4.7 Article

The Deletion of US3 Gene of Pseudorabies Virus (PRV) ΔgE/TK Strain Induces Increased Immunogenicity in Mice

Related references

Note: Only part of the references are listed.
Review Hematology

Intratumoral cancer immunotherapy exploiting anti-viral immunity

Norimitsu Kadowaki

Summary: Immunotherapy has become the mainstream of cancer therapies, but it is only effective for a limited proportion of patients. Intratumoral immunotherapy, which triggers innate immunity at the tumor site, is a promising strategy. Many preclinical and clinical trials have shown significant antitumor effects in mice using this approach.

JOURNAL OF CLINICAL AND EXPERIMENTAL HEMATOPATHOLOGY (2022)

Article Infectious Diseases

Emergence of a novel pathogenic recombinant virus from Bartha vaccine and variant pseudorabies virus in China

Zongyi Bo et al.

Summary: Two PRV variants, named JSY7 and JSY13 strains, were isolated from a Bartha-K61-vaccinated swine farm. These variants showed different cytopathic effects and plaque sizes, but had the same Aspartate insertions in the gE protein. Genomic analysis clustered JSY7 and JSY13 strains in the same clade with other PRV isolates in China. The study also revealed evidence of genomic recombination between the JSY13 strain and the Bartha and JSY7 strains, highlighting the importance of this process in PRV evolution and virulence.

TRANSBOUNDARY AND EMERGING DISEASES (2021)

Review Virology

The Role of Tissue Resident Memory CD4 T Cells in Herpes Simplex Viral and HIV Infection

Thomas R. O'Neil et al.

Summary: CD4(+) TRM are more mobile than CD8(+) TRM, usually localized deeper within the dermis/lamina propria and yet may exhibit synergy with CD8(+) TRM in disease control.

VIRUSES-BASEL (2021)

Review Microbiology

Evasion of I Interferon-Mediated Innate Immunity by Pseudorabies Virus

Rui Zhang et al.

Summary: This review highlights the importance of IFN-I mediated innate immunity in defense against viral infection, focusing on the strategies employed by the alphaherpesvirus Pseudorabies virus (PRV) to counteract IFN-I mediated immunity, particularly through inhibition of IFN-I induced gene transcription via the JAK-STAT pathway. Knowledge gained from PRV contributes to understanding alphaherpesviral immune evasion mechanisms and aids in vaccine development for PRV control.

FRONTIERS IN MICROBIOLOGY (2021)

Article Microbiology

Pseudorabies Virus US3 Protein Inhibits IFN-β Production by Interacting With IRF3 to Block Its Activation

Jingying Xie et al.

Summary: The US3 protein of pseudorabies virus has been identified as a crucial viral factor that represses interferon beta expression by targeting interferon regulatory factor 3. This study reveals a novel strategy used by PRV to inhibit IFN-beta production and evade host innate immunity.

FRONTIERS IN MICROBIOLOGY (2021)

Article Veterinary Sciences

Recombinant pseudorabies virus with gI/gE deletion generated by overlapping polymerase chain reaction and homologous recombination technology induces protection against the PRV variant PRV-GD2013

Wenhui Li et al.

Summary: This study constructed a novel recombinant vaccine strain with gI/gE deletion (PRV-GD2013-Delta gI/gE) and demonstrated that the recombinant virus was significantly attenuated in mice and avirulent in piglets. High doses of PRV-GD2013-Delta gI/gE provided complete protection against PRV-GD2013 infection in piglets.

BMC VETERINARY RESEARCH (2021)

Article Veterinary Sciences

Detection of pseudorabies virus antibody in swine serum and oral fluid specimens using a recombinant gE glycoprotein dual-matrix indirect ELISA

Ting-Yu Cheng et al.

Summary: A dual-matrix indirect IgG gE ELISA was developed and showed high sensitivity in detecting PRV virus in oral fluid samples, supporting the concept of PRV surveillance based on oral fluid samples tested by an indirect gE ELISA.

JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION (2021)

Article Veterinary Sciences

Establishment of inflammatory model induced by Pseudorabies virus infection in mice

Chun-Zhi Ren et al.

Summary: The study established an inflammatory model induced by PRV infection in mice, with 10(2) TCID50 PRV considered as the optimal concentration for model establishment. PRV infection caused increased immune organ indices, ROS and NO levels, inflammatory mediators, and oxidative stress.

JOURNAL OF VETERINARY SCIENCE (2021)

Article Medicine, Research & Experimental

Tissue-resident T cell derived cytokines eliminate herpes simplex virus-2-infected cells

Pavitra Roychoudhury et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Article Biochemical Research Methods

Construction and immunogenicity of a gE/gI/TK-deleted PRV based on porcine pseudorabies virus variant

Yu Zhao et al.

MOLECULAR AND CELLULAR PROBES (2020)

Review Microbiology

The Neuropathic Itch Caused by Pseudorabies Virus

Kathlyn Laval et al.

PATHOGENS (2020)

Article Veterinary Sciences

Pseudorabies virus (PRV) strain with defects in gE, gC, and TK genes protects piglets against an emerging PRV variant

Jinxin Lin et al.

JOURNAL OF VETERINARY MEDICAL SCIENCE (2020)

Article Microbiology

Vaccines against pseudorabies virus (PrV)

C. M. Freuling et al.

VETERINARY MICROBIOLOGY (2017)

Review Immunology

An Overview of Live Attenuated Recombinant Pseudorabies Viruses for Use as Novel Vaccines

Bo Dong et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2014)

Article Immunology

Comparing Effects of BK Virus Agnoprotein and Herpes Simplex-1 ICP47 on MHC-I and MHC-II Expression

Michela Cioni et al.

CLINICAL & DEVELOPMENTAL IMMUNOLOGY (2013)

Article Biochemistry & Molecular Biology

Human cytomegalovirus US3 modulates destruction of MHC class I molecules

Vanessa M. Noriega et al.

MOLECULAR IMMUNOLOGY (2012)

Review Virology

Pseudorabies virus in wild swine: a global perspective

T. Mueller et al.

ARCHIVES OF VIROLOGY (2011)

Article Biochemistry & Molecular Biology

Human cytomegalovirus: Host immune modulation by the viral US3 gene

Ziqi Liu et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2009)

Review Microbiology

Molecular biololgy of pseudorabies virus: Impact on neurovirology and veterinary medicine

LE Pomeranz et al.

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2005)

Article Biochemical Research Methods

Expression of pseudorabies virus gE epitopes in Pichia pastoris and its utilization in an indirect PRV gE-ELISA

JQ Ao et al.

JOURNAL OF VIROLOGICAL METHODS (2003)