4.7 Article

Quercus acuta Thunb. Suppresses LPS-Induced Neuroinflammation in BV2 Microglial Cells via Regulating MAPK/NF-κB and Nrf2/HO-1 Pathway

Related references

Note: Only part of the references are listed.
Review Clinical Neurology

Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?

Fangda Leng et al.

Summary: Microglial activation and neuroinflammation play important roles in Alzheimer's disease, affecting disease progression and pathologies. Current research focuses on the interplay between neuroinflammation and amyloid and tau pathologies, with a specific interest in modulating microglia as a therapeutic strategy for AD.

NATURE REVIEWS NEUROLOGY (2021)

Review Neurosciences

Microglia in Neuroinflammation and Neurodegeneration: From Understanding to Therapy

Luca Muzio et al.

Summary: Microglia are resident macrophages of the central nervous system, playing a crucial role in immune defense in the brain. They support cell proliferation of neural precursors during brain development and preserve the integrity of neuronal circuits by sculpting synapses in post-natal life. Their functions change after CNS injury, but the precise role in neurological disorders is still not fully understood. There is evidence suggesting that regulating microglia functions could be a potential strategy for future therapies in neurodegenerative disorders such as multiple sclerosis, Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis.

FRONTIERS IN NEUROSCIENCE (2021)

Article Biochemistry & Molecular Biology

Quercus acuta Thunb. (Fagaceae) and Its Component, Isoquercitrin, Inhibit HSV-1 Replication by Suppressing Virus-Induced ROS Production and NF-κB Activation

Buyun Kim et al.

Summary: This study demonstrates that Quercus acuta has antiviral effects against HSV-1 infection, with its main components including chlorogenic acid and isoquercitrin. Through inhibition of ROS expression and NF-kB activity, as well as promotion of IRF3 phosphorylation activity, QA can effectively prevent the replication and spread of HSV-1 virus.

ANTIOXIDANTS (2021)

Review Immunology

Regulation of inflammation by the antioxidant haem oxygenase 1

Nicole K. Campbell et al.

Summary: HO-1, known for its antioxidant properties, has also been shown to have anti-inflammatory effects, making it a potential treatment for chronic inflammatory and autoimmune diseases. Inducing HO-1 has therapeutic potential, but there are challenges to translating this treatment to clinical use.

NATURE REVIEWS IMMUNOLOGY (2021)

Review Integrative & Complementary Medicine

Medicinal Uses, Phytochemistry, and Pharmacological Activities of Quercus Species

Mehdi Taib et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2020)

Review Biochemistry & Molecular Biology

ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease

Dominic S. A. Simpson et al.

ANTIOXIDANTS (2020)

Review Immunology

Toll-like receptors in the pathogenesis of neuroinflammation

V Kumar

JOURNAL OF NEUROIMMUNOLOGY (2019)

Article Biochemistry & Molecular Biology

Phenolic Profile of Grape Canes: Novel Compounds Identified by LC-ESI-LTQ-Orbitrap-MS

Danilo Escobar-Avello et al.

MOLECULES (2019)

Article Integrative & Complementary Medicine

In Vitro and In Vivo Studies on Quercus acuta Thunb. (Fagaceae) Extract: Active Constituents, Serum Uric Acid Suppression, and Xanthine Oxidase Inhibitory Activity

In-Soo Yoon et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2017)

Review Biochemistry & Molecular Biology

NF-kappa B signaling in inflammation

Ting Liu et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2017)

Review Biochemistry & Molecular Biology

Nrf2 signaling pathway: Pivotal roles in inflammation

Syed Minhaj Uddin Ahmed et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2017)

Article Biochemistry & Molecular Biology

Analysis of Flavonoids in Rhamnus davurica and Its Antiproliferative Activities

Guilin Chen et al.

MOLECULES (2016)

Article Multidisciplinary Sciences

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

Eri H. Kobayashi et al.

NATURE COMMUNICATIONS (2016)

Review Clinical Neurology

Neuroinflammation in Alzheimer's disease

Michael T. Heneka et al.

LANCET NEUROLOGY (2015)

Review Neurosciences

Implications of glial nitric oxide in neurodegenerative diseases

Jose Enrique Yuste et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2015)

Review Neurosciences

Neuroinflammation: The role and consequences

Monty Lyman et al.

NEUROSCIENCE RESEARCH (2014)

Review Biochemistry & Molecular Biology

Nrf2:INrf2 (Keap1) signaling in oxidative stress

James W. Kaspar et al.

FREE RADICAL BIOLOGY AND MEDICINE (2009)

Article Biochemistry & Molecular Biology

MAPK signalling pathways as molecular targets for anti-inflammatory therapy - from molecular mechanisms to therapeutic benefits

B Kaminska

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2005)

Article Biochemistry & Molecular Biology

Phosphorylation of RelA/p65 on serine 536 defines an IκBα-independent NF-κB pathway

CY Sasaki et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Geriatrics & Gerontology

Importance of MAPK pathways for microglial pro-inflammatory cytokine IL-1β production

SH Kim et al.

NEUROBIOLOGY OF AGING (2004)

Article Clinical Neurology

Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases

L Minghetti

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2004)

Review Immunology

Nitric oxide in immunity and inflammation

JW Coleman

INTERNATIONAL IMMUNOPHARMACOLOGY (2001)

Article Biochemistry & Molecular Biology

Induction of β-transducin repeat-containing protein by JNK signaling and its role in the activation of NF-κB

VS Speigelman et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)