4.6 Article

Green Extraction Process of Food Grade C-phycocyanin: Biological Effects and Metabolic Study in Mice

Journal

PROCESSES
Volume 10, Issue 9, Pages -

Publisher

MDPI
DOI: 10.3390/pr10091793

Keywords

green chemistry; antioxidant activity; oral glucose tolerance test-OGTT

Funding

  1. Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-Brasil (CAPES) [88887.364166/2019-00]
  2. Fundacao de Amparo a Pesquisa do Estado de Sao Paulo-FAPESP [2020/07046-0, 2020/06732-7]

Ask authors/readers for more resources

This study evaluated the impact of different parameters in the green process of extracting C-phycocyanin from organic Spirulina biomass on weight and oral glucose tolerance in Swiss mice fed with a high-fat diet. The results showed that supplementation of Spirulina biomass in the HFDS group did not exhibit antiobesogenic potential with an HFD, but further studies are needed to explore other interesting responses regarding C-PC biological effects in vivo.
This study aimed to evaluate different parameters in the green process of organic Spirulina biomass (SB) C-phycocyanin (C-PC) extraction to understand the impact on weight and oral glucose tolerance of C-PC extract in Swiss mice fed with a high-fat diet (HFD). The proximate composition and antioxidant activity were analyzed in Spirulina by-products: SB, C-PC, and Remaining biomass (RB). The protein content on a dry basis was 52.05% in SB and 61.16% in RB and 118.97 mu g/g in C-PC. The antioxidant activity was equal for SB and C-PC but higher than RB. However, RB can be considered a promising ingredient, promoting the sustainable use of the whole SB. Swiss mice were distributed in five groups: control diet (CD), HFD, HFD plus Spirulina biomass (HFDS), HFD plus C-PC (HFDC), and HFD plus remaining biomass (HFDR). HFDS increased the delta weight of the animals and showed glucose intolerance compared to the CD and HFDC groups. The results demonstrated that the supplementation of 500 mg/kg of body weight of SB in the HFDS group did not show antiobesogenic potential with an HFD, but it is essential to conduct further studies to bring other interesting responses regarding C-PC biological in vivo effects.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available