The human gut serves as a reservoir of hypervirulent Klebsiella pneumoniae

Hypervirulent Klebsiella pneumoniae (hvKp) can cause serious infections and has been increasingly reported clinically. However, we still lack the knowledge to what degree hvKp colonize the community. In this study, we investigated colonization of hvKp in healthy human gut and the relationship between gut hvKp and clinically important invasive strains. We compile global genomes of gut K. pneumoniae for in-depth genetic analysis and found most hvKp genomes originated from Chinese datasets; therefore, we collected gut K. pneumoniae isolates from healthy people around China. The results revealed a moderate carriage rate of hvKp in the healthy population (4%-5.19%). Phylogenetic analysis indicated a close relationship between gut hvKp and fatal clinical strains. These results demonstrate that the human gut may serve as a reservoir of hvKp and that gut hvKp can play a role in infection of other body parts.

Automated summary

This study investigated the colonization of hypervirulent Klebsiella pneumoniae (hvKp) in the healthy population and its relationship with clinically important strains. The results showed that the human gut may serve as a reservoir of hvKp and that hvKp in the gut can play a role in infection of other body parts, highlighting the importance of understanding the transmission and controlling the infection of hvKp.