Journal
JCI INSIGHT
Volume 7, Issue 21, Pages -Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/jci.insight.161244
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Funding
- National Natural Science Foundation of China [81801970, 81970553, 82070668, 82070669]
- Cultivation Foundation of Yangzhou Municipal Key Laboratory [YZ2021147]
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Acute pancreatitis is an inflammatory disease with no effective medical treatment. IL-37 has anti-inflammatory effects and can protect pancreatic cells from death.
Acute pancreatitis (AP) is a local and/or systemic inflammatory disease that starts with acinar cell injury and necrosis; it has no effective medical treatment and thus remains a lifethreatening condition. Interleukin-37 (IL-37), a natural immunomodulator, has demonstrated an antiinflammatory effect; however, the role of IL-37 in AP remains unknown. The serum IL-37 levels of 39 healthy controls and 94 patients with AP were measured. Cholecystokinin was applied to induce pancreatic acinar cell injury in vitro. Classical experimental AP models, such as caerulein, l-arginine, and taurolithocholic acid 3-sulfate disodium salt, were included in the in vivo study. A transgenic mouse model with the IL-37 gene and administration of recombinant ILresults showed that serum IL-37 levels in humans were negatively correlated with the severity of protect against AP. Mechanistically, IL-37 was able to suppress pyroptosis of injured acinar cells, study demonstrates that IL-37 protects against acinar cell pyroptosis in AP.
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