Journal
BIOMOLECULES
Volume 12, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/biom12081152
Keywords
ER-PM junctions; STIM; Orai1; phospholipids; calcium signaling; SOCE
Categories
Funding
- NIDCR-DIR, NIH [Z01-DE00438-33]
Ask authors/readers for more resources
ER-PM junctions, formed by the endoplasmic reticulum and plasma membrane, play a crucial role in assembling calcium signaling complexes. The formation and stability of these junctions rely on the enrichment of specific proteins, which contribute to junctional stability and regulate the lipid levels of ER and plasma membranes.
ER-PM junctions are membrane contact sites formed by the endoplasmic reticulum (ER) and plasma membrane (PM) in close apposition together. The formation and stability of these junctions are dependent on constitutive and dynamic enrichment of proteins, which either contribute to junctional stability or modulate the lipid levels of both ER and plasma membranes. The ER-PM junctions have come under much scrutiny recently as they serve as hubs for assembling the Ca2+ signaling complexes. This review summarizes: (1) key findings that underlie the abilities of STIM proteins to accumulate in ER-PM junctions; (2) the modulation of Orai/STIM complexes by other components found within the same junction; and (3) how Orai1 channel activation is coordinated and coupled with downstream signaling pathways.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available