Journal
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fbioe.2022.1002006
Keywords
NIR-II photoacoustic imaging; small molecule dye; phototheranostics; combination therapy; tumor imaging
Funding
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province
- Natural Science Foundation of Jiangsu University
- Natural Science Foundation of NJUPT
- Research startup fund of NJUPT
- Synergetic Innovation Center for Organic Electronics and Information Displays
- [61905122]
- [22174070]
- [BK20190735]
- [21KJB150022]
- [NY221088]
- [NY220149]
- [NY219006]
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This minireview summarizes the recent advances in small molecule dyes-based nanotheranostics for NIR-II PA imaging and cancer therapy. It introduces NIR-II PA imaging-guided phototherapy and reviews phototherapy-based combination therapeutic systems. The conclusion and perspectives of this field are also discussed.
Photoacoustic (PA) imaging in the second near-infrared (NIR-II) window has gained more and more attention in recent years and showed great potential in the field of bioimaging. Until now, numerous materials have been developed as contrast agents for NIR-II PA imaging. Among them, small molecule dyes hold unique advantages such as definite structures and capability of fast clearance from body. By virtue of these advantages, small molecule dyes-constructed nanoparticles have relatively small size and show promise in the clinical translation. Thus, in this minireview, we summarize recent advances in small molecule dyes-based nanotheranostics for NIR-II PA imaging and cancer therapy. Studies about NIR-II PA imaging-guided phototherapy are first introduced. Then, NIR-II PA imaging-guided phototherapy-based combination therapeutic systems are reviewed. Finally, the conclusion and perspectives of this field are summarized and discussed.
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