Journal
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fbioe.2022.1023032
Keywords
titanium; silicon nitride; corrosion resistance; osteogenesis; angiogenesis
Funding
- Zhejiang Provincial Science and Technology Projects for Public Welfare [LY21H180006, LGF21H140004]
- National Natural Science Foundation of China [82171004, 82071170, 81870810]
- Key Technological Innovation Projects of Wenzhou [ZY2019009]
- Wenzhou Medical University Basic Scientific Research Operating Expenses [KYYW201905]
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Titanium (Ti) implants are commonly used for tooth loss treatment due to their excellent biocompatibility and mechanical properties. However, improving the biological properties of Ti implants to enhance osteointegration remains a challenge. Micro-arc oxidation (MAO) has been proposed as a surface modification technique to improve the comprehensive properties of Ti by forming a protective oxide layer.
Titanium (Ti) implants have been widely used for the treatment of tooth loss due to their excellent biocompatibility and mechanical properties. However, modifying the biological properties of these implants to increase osteointegration remains a research challenge. Additionally, the continuous release of various metal ions in the oral microenvironment due to fluid corrosion can also lead to implant failure. Therefore, simultaneously improving the bioactivity and corrosion resistance of Ti-based materials is an urgent need. In recent decades, micro-arc oxidation (MAO) has been proposed as a surface modification technology to form a surface protective oxide layer and improve the comprehensive properties of Ti. The present study doped nano silicon nitride (Si3N4) particles into the Ti surface by MAO treatment to improve its corrosion resistance and provide excellent osteoinduction by enhancing alkaline phosphatase activity and osteogenic-related gene expression. In addition, due to the presence of silicon, the Si3N4-doped materials showed excellent angiogenesis properties, including the promotion of cell migration and tubule formation, which play essential roles in early recovery after implantation.
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