Journal
BIOMOLECULES
Volume 12, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/biom12101359
Keywords
acute myeloid leukemia; biomarkers; TRH expression; prognosis
Categories
Funding
- Guangdong Basic and Applied Basic Research Foundation [2021A1515110012]
- Shanghai Rising-Star Program [22QA1405600]
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Using single-cell RNA sequencing technology, the study revealed the prognostic value of thyrotropin-releasing hormone (TRH) as a biomarker in RUNX1-RUNX1T1 AML. TRH expression was found to be associated with age and genetic mutations, and it could improve the risk stratification system in AML.
Acute myeloid leukemia (AML) is a biologically and genetically heterogeneous hematological malignance with an unsatisfactory risk stratification system. Recently, through the novel single-cell RNA sequencing technology, we revealed heterogeneous leukemia myeloblasts in RUNX1-RUNX1T1 AML. Thyrotropin-releasing hormone (TRH), as biomarkers of CD34(+)CD117(bri) myeloblasts, were found to be prognostic in RUNX1-RUNX1T1 AML. However, the clinical and genetic features of TRH in AML patients are poorly understood. Here, with data from TCGA AML, TRH was found to be downregulated in patients older than 60 years old, with DNMT3A and NPM1 mutations, while overexpressed in patients with KIT mutations. This was further validated in three other cohorts of primary AML including Beat AML (n = 223), GSE6891 (n = 461), and GSE17855 (n = 237). Furthermore, we demonstrated that the expression of TRH in AML could be used to improve the ELN 2017 risk stratification system. In conclusion, our preliminary analysis revealed that TRH, a novel biomarker for AML patients, could be used to evaluate the survival of AML.
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