4.7 Article

Bio-Multifunctional Sponges Containing Alginate/Chitosan/Sargassum Polysaccharides Promote the Healing of Full-Thickness Wounds

Journal

BIOMOLECULES
Volume 12, Issue 11, Pages -

Publisher

MDPI
DOI: 10.3390/biom12111601

Keywords

Sargassum pallidum polysaccharides; bio-multifunctional; composite sponges; wound healing; alginate; chitosan

Funding

  1. Start-up Fund of Guangdong Medical University [GDMUB2021005, GDMUB2022032, 2017C8A]
  2. Special Science and Technology Innovation Project of Guangdong Province, China [2019A01005, 2019A03023]

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This study created bio-multifunctional composite sponges with potent hemostatic, antibacterial, anti-inflammatory, and angiogenesis features for treating full-thickness wounds.
Creation of bio-multifunctional wound dressings with potent hemostatic, antibacterial, anti-inflammatory, and angiogenesis features for bolstering the healing of full-thickness wounds is sought after for clinical applications. We created bio-multifunctional composite sponges by coupling alginate and chitosan with Sargassum pallidum polysaccharides through electrostatic interactions, calcium ion (Ca2+) crosslinking, and lyophilization. Alginate/chitosan (AC) sponges with different concentrations of Sargassum pallidum polysaccharides were obtained and termed AC, ACS-1%, ACS-2.5%, and ACS-5%. ACS-1% and ACS-2.5% sponges exhibited uniform porosity, high water vapor transmission rate, high water absorption, as well as good hemostatic and antibacterial abilities. ACS-2.5% sponges facilitated wound closure and promoted angiogenesis and re-epithelialization in the dermis. These data suggest that ACS sponges containing a certain amount of Sargassum pallidum polysaccharides could be employed for treatment of full-thickness skin wounds.

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