Journal
JOURNAL OF MEDICAL VIROLOGY
Volume 88, Issue 11, Pages 1837-1843Publisher
WILEY
DOI: 10.1002/jmv.24559
Keywords
digestive system; cell cultures; model organisms
Categories
Funding
- NIH [1R01AI116892]
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Noroviruses constitute a family of ubiquitous and highly efficient human pathogens. In spite of decades of dedicated research, human noroviruses remain a major cause of gastroenteritis and severe diarrheal disease around the world. Recent findings have begun to unravel the complex mechanisms that regulate norovirus pathogenesis and persistent infection, including the important interplay between the virus, the host immune system, and commensal bacteria. Herein, we will summarize recent research developments regarding norovirus cell tropism, the use of M cells, and commensal bacteria to facilitate norovirus infection, and virus, host, and bacterial determinants of persistent norovirus infections. (C) 2016 Wiley Periodicals, Inc.
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