Journal
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2022.1022723
Keywords
cancer; metastasis; cell migration; nuclear size; NET; lamin; karyoplasmic ratio; nuclear envelope
Categories
Funding
- Academy of Finland
- Sigrid Juselius Foundation [317871, 334774, 350887]
- Cancer Society of Finland
- Vaere lasten syoepaesaeaetioe
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Research suggests that changes in nuclear size are associated with tumor metastasis. Recent studies have found that reversing tumor type-dependent nuclear size changes is correlated with reduced cell migration and invasion.
Research on metastasis has recently regained considerable interest with the hope that single cell technologies might reveal the most critical changes that support tumor spread. However, it is possible that part of the answer has been visible through the microscope for close to 200 years. Changes in nuclear size characteristically occur in many cancer types when the cells metastasize. This was initially discarded as contributing to the metastatic spread because, depending on tumor types, both increases and decreases in nuclear size could correlate with increased metastasis. However, recent work on nuclear mechanics and the connectivity between chromatin, the nucleoskeleton, and the cytoskeleton indicate that changes in this connectivity can have profound impacts on cell mobility and invasiveness. Critically, a recent study found that reversing tumor type-dependent nuclear size changes correlated with reduced cell migration and invasion. Accordingly, it seems appropriate to now revisit possible contributory roles of nuclear size changes to metastasis.
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