Related references
Note: Only part of the references are listed.
Letter
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Summary: This study analyzed the US Department of Veterans Affairs national healthcare databases to investigate the occurrence of Long COVID and death risk after breakthrough SARS-CoV-2 infection. The findings showed that vaccination significantly reduced the risk of death and post-acute sequelae but did not eliminate them completely. These results underscore the importance of further research on prevention and post-acute care for breakthrough infections.
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Summary: A study using data from Israel's largest health-care organization showed that a third dose of the BNT162b2 mRNA vaccine is effective in preventing individuals from severe COVID-19-related outcomes, compared to receiving only two doses at least 5 months ago. The effectiveness of the third dose in preventing hospital admission was 93%, severe disease 92%, and COVID-19-related death 81%.
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Summary: A study conducted in Israel on nearly 600,000 individuals showed that the BNT162b2 mRNA vaccine was effective in reducing the risk of infection, hospitalization, and severe Covid-19. The effectiveness in preventing death was 72% during the period from day 14 through day 20 after the first dose, and hospitalization was reduced by 87% for the period 7 or more days after the second dose, similar to results from a randomized trial.
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Louise Sigfrid et al.
Summary: Very little is currently known about the possible clinical sequelae that may persist after resolution of acute COVID-19. A recent longitudinal cohort study from Italy reported that 87% of patients had at least one ongoing symptom at 60-day follow-up after hospitalisation with COVID-19, suggesting that COVID-19 patients may require more psychological support than typical ICU patients. This study aims to characterize physical and psychosocial sequelae in patients post-COVID-19 hospital discharge and provide insights for long-term consequences prevention and clinical management.
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Summary: Research has shown a decrease in anti-S1 antibodies and an increase in specific spike (S) T-cells, mainly from the CD8+ compartment, in individuals vaccinated with BNT162b2. There is significant variability in the CD4+ S-specific response among vaccinated individuals. These findings suggest a shift from antibody response to memory cell consolidation in protecting against severe effects of SARS-CoV-2 infection.
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Eleftheria Vasileiou et al.
Summary: The study in Scotland found that the first doses of the BNT162b2 mRNA and ChAdOx1 vaccines were associated with substantial reductions in the risk of COVID-19 hospital admission, with vaccine effectiveness ranging from 88% to 91% at 28-34 days post-vaccination.
Review
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Francesca Salamanna et al.
Summary: A substantial proportion of COVID-19 patients experience long-term symptoms after recovery, including abnormal lung functions, neurologic complaints, olfactory dysfunctions, chronic fatigue, and pain. Despite the heterogeneity in studies, findings highlight the presence of a post-COVID syndrome in a noteworthy proportion of patients who have suffered from SARS-CoV-2 infection.
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(2021)
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Olalekan Lee Aiyegbusi et al.
Summary: Patients with long COVID experience a wide range of physical and mental symptoms, with common issues including fatigue, shortness of breath, and headaches. Beyond symptoms and complications, they often report impaired quality of life, mental health issues, and employment problems.
JOURNAL OF THE ROYAL SOCIETY OF MEDICINE
(2021)
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David A. Henry et al.
Summary: Community-based studies in five countries consistently show strong benefits from early rollouts of COVID-19 vaccines.
MEDICAL JOURNAL OF AUSTRALIA
(2021)
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Moriah Bergwerk et al.
Summary: Among fully vaccinated health care workers, breakthrough infections with SARS-CoV-2 were correlated with neutralizing antibody titers during the peri-infection period. Most breakthrough infections were mild or asymptomatic, although persistent symptoms did occur.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Immunology
Petra Zimmermann et al.
Summary: Distinguishing long-term SARS-CoV-2 infection-associated symptoms from pandemic-associated symptoms presents challenges in research findings.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2021)
News Item
Medicine, General & Internal
Janice Hopkins Tanne
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Article
Multidisciplinary Sciences
Petra Mlcochova et al.
Summary: The B.1.617.2 (Delta) variant of SARS-CoV-2 has lower sensitivity to antibodies and higher replication efficiency compared to other lineages, which may contribute to its dominance and reduced vaccine effectiveness, highlighting the need for continued infection control measures post-vaccination.
Review
Public, Environmental & Occupational Health
Melina Michelen et al.
Summary: Long COVID is a complex condition with prolonged and heterogeneous symptoms, including weakness, general malaise, fatigue, concentration impairment, and breathlessness. Approximately 37% of patients reported reduced quality of life, and 26% of studies presented evidence of reduced pulmonary function. There is an urgent need for further studies to explore the etiology, risk factors, and biomarkers of long COVID in different populations and settings.
Letter
Medicine, General & Internal
Angelo Carfi et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2020)
Article
Medicine, General & Internal
The Lancet
