Journal
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2022.980112
Keywords
shear stress; endothelial microparticles; vascular homeostasis; endothelial dysfunction; atherosclerosis
Categories
Funding
- National Natural Science Foundation of China
- Shanghai Municipal Commission of Health and Family Planning
- Shanghai High School Fellowship Program for Research and Translation
- Technology Transfer Project of Shanghai Jiao Tong University School of Medicine
- [81870179]
- [82000369]
- [82170423]
- [20194Y0042]
- [RC0030103]
- [ZT202103]
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Hemodynamic shear stress (SS) regulates vascular homeostasis and injury through the release of endothelial microparticles (EMP), affecting physiological function of endothelial cells, inflammatory response, vascular permeability, and the coagulation system.
Hemodynamic shear stress (SS), a frictional force generated by blood flow, regulates vascular homeostasis. High and steady SS maintains physiological function of endothelial cells while low and disturbed SS promotes disturbance of vascular homeostasis and the development of atherosclerosis. Endothelial microparticle (EMP), a vesicular structure shed from endothelial cells, has emerged as a surrogate biomarker of endothelial injury and dysfunction. EMP release is triggered by disturbed SS in addition to multiple inflammatory cytokines. This review systematically summarizes the impact of SS on EMPs and the role of EMPs under SS in modulating vascular homeostasis and injury, including endothelial survival, vasodilation, inflammatory response, vascular permeability, and coagulation system.
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