higher levels of antioxidant potential and protein oxidation products, as well as lower levels of apolipoprotein B, hs-C-reactive protein, interleukin 6, and interleukin 1 beta compared to healthy controls. Resting heart rate is also significantly lower in the GS group. Older subjects with GS demonstrate stronger protective effects.
Review
Biochemistry & Molecular Biology
Lovro Ziberna et al.
Summary: This review paper discusses the relationship between obesity and bilirubin, highlighting that obese patients typically have lower serum bilirubin levels as bilirubin is a potent antioxidant molecule that helps alleviate inflammation. The study also proposes potential strategies to increase serum bilirubin levels in obese patients.
