A sustained release of alendronate from an injectable tetra-PEG hydrogel for efficient bone repair

Article Engineering, Biomedical

Protein-spatiotemporal partition releasing gradient porous scaffolds and anti-inflammatory and antioxidant regulation remodel tissue engineered anisotropic meniscus

Bingbing Xu et al.

Summary: This study successfully prepared a versatile meniscus composite scaffold with heterogeneous bionic structures through the regulation of microenvironment, combining various techniques.

BIOACTIVE MATERIALS (2023)

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Article Chemistry, Applied

Robust, anti-freezing and conductive bonding of chitosan-based double-network hydrogels for stable-performance flexible electronic

Yanyu Yang et al.

Summary: In this study, robust and anti-freezing hydrogel-substrate combinations were successfully constructed by enhancing the adhesion between hydrogels and substrates through a unique linking method. The combinations demonstrated high interfacial toughness even at low temperatures, making them suitable for utilization as multi-model flexible sensors. This work provides a platform for the construction and emerging applications of robust, anti-freezing, and stable-performance hydrogel-based systems.

CARBOHYDRATE POLYMERS (2022)

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Review Biotechnology & Applied Microbiology

Scaffold-Based Tissue Engineering Strategies for Osteochondral Repair

Jiang-Nan Fu et al.

Summary: This article reviews the advances in osteochondral tissue engineering and discusses various strategies including scaffold design, material types, fabrication techniques, and functional properties. Although there are still challenges and difficulties, research in this field is of great importance for repairing OC defects.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Article Engineering, Biomedical

High efficacy of tetra-PEG hydrogel sealants for sutureless dural closure

Tengjiao Zhu et al.

Summary: A tetra-PEG-based hydrogel sealant has been developed for sutureless dural closure during surgery, which can instantly adhere to irregular tissue surfaces even in a liquid environment and effectively prevent intraoperative cerebrospinal fluid leakage.

BIOACTIVE MATERIALS (2022)

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Article Engineering, Biomedical

Facile fabrication of a biocompatible composite gel with sustained release of aspirin for bone regeneration

Yunfan Zhang et al.

Summary: In this study, a semi-interpenetrating network composite gel was prepared to fulfill the mechanical and cell compatibility requirements of hydrogels. The gel successfully encapsulated ASA via electrostatic interactions and achieved sustained release, promoting stem cell proliferation and differentiation. In vivo studies confirmed the potential of this gel in bone tissue engineering.

BIOACTIVE MATERIALS (2022)

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Review Biotechnology & Applied Microbiology

Graphene and its Derivatives for Bone Tissue Engineering: In Vitro and In Vivo Evaluation of Graphene-Based Scaffolds, Membranes and Coatings

Junyao Cheng et al.

Summary: The article provides an overview of the promising properties of graphene and its derivatives in bone tissue engineering. Analyses of graphene-based materials in bone regenerative medicine are discussed based on bone regeneration processes, highlighting their applications as scaffolds, membranes, and coatings. The advantages, challenges, and future prospects of using these materials in bone regenerative medicine are also addressed.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Review Biotechnology & Applied Microbiology

Hydrogel-Based Biomaterials Engineered from Natural-Derived Polysaccharides and Proteins for Hemostasis and Wound Healing

Junyao Cheng et al.

Summary: Hydrogel-based biomaterials, especially those derived from natural polysaccharides and proteins, have shown promising potential in hemostasis due to their biocompatibility, degradability, injectability, and ability to promote coagulation, wound healing, and anti-infection. However, there are still challenges to be overcome for the translation of laboratory research into clinical practice.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Article Nanoscience & Nanotechnology

Mussel-Inspired Bisphosphonated Injectable Nanocomposite Hydrogels with Adhesive, Self-Healing, and Osteogenic Properties for Bone Regeneration

Bo Wang et al.

Summary: Injectable hydrogels mimicking the natural extracellular matrix have advantages such as microinvasive implantation and complex defect repair, but current options for bone repair lack tissue adhesion, self-healing, and osteogenic activity. A new strategy involving mussel-inspired bisphosphonated injectable nanocomposite hydrogels with adhesive, self-healing, and osteogenic properties has been developed, showing excellent biocompatibility and promoting cell viability, proliferation, migration, and osteogenesis differentiation. The hydrogels, dually cross-linked, also demonstrate potential for bone regeneration with the successful healing of a rat cranial defect.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Engineering, Biomedical

Simultaneous incorporation of PTH(1-34) and nano-hydroxyapatite into Chitosan/Alginate Hydrogels for efficient bone regeneration

Zhiyuan Zou et al.

Summary: The use of hydrogels containing PTH and nHAP can promote cranial bone regeneration by enhancing the expression of osteogenic-related proteins and facilitating osteogenic differentiation of BMSCs through the Notch signaling pathway. Implantation of the hydrogel into a rat cranial defect model showed efficient bone regeneration compared to using the hydrogel alone or nHAP alone, indicating a promising therapeutic effect of combining nHAP and PTH for bone regeneration.

BIOACTIVE MATERIALS (2021)

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Review Biochemistry & Molecular Biology

The application of hyaluronic acid in bone regeneration

Peisong Zhai et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Bisphosphonates-much more than only drugs for bone diseases

Anna Kuznik et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

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Editorial Material Chemistry, Multidisciplinary

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The Delivery of RNA-Interference Therapies Based on Engineered Hydrogels for Bone Tissue Regeneration

Tingting Yu et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

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Advances of Naturally Derived and Synthetic Hydrogels for Intervertebral Disk Regeneration

Guoke Tang et al.

Frontiers in Bioengineering and Biotechnology (2020)

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Review Biotechnology & Applied Microbiology

Recent Advances of Chitosan-Based Injectable Hydrogels for Bone and Dental Tissue Regeneration

Guoke Tang et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

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Biocompatible Injectable Magnetic Hydrogel Formed by Dynamic Coordination Network

Liyang Shi et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Biomimetic Nanosilica-Collagen Scaffolds for In Situ Bone Regeneration: Toward a Cell-Free, One-Step Surgery

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Article Multidisciplinary Sciences

Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice

Linda Vi et al.

NATURE COMMUNICATIONS (2018)

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Review Engineering, Biomedical

Bone grafts and biomaterials substitutes for bone defect repair: A review

Wenhao Wang et al.

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Self-Healing Silk Fibroin-Based Hydrogel for Bone Regeneration: Dynamic Metal-Ligand Self-Assembly Approach

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Article Chemistry, Multidisciplinary

Self-Assembled Injectable Nanocomposite Hydrogels Stabilized by Bisphosphonate-Magnesium (Mg2+) Coordination Regulates the Differentiation of Encapsulated Stem Cells via Dual Crosslinking

Kunyu Zhang et al.

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Chondroitin Sulfate-Based Biomineralizing Surface Hydrogels for Bone Tissue Engineering

Hwan D. Kim et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

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Article Medicine, Research & Experimental

Estrogen enhances the bone regeneration potential of periodontal ligament stem cells derived from osteoporotic rats and seeded on nano-hydroxyapatite/collagen/poly(L-lactide)

Ling-Ling E et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2016)

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Article Cell & Tissue Engineering

Small Molecule Inhibition of Transforming Growth Factor Beta Signaling Enables the Endogenous Regenerative Potential of the Mammalian Calvarium

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Small molecules and their controlled release that induce the osteogenic/chondrogenic commitment of stem cells

Yingjun Wang et al.

BIOTECHNOLOGY ADVANCES (2015)

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Article Cell Biology

Crucial role of Notch signaling in osteogenic differentiation of periodontal ligament stem cells in osteoporotic rats

Ying Li et al.

CELL BIOLOGY INTERNATIONAL (2014)

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BMC MEDICINE (2011)

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The effect of the local delivery of alendronate on human adipose-derived stem cell-based bone regeneration

Chau-Zen Wang et al.

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In-vitro osteogenesis of synovium stem cells induced by controlled release of bisphosphate additives from microspherical mesoporous silica composite

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OSTEOPOROSIS INTERNATIONAL (2007)

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NATURE BIOTECHNOLOGY (2000)

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A sustained release of alendronate from an injectable tetra-PEG hydrogel for efficient bone repair

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