Journal
JOURNAL OF MEDICAL MICROBIOLOGY
Volume 65, Issue -, Pages 770-774Publisher
MICROBIOLOGY SOC
DOI: 10.1099/jmm.0.000301
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Funding
- National Council for Scientific and Technological Development (CNPq) [470229/2012-8]
- CAPES (Higher Education Personnel Training Coordination, Brazil)
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The genus Fusarium is characterized by hyaline filamentous fungi that cause infections predominantly in immunocompromised patients. The remarkable primary resistance to antifungal agents of this genus requires a search for new therapeutic possibilities. This study assessed the in vitro susceptibility of 25 clinical isolates of Fusarium against antifungal agents (amphotericin B, caspofungin, itraconazole and voriconazole) and antimicrobials (pentamidine, polymyxin B, tigecycline and tobramycin) according to the broth microdilution method (M38-A2). The interactions between antifungal and antimicrobial agents were evaluated by the microdilution checkerboard method. Pentamidine and polymyxin B showed MIC values >= 4 mu g ml(-1) against Fusarium spp. The highest rates of synergism were observed when amphotericin B or voriconazole was combined with tobramycin (80 % and 76 %, respectively), polymyxin B (76 % and 64 %) and pentamidine (72 % and 68 %). The most significant combinations deserve in vivo evaluations in order to verify their potential in the treatment of fusariosis.
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