☆ 4.7 Review

Lipid-mRNA nanoparticles landscape for cancer therapy

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

Related references

Note: Only part of the references are listed.

Article Chemistry, Multidisciplinary

Discovery of a Novel Amino Lipid That Improves Lipid Nanoparticle Performance through Specific Interactions with mRNA

Mark Cornebise et al.

Summary: Lipid nanoparticles (LNPs) efficiently deliver messenger RNA systemically due to their composition and architecture. Interactions between components in self-assembly establish stable equilibrium. A new squaramide lipid with specific interactions with mRNA enhances particle stability and efficiency.

ADVANCED FUNCTIONAL MATERIALS (2022)

Add to Collection

Article Chemistry, Medicinal

The nano delivery systems and applications of mRNA

Mingyuan Li et al.

Summary: The current COVID-19 epidemic has accelerated the application of mRNA technology, highlighting challenges in overcoming mRNA instability in human physiological environments. Research has also shown that mRNA has potential applications beyond COVID-19 vaccines, such as in treating other diseases and genetic disorders.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Orthogonal Design of Experiments for Optimization of Lipid Nanoparticles for mRNA Engineering of CAR T Cells

Margaret M. Billingsley et al.

Summary: Viral engineered chimeric antigen receptor (CAR) T cell therapies are potent cancer immunotherapies, but their permanent CAR expression can lead to severe adverse effects. Nonviral messenger RNA (mRNA) CAR T cells are being explored as a safer alternative, and this study demonstrates the improved mRNA delivery to T cells with low cytotoxicity using a new ionizable lipid nanoparticle (LNP) formulation (B10). Compared to electroporation, B10 LNPs induce similar CAR expression with reduced cytotoxicity and potent cancer cell killing.

NANO LETTERS (2022)

Add to Collection

Article Oncology

Intravenous Delivery of RNA Encoding Anti-PD-1 Human Monoclonal Antibody for Treating Intestinal Cancer

Lipei Wu et al.

Summary: This study demonstrates the potential of using lipid nanoparticle (LNP)-encapsulated in vitro transcription (IVT) mRNA to express full-size monoclonal antibodies (mAbs) for cancer treatment. The mRNA encoding Pembrolizumab, a commercial anti-PD-1 mAb, was designed and optimized for high expression levels. Delivery of the mRNA-LNPs resulted in sustained serum Pembrolizumab levels and enhanced drug exposure compared to direct injection of Pembrolizumab. Chronic treatment with LNP-encapsulated Pembrolizumab mRNA effectively inhibited tumor growth and improved animal survival. This alternative approach has the potential to overcome the limitations of traditional protein-based therapies.

JOURNAL OF CANCER (2022)

Add to Collection

Article Pharmacology & Pharmacy

Co-Delivery of p53 Restored and E7 Targeted Nucleic Acids by Poly (Beta-Amino Ester) Complex Nanoparticles for the Treatment of HPV Related Cervical Lesions

Jinfeng Xiong et al.

Summary: Restoring p53 expression and inactivating HPV oncoproteins are crucial for blocking the development of cervical cancer. Our study successfully restored p53 expression and inactivated HPV using nano drugs based on nucleic acid delivery, providing potential applications in the treatment of CIN and cervical cancer.

FRONTIERS IN PHARMACOLOGY (2022)

Add to Collection

Article Multidisciplinary Sciences

Thermostable ionizable lipid-like nanoparticle (iLAND) for RNAi treatment of hyperlipidemia

Bo Hu et al.

Summary: A series of ionizable lipid-like materials were designed to develop a thermostable siRNA delivery system. The optimized formulation showed dose and time dual-dependent gene silencing and effectively reduced serum cholesterol and triglyceride levels. This research holds significant value for the treatment of hyperlipidemia and prevention of metabolic diseases.

SCIENCE ADVANCES (2022)

Add to Collection

Article Polymer Science

Effective mRNA Protection by Poly(l-ornithine) Synergizes with Endosomal Escape Functionality of a Charge-Conversion Polymer toward Maximizing mRNA Introduction Efficiency

Anjaneyulu Dirisala et al.

Summary: This study integrates the protective effect against nucleases and the endosomal escape capability into a single polyplex by fine-tuning the catiomer chemical structure and incorporating the endosomal escape modality for efficient mRNA delivery. The methylene spacer length on the catiomer side chain significantly affects the nuclease stability of the polyplex, and introducing a charge-conversion polymer can improve endosomal escape efficiency by approximately 80-fold in cultured cells. The system synergizes PLO's protective effect against nucleases and CCP's endosomal escape capability, leading to enhanced protein expression efficiency from mRNA delivery.

MACROMOLECULAR RAPID COMMUNICATIONS (2022)

Add to Collection

Article Nanoscience & Nanotechnology

Enhancing CRISPR/Cas gene editing through modulating cellular mechanical properties for cancer therapy

Di Zhang et al.

Summary: Modulating the mechanical properties of tumor cells enhances gene editing and inhibits tumor growth by using dendrimer lipid nanoparticles for PD-L1 gene editing and knocking out FAK.

NATURE NANOTECHNOLOGY (2022)

Add to Collection

Article Engineering, Biomedical

Ionizable lipid-assisted efficient hepatic delivery of gene editing elements for oncotherapy

Chunhui Li et al.

Summary: In this study, an ionizable lipid nanoparticle based gene editing system was developed, which demonstrated efficient gene editing both in vitro and in vivo. The system exhibited excellent nanostructure and stability, and showed promising results in tumor treatment.

BIOACTIVE MATERIALS (2022)

Add to Collection

Review Medicine, Research & Experimental

Lipid-Nanoparticle-Based Delivery of CRISPR/Cas9 Genome-Editing Components

Pardis Kazemian et al.

Summary: Gene editing mediated by CRISPR/Cas9 systems is a promising therapeutic option for genetic diseases and cancers. Lipid nanoparticles (LNPs), due to their low immunogenicity and flexibility, have emerged as an attractive nonviral delivery platform for CRISPR-mediated genome editing. The development of new, safe, and optimized LNP formulations has addressed the challenges in CRISPR delivery.

MOLECULAR PHARMACEUTICS (2022)

Add to Collection

Article Biotechnology & Applied Microbiology

mRNA-LNP vaccines tuned for systemic immunization induce strong antitumor immunity by engaging splenic immune cells

Sanne Bevers et al.

Summary: mRNA vaccines have shown high efficacy against SARS-CoV-2, attributed to lipid-based nanoparticles (LNPs) that enable efficient mRNA expression and adjuvant properties. Effective cancer vaccines necessitate long-lived, qualitative CD8 T cell responses. By optimizing LNP composition, researchers achieved high-magnitude tumor-specific CD8 T cell responses. Unexpectedly, they discovered a role of B cells in stimulating the vaccine-elicited CD8 T cell response. Optimized LNPs showed favorable biodistribution profiles in non-human primates and did not cause histopathological changes, calling for further evaluation in clinical studies.

MOLECULAR THERAPY (2022)

Add to Collection

Article Medicine, Research & Experimental

Comparative effectiveness of mRNA-1273 and BNT162b2 against symptomatic SARS-CoV-2 infection

Arjun Puranik et al.

Summary: The mRNA-1273 and BNT162b2 vaccines provide strong protection against symptomatic SARS-CoV-2 infection. However, their effectiveness was reduced during July-September and mRNA-1273 had a lower risk of breakthrough infection compared to BNT162b2.

MED (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Genome-Editing-Mediated Restructuring of Tumor Immune Microenvironment for Prevention of Metastasis

Dongyoon Kim et al.

Summary: The use of metal-lipid hybrid nanoparticles for TGF-beta gene editing can restructure the tumor microenvironment to an immune activated state, leading to potential immunotherapy benefits. The combination of TGF-β gene editing and phototherapy shows promise in preventing tumor recurrence and metastasis.

ACS NANO (2021)

Add to Collection

Article Engineering, Biomedical

Adjuvant-pulsed mRNA vaccine nanoparticle for immunoprophylactic and therapeutic tumor suppression in mice

Mohammad Ariful Islam et al.

Summary: The study demonstrated that using mRNA vaccine nanoparticles with C16-R848 adjuvant can effectively induce anti-tumor immune response, increase the number of OVA-specific CD8(+) T cells, and significantly inhibit tumor growth.

BIOMATERIALS (2021)

Add to Collection

Editorial Material Chemistry, Physical

Restriction boosts piezoelectricity

Sarah Guerin et al.

NATURE MATERIALS (2021)

Add to Collection

Article Multidisciplinary Sciences

A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis

Christina Krienke et al.

Summary: The study demonstrates the potential use of modified m1 Psi mRNA in the treatment of multiple sclerosis, showing its ability to suppress the disease, promote the development of T-reg cell populations, and enhance bystander immunosuppression.

SCIENCE (2021)

Add to Collection

Article Chemistry, Physical

Hybrid artificial cell-mediated epigenetic inhibition in metastatic lung cancer

Qingsheng Peng et al.

Summary: The study encapsulated HDACI into biomimetic nanoparticles to enhance the inhibition of metastatic lung cancer. The physical and chemical properties of nanoparticles and cellular uptake were analyzed in the experiments, and the biological effects were evaluated through various experimental methods.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2021)

Add to Collection

Review Immunology

Nanomaterial Delivery Systems for mRNA Vaccines

Michael D. Buschmann et al.

Summary: This review highlights the recent success of mRNA vaccines in SARS-CoV-2 clinical trials, emphasizing the crucial role of lipid nanoparticles in the delivery systems and providing an analysis of the determinants of lipid nanoparticles' performance in mRNA vaccines.

VACCINES (2021)

Add to Collection

Review Biochemistry & Molecular Biology

mRNA vaccine for cancer immunotherapy

Lei Miao et al.

Summary: mRNA vaccines have emerged as a promising platform for cancer immunotherapy, showcasing high potency, safe administration, rapid development potentials, and cost-effective manufacturing. However, challenges such as stability, innate immunogenicity, and inefficient in vivo delivery restrict their applications. In addressing these challenges, structural modifications and formulation methods are being researched to enhance the anti-tumor immune response.

MOLECULAR CANCER (2021)

Add to Collection

Article Chemistry, Physical

Membrane-destabilizing ionizable phospholipids for organ-selective mRNA delivery and CRISPR-Cas gene editing

Shuai Liu et al.

Summary: The study successfully delivered mRNA or single-guide RNA for gene editing in vivo using combinatorially synthesized ionizable phospholipids. Optimized iPhos lipids can change shapes in endosomal acidic environments to facilitate the release of gene editing materials. When working synergistically with helper lipids, iPhos lipids can achieve targeted delivery to specific organs.

NATURE MATERIALS (2021)

Add to Collection

Article Multidisciplinary Sciences

Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome editing of Angptl3

Min Qiu et al.

Summary: Loss-of-function mutations in Angiopoietin-like 3 (Angptl3) are linked to reduced blood lipid levels, making it a potential therapeutic target for lipid metabolism disorders. A lipid nanoparticle delivery system successfully edited Angptl3 gene in vivo, leading to significant reductions in lipid levels without off-target effects or toxicity, highlighting the potential of this platform for safe and effective gene editing therapies.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Add to Collection

Article Chemistry, Multidisciplinary

mRNA Delivery of a Bispecific Single-Domain Antibody to Polarize Tumor-Associated Macrophages and Synergize Immunotherapy against Liver Malignancies

Ying Wang et al.

Summary: Liver malignancies are resistant to immune checkpoint inhibition therapy due to the presence of tumor-associated macrophages (TAMs) that induce immunosuppression. The study identified CCL2 and CCL5 as major chemokines responsible for TAM infiltration in liver malignancies and developed a bispecific antibody BisCCL2/5i to reverse this immunosuppressive process.

ADVANCED MATERIALS (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Novel approaches for vaccine development

Makda S. Gebre et al.

Summary: Vaccines are crucial for global health, with traditional methods being successful in many cases but facing challenges such as persistent infections and emerging pathogens. Novel technologies like nucleic acid and viral vector vaccines have the potential to revolutionize vaccine development.

CELL (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Impact of lipid nanoparticle size on mRNA vaccine immunogenicity

Kimberly J. Hassett et al.

Summary: The size of LNP particles was found to affect the immunogenicity of vaccines in mice, with smaller diameter LNPs being less immunogenic; however, all particle sizes tested yielded robust immune responses in non-human primates (NHP).

JOURNAL OF CONTROLLED RELEASE (2021)

Add to Collection

Review Engineering, Biomedical

Synthetic modified messenger RNA for therapeutic applications

Minsong Gao et al.

Summary: Synthetic modified mRNA has shown great potential in vaccines and gene therapies, with chemical modifications and delivery systems being key factors for in vivo therapeutic applications. Recent advancements in scalable production and efficient delivery strategies have significantly advanced the field, leading to new discoveries in mRNA modifications and their roles in regulating gene expression.

ACTA BIOMATERIALIA (2021)

Add to Collection

Article Chemistry, Multidisciplinary

All-In-One Dendrimer-Based Lipid Nanoparticles Enable Precise HDR-Mediated Gene Editing In Vivo

Lukas Farbiak et al.

Summary: The study demonstrates the use of dendrimer-based lipid nanoparticles for increasing HDR efficiency in gene editing. By optimizing component ratios, over 91% of cells were edited in vitro, with over 20% HDR efficiency achieved in xenograft tumors in vivo.

ADVANCED MATERIALS (2021)

Add to Collection

Article Engineering, Biomedical

Systemic delivery of mRNA and DNA to the lung using polymer-lipid nanoparticles*

James C. Kaczmarek et al.

Summary: Non-viral vectors can deliver nucleic acids into cells in vivo, with study showing that PBAEs with altered monomer chemistry can effectively deliver DNA or mRNA to lung endothelium in mice. Physical properties like particle size or charge do not explain differences in transfection efficacy, indicating tailored delivery vectors are needed for different nucleic acids. In vivo luciferase expression was significantly higher with mRNA compared to pDNA, highlighting the potential of PBAEs as intracellular delivery materials.

BIOMATERIALS (2021)

Add to Collection

Review Chemistry, Multidisciplinary

Lipids and Lipid Derivatives for RNA Delivery

Yuebao Zhang et al.

Summary: RNA-based therapeutics have shown great promise in treating diseases through various mechanisms, with lipid nanoparticles being the most widely used delivery system. The study of lipids, lipid derivatives, and lipid-derived macromolecules for RNA delivery has also made significant progress in recent years.

CHEMICAL REVIEWS (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Scalable mRNA and siRNA Lipid Nanoparticle Production Using a Parallelized Microfluidic Device

Sarah J. Shepherd et al.

Summary: The study presents a scalable, parallelized microfluidic device (PMD) that can simultaneously operate 128 mixing channels, achieving over 100 times production rate compared to traditional methods for lipid nanoparticles (LNPs). Results demonstrate superior delivery of LNPS generated using PMD in mice, showing potential for emerging clinical applications such as RNA therapeutics and vaccines.

NANO LETTERS (2021)

Add to Collection

Review Nanoscience & Nanotechnology

Lipid nanoparticles for mRNA delivery

Xucheng Hou et al.

Summary: Lipid nanoparticle-mRNA formulations have successfully entered clinical use as COVID-19 vaccines, representing a major milestone in mRNA therapeutics. This review discusses the design of lipid nanoparticles for mRNA delivery, emphasizing key points for clinical translation and preclinical studies of lipid nanoparticle-mRNA therapeutics for various diseases.

NATURE REVIEWS MATERIALS (2021)

Add to Collection

Article Engineering, Biomedical

Optimization of lipid nanoparticles for the delivery of nebulized therapeutic mRNA to the lungs

Melissa P. Lokugamage et al.

Summary: This study optimized the design of lipid nanoparticles for the efficient delivery of therapeutic mRNA to the lungs via nebulization, resulting in protection of mice from a lethal challenge of H1N1 influenza A virus and more efficient delivery of mRNA compared to LNPs previously optimized for systemic delivery. The cluster approach to LNP design may facilitate the optimization of LNPs for other administration routes and therapeutics.

NATURE BIOMEDICAL ENGINEERING (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Ionizable Lipid Nanoparticle-Mediated mRNA Delivery for Human CAR T Cell Engineering

Margaret M. Billingsley et al.

NANO LETTERS (2020)

Add to Collection

Article Chemistry, Physical

The entry of nanoparticles into solid tumours

Shrey Sindhwani et al.

NATURE MATERIALS (2020)

Add to Collection

Article Multidisciplinary Sciences

An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors

Katharina Reinhard et al.

SCIENCE (2020)

Add to Collection

Article Multidisciplinary Sciences

Synergistic lipid compositions for albumin receptor mediated delivery of mRNA to the liver

Lei Miao et al.

NATURE COMMUNICATIONS (2020)

Add to Collection

Article Immunology

Investigating the Impact of Delivery System Design on the Efficacy of Self-Amplifying RNA Vaccines

Giulia Anderluzzi et al.

VACCINES (2020)

Add to Collection

Review Pharmacology & Pharmacy

Lipid nanoparticle technology for therapeutic gene regulation in the liver

Dominik Witzigmann et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

Add to Collection

Article Chemistry, Multidisciplinary

Self-Degradable Lipid-Like Materials Based on Hydrolysis accelerated by the intra-Particle Enrichment of Reactant (HyPER) for Messenger RNA Delivery

Hiroki Tanaka et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

Add to Collection

Article Chemistry, Multidisciplinary

Leveraging mRNA Sequences and Nanoparticles to Deliver SARS-CoV-2 Antigens In Vivo

Chunxi Zeng et al.

ADVANCED MATERIALS (2020)

Add to Collection

Article Multidisciplinary Sciences

An RNA vaccine drives immunity in checkpoint-inhibitor-treated melanoma

Ugur Sahin et al.

NATURE (2020)

Add to Collection

Article Multidisciplinary Sciences

Functionalized lipid-like nanoparticles for in vivo mRNA delivery and base editing

Xinfu Zhang et al.

SCIENCE ADVANCES (2020)

Add to Collection

Article Multidisciplinary Sciences

CRISPR-Cas9 genome editing using targeted lipid nanoparticles for cancer therapy

Daniel Rosenblum et al.

SCIENCE ADVANCES (2020)

Add to Collection

Article Chemistry, Multidisciplinary

Understanding structure-activity relationships of pH-sensitive cationic lipids facilitates the rational identification of promising lipid nanoparticles for delivering siRNAs in vivo

Yusuke Sato et al.

JOURNAL OF CONTROLLED RELEASE (2019)

Add to Collection

Review Biotechnology & Applied Microbiology

Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery

Piotr S. Kowalski et al.

MOLECULAR THERAPY (2019)

Add to Collection

Article Cell Biology

Durable anticancer immunity from intratumoral administration of IL-23, IL-36γ, and OX40L mRNAs

Susannah L. Hewitt et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

Add to Collection

Article Chemistry, Multidisciplinary

Fast and Efficient CRISPR/Cas9 Genome Editing In Vivo Enabled by Bioreducible Lipid and Messenger RNA Nanoparticles

Ji Liu et al.

ADVANCED MATERIALS (2019)

Add to Collection

Article Chemistry, Multidisciplinary

Constrained Nanoparticles Deliver siRNA and sgRNA to T Cells In Vivo without Targeting Ligands

Melissa P. Lokugamage et al.

ADVANCED MATERIALS (2019)

Add to Collection

Article Biotechnology & Applied Microbiology

Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation

Lei Miao et al.

NATURE BIOTECHNOLOGY (2019)

Add to Collection

Article Pharmacology & Pharmacy

Precise tuning of disulphide crosslinking in mRNA polyplex micelles for optimising extracellular and intracellular nuclease tolerability

Anjaneyulu Dirisala et al.

JOURNAL OF DRUG TARGETING (2019)

Add to Collection

Article Chemistry, Multidisciplinary

Branched-Tail Lipid Nanoparticles Potently Deliver mRNA In Vivo due to Enhanced Ionization at Endosomal pH

Khalid A. Hajj et al.

SMALL (2019)

Add to Collection

Article Nanoscience & Nanotechnology

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

Akin Akinc et al.

NATURE NANOTECHNOLOGY (2019)

Add to Collection

Article Chemistry, Organic

Hierarchically Self-Assembled Supramolecular Host–Guest Delivery System for Drug Resistant Cancer Therapy

Hongwei Cheng et al.

BIOMACROMOLECULES (2018)

Add to Collection

Article Materials Science, Biomaterials

Overcoming STC2 mediated drug resistance through drug and gene co-delivery by PHB-PDMAEMA cationic polyester in liver cancer cells

Hongwei Cheng et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2018)

Add to Collection

Article Chemistry, Multidisciplinary

Dendritic Cell Targeting mRNA Lipopolyplexes Combine Strong Antitumor T-Cell Immunity with Improved Inflammatory Safety

Kevin Van der Jeught et al.

ACS NANO (2018)

Add to Collection

Article Pharmacology & Pharmacy

Biodegradable lipid nanoparticles induce a prolonged RNA interference-mediated protein knockdown and show rapid hepatic clearance in mice and nonhuman primates

Yuta Suzuki et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

Add to Collection

Article Biotechnology & Applied Microbiology

Lipid Nanoparticle Systems for Enabling Gene Therapies

Pieter R. Cullis et al.

MOLECULAR THERAPY (2017)

Add to Collection

Article Chemistry, Multidisciplinary

A lipid nanoparticle for the efficient delivery of siRNA to dendritic cells

Shota Warashina et al.

JOURNAL OF CONTROLLED RELEASE (2016)

Add to Collection

Article Multidisciplinary Sciences

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

Lena M. Kranz et al.

NATURE (2016)

Add to Collection

Article Multidisciplinary Sciences

Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model

Kejin Zhou et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Add to Collection

Article Chemistry, Multidisciplinary

A neutral lipid envelope-type nanoparticle composed of a pH-activated and vitamin E-scaffold lipid-like material as a platform for a gene carrier targeting renal cell carcinoma

Hidetaka Akita et al.

JOURNAL OF CONTROLLED RELEASE (2015)

Add to Collection

Article Chemistry, Multidisciplinary

An Orthogonal Array Optimization of Lipid-like Nanoparticles for mRNA Delivery in Vivo

Bin Li et al.

NANO LETTERS (2015)

Add to Collection

Article Chemistry, Multidisciplinary

A new adjuvant delivery system 'cyclic di-GMP/YSK05 liposome' for cancer immunotherapy

Hiroko Miyabe et al.

JOURNAL OF CONTROLLED RELEASE (2014)

Add to Collection

Article Medicine, Research & Experimental

Stabilization of Ostwald Ripening in Low Molecular Weight Amino Lipid Nanoparticles for Systemic Delivery of siRNA Therapeutics

Marian E. Gindy et al.

MOLECULAR PHARMACEUTICS (2014)

Add to Collection

Article Multidisciplinary Sciences

Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity

Kathryn A. Whitehead et al.

NATURE COMMUNICATIONS (2014)

Add to Collection

Article Biotechnology & Applied Microbiology

Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics

Martin A. Maier et al.

MOLECULAR THERAPY (2013)

Add to Collection

Article Biochemistry & Molecular Biology

Synthesis and characterization of degradable multivalent cationic lipids with disulfide-bond spacers for gene delivery

Rahau S. Shirazi et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2011)

Add to Collection

Article Biotechnology & Applied Microbiology

Rational design of cationic lipids for siRNA delivery

Sean C. Semple et al.

NATURE BIOTECHNOLOGY (2010)

Add to Collection

Article Biotechnology & Applied Microbiology

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

Akin Akinc et al.

NATURE BIOTECHNOLOGY (2008)

Add to Collection

Article Chemistry, Multidisciplinary

Cationic lipid saturation influences intracellular delivery of encapsulated nucleic acids

J Heyes et al.

JOURNAL OF CONTROLLED RELEASE (2005)

Add to Collection

© Peeref 2019-2024. All rights reserved.