Related references
Note: Only part of the references are listed.
Review
Physiology
Giuseppe Cirino et al.
Summary: This article provides a comprehensive review of the role of hydrogen sulfide (H2S) as an endogenous regulator in various physiological functions. It discusses the regulation, degradation, and elimination pathways of H2S enzymes, as well as the interactions between H2S and other endogenous molecules. Additionally, it outlines the biological targets, signaling pathways, and effects of H2S on cellular bioenergetics and metabolism. The article also reviews the available tools for studying H2S physiology and highlights the wide array of roles H2S plays in the regulation of organ functions.
PHYSIOLOGICAL REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Leonardo A. da Costa Marques et al.
Summary: This study aimed to investigate the effects and mechanisms of action of AP39 on in vitro vascular reactivity of mouse mesenteric artery. The results showed that AP39 and its H2S-releasing moiety promoted vasorelaxation, specifically dependent on NO-cGMP signaling and SKCa channel opening. Furthermore, endogenous H2S seems to be involved in the mechanism of action of AP39, suggesting that mitochondria-targeted H2S donors may provide a new perspective in the treatment of cardiovascular diseases.
Article
Biochemistry & Molecular Biology
Halina Jurkowska et al.
Summary: This study investigated the expression of sulfurtransferases and cystathionine beta-synthase in human leukemia cell lines. The results revealed significant differences in the mRNA and protein levels of these enzymes among different leukemia cells. These findings contribute to understanding the variations in sulfur compound metabolism and provide potential targets for inhibiting leukemic cell proliferation.
Review
Biochemistry & Molecular Biology
Karl-Friedrich Beck et al.
Summary: This article discusses the synthesis and action of hydrogen sulfide (H2S) in glomerular cells, as well as its protective effects on the glomerulus. It also highlights the interaction between H2S and other gasotransmitters.
Article
Biochemistry & Molecular Biology
Olga G. Zatsepina et al.
Summary: This study investigated the role of hydrogen sulfide (H2S) in learning and memory processes by examining the effects of gene deletions in Drosophila melanogaster. The results showed that the deletion of the CBS gene completely blocked short- and long-term memory formation, while the deletion of the CSE gene impaired long-term memory retention. Transcriptome profiling revealed down-regulation of genes involved in learning and memory, reproductive behavior, cognition, and the oxidation-reduction process in strains with CBS deletion, highlighting the importance of H2S production in these vital processes.
Editorial Material
Biochemistry & Molecular Biology
Frederic Bouillaud
Summary: This article examines the consequences of sulfide oxidation by mitochondrial sulfide quinone reductase in mammalian cells. The oxidation of sulfide helps to avoid self-poisoning and has a lower ATP/O-2 ratio compared to other mitochondrial substrates. It increases cellular oxygen consumption and impacts the cellular ATP/ADP ratio.
Article
Biochemistry & Molecular Biology
Jolanta Kowalczyk-Boltuc et al.
Summary: This study investigated the effects of hydrogen sulfide (H2S) and inorganic polysulfides on insulin sensitivity in adipose tissue. The results suggest that polysulfides may normalize insulin sensitivity, at least in the adipose tissue, in obesity/metabolic syndrome.
Review
Biochemistry & Molecular Biology
Tamara Merz et al.
Summary: The discovery of endogenous H2S with cytoprotective properties has led to efforts in developing H2S as a therapeutic agent. H2S's ability to regulate various processes makes it potentially useful in managing critical illnesses. However, current methods of delivering H2S are not feasible for clinical use. Na2S2O3, a clinically approved compound, shows promise in pre-clinical studies for managing critical illnesses. Clinical trials are investigating its potential in myocardial infarction, and it may also be relevant for pre-eclampsia and COVID-19 pneumonia.
Review
Biochemistry & Molecular Biology
Eugenia Piragine et al.
Summary: After its discovery in the central nervous system, the physiological role of H2S has been extensively studied, especially in the control of vascular tone. Natural molecules derived from plants like garlic and rocket have shown slow H2S-releasing properties and potential as tools for hypertension management.
Article
Biochemistry & Molecular Biology
Nazeer Hussain Khan et al.
Summary: This study investigates the role of endogenous hydrogen sulfide (H2S) in the growth of breast cancer. It is found that inhibiting endogenous H2S production can significantly inhibit the growth of breast cancer cells, mediated by a specific signaling pathway. In vivo experiments in mice confirmed this effect without obvious toxicity. These findings reveal the potential therapeutic value of endogenous H2S in breast cancer treatment.
Article
Biochemistry & Molecular Biology
Kelly Ascencao et al.
Summary: The expression of the reverse transsulfuration enzyme cystathionine-beta-synthase (CBS) varies in different types of cancer, and is associated with survival rates. CBS and its product hydrogen sulfide (H2S) play various roles in tumor growth, cell protection, and angiogenesis in high-CBS expressing tumor cells. This article reviews the potential of CBS silencing and pharmacological CBS inhibition as potential cancer therapies, and discusses the identification of biomarkers for future targeted treatments.
Article
Biochemistry & Molecular Biology
Kelly Ascencao et al.
Summary: This study aims to investigate the effect of sequential mutations in colon epithelial cells on the expression of hydrogen sulfide (H2S) producing enzymes. The results show that consecutive mutations result in gradual upregulation of H2S producing enzymes, and when the balance between H2S production and degradation is disrupted, increased H2S generation is observed. This leads to changes in cellular bioenergetics and dedifferentiation, ultimately producing more aggressive colon cancer phenotypes.
Article
Multidisciplinary Sciences
Katalin Erdelyi et al.
Summary: Basal like breast cancer (BLBC) is an aggressive subtype of breast tumors with high Cys demand and reprogrammed Cys metabolism. CBS overexpression promotes tumor progression in BLBC, while CBS silencing makes BLBC cells more vulnerable to oxidative stress and CySSCy deprivation, leading to ferroptosis. This study suggests that persulfide-producing pathways are potential therapeutic targets for BLBC.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Joshua J. Scammahorn et al.
Summary: Hydrogen sulfide (H2S) serves as a crucial gaseous signaling molecule in physiological and pathophysiological processes, maintaining redox balance and promoting antioxidant mechanisms. Depletion of H2S is implicated in various diseases, leading to research interest in therapeutic interventions.
Article
Biochemistry & Molecular Biology
Dario Pacitti et al.
Summary: Hydrogen sulfide plays important roles in lung diseases, exerting anti-inflammatory and antiviral effects, improving cell metabolism, and protecting against oxidative stress. However, dysregulation of endogenous H2S synthesis may contribute to the development of respiratory diseases, and persulfidation of H2S is reduced with aging.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Marta Kaczor-Kaminska et al.
Summary: This paper provides information on the activity and expression levels of three sulfurtransferases in various cell lines and their correlation with cellular antioxidant capacity. By analyzing the genetic variation of sulfurtransferases, the study reveals a large number of polymorphisms. Despite challenges, understanding sulfurtransferases could enhance disease comprehension and potentially lead to new treatment approaches.
Article
Biochemistry & Molecular Biology
Syed F. Hashmi et al.
Summary: Chronic administration of hydrogen sulphide donor (sodium hydrosulphide) improved renal ischemia-reperfusion injury in hypertensive rats, reducing blood pressure and oxidative stress markers while decreasing levels of ICAM-1 and NF-kB. The treatment with NaHS showed improvement in renal functional parameters and tubular morphology, indicating a potential antioxidant and anti-inflammatory mechanism.
Review
Biochemistry & Molecular Biology
Honami Echizen et al.
Summary: Hydrogen sulfide and its oxidation products play important roles in biological processes, with sulfane sulfur compounds attracting increasing interest for their physiological and pathophysiological roles. Traditional cyanolysis can be used to detect sulfane sulfur compounds, while recent studies have developed various chemical techniques for detection, isolation, and bioimaging of these compounds in biological samples.
Article
Biochemistry & Molecular Biology
Smriti Juriasingani et al.
Summary: Cold preservation is the standard care for renal grafts, but research on alternatives like perfusion at higher temperatures and supplementing preservation solutions with hydrogen sulfide (H2S) has shown promising results. This study found that subnormothermic perfusion at 21 degrees C with H2S-supplemented blood improved renal graft outcomes, as indicated by increased urine output, reduced apoptotic injury, and changes in pro-survival gene expression patterns. Further research is needed for the clinical translation of this approach.
Review
Biochemistry & Molecular Biology
Kyle B. LaPenna et al.
Summary: Hydrogen sulfide (H2S) is an endogenous gaseous signaling molecule that plays a critical role in cardiac and vascular biology by regulating vascular tone, oxidant defenses, and exerting cytoprotective effects. Recent studies have shown that H2S modulates various components of metabolic syndrome and exhibits cardioprotective signaling in heart failure.
Review
Geriatrics & Gerontology
Dunja Petrovic et al.
Summary: Protein persulfidation plays an important role in physiology and pathophysiology, but its study is hampered by its instability and chemical reactivity. Persulfide levels are crucial for defense against oxidative damage, but decrease with age, leading to increased protein susceptibility to oxidation. Dysregulation of persulfidation is observed in various neurodegenerative diseases, suggesting potential for targeted drug design through further research in this area.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Mark R. Hellmich et al.
Summary: The upregulation of CBS in cancer cells has been identified as a tumor-promoting factor, leading to the synthesis of a novel CBS-targeting prodrug YD0251 with higher efficacy in inhibiting tumor growth compared to the prototypical CBS inhibitor AOAA. The prodrug was successful in suppressing tumor growth in vivo with low toxicity, and a potential plasma marker for CBS-expressing tumors was identified for potential future theranostic applications to match CBS inhibitor therapy with high-CBS expressors.
Review
Biochemistry & Molecular Biology
Hideo Kimura
Summary: Initially considered a toxic gas, further research has shown that H2S has physiological roles and can act as a signaling molecule, working in synergy with NO to relax vascular smooth muscle. H2Sn, produced by 3MST, regulate the activity of ion channels and enzymes, and even affect tumor growth.
Article
Biochemistry & Molecular Biology
Hideo Kimura
NEUROCHEMISTRY INTERNATIONAL
(2019)
Review
Pharmacology & Pharmacy
Bindu D. Paul et al.
BIOCHEMICAL PHARMACOLOGY
(2018)
Review
Pharmacology & Pharmacy
Csaba Szabo et al.
PHARMACOLOGICAL REVIEWS
(2017)
Article
Biochemistry & Molecular Biology
Bartosz Szczesny et al.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2014)
Article
Biochemistry & Molecular Biology
Sophie Le Trionnaire et al.
Article
Multidisciplinary Sciences
Csaba Szabo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2013)
