Journal
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2022.967909
Keywords
PP2A phosphatase; cyclin B; Cdk1; greatwall; ARPP19; ENSA; mitosis
Categories
Funding
- Agence National de la Recherche [ANR-18-CE13-0013, ANR-18-CE13-0018-01, ANR-20-CE13-0033]
- La Ligue Nationale Contre le Cancer (Equipe Labellisee, EL2019 CASTRO)
- La Ligue Nationale Contre le Cancer (Comite Departement 66)
- LABEX EpiGenMed [ANR-10-LABEX-12-01]
- Agence Nationale de la Recherche (ANR) [ANR-18-CE13-0013] Funding Source: Agence Nationale de la Recherche (ANR)
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Proper repartition of DNA during cell division requires major physical changes, including nuclear envelope breakdown, DNA condensation, and spindle formation. These changes are regulated by the balance between protein kinases and phosphatases. While the role of kinases in mitosis has been extensively studied, the importance of phosphatases has been underestimated. Recent research has highlighted the crucial role of the phosphatase holoenzyme PP2A-B55 in regulating cell division events. This review focuses on the latest insights into the structure, biochemistry, and enzymatic mechanisms of PP2A-B55 phosphatase and its regulators.
Cells require major physical changes to induce a proper repartition of the DNA. Nuclear envelope breakdown, DNA condensation and spindle formation are promoted at mitotic entry by massive protein phosphorylation and reversed at mitotic exit by the timely and ordered dephosphorylation of mitotic substrates. This phosphorylation results from the balance between the activity of kinases and phosphatases. The role of kinases in the control of mitosis has been largely studied, however, the impact of phosphatases has long been underestimated. Recent data have now established that the regulation of phosphatases is crucial to confer timely and ordered cellular events required for cell division. One major phosphatase involved in this process is the phosphatase holoenzyme PP2A-B55. This review will be focused in the latest structural, biochemical and enzymatic insights provided for PP2A-B55 phosphatase as well as its regulators and mechanisms of action.
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