4.7 Article

Structural Optimization of Platinum Drugs to Improve the Drug-Loading and Antitumor Efficacy of PLGA Nanoparticles

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Synthesis, Biological Evaluation and Molecular Docking Studies of 5-Indolylmethylen-4-oxo-2-thioxothiazolidine Derivatives

Volodymyr Horishny et al.

Summary: The paper presents the synthesis and evaluation of a series of antimicrobial compounds. The results show that these compounds exhibit good antibacterial and antifungal activities, with three of the most active compounds being potential candidates for the development of more potent and safe antimicrobial agents.

MOLECULES (2022)

Article Instruments & Instrumentation

Improving dexamethasone drug loading and efficacy in treating arthritis through a lipophilic prodrug entrapped into PLGA-PEG nanoparticles

Rosana Simon-Vazquez et al.

Summary: Encapsulation of dexamethasone palmitate into nanoparticles can enhance drug loading and reduce side effects, leading to improved efficacy in treating arthritis.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2022)

Article Chemistry, Inorganic & Nuclear

Modeling Drugs-PLGA Nanoparticles Interactions Using Gaussian Processes: Pharmaceutics Informatics Approach

Rania M. Hathout et al.

Summary: This study successfully modeled the interactions between drugs and PLGA nanoparticles using Gaussian Processes, predicting the bias percentage of drug binding energies. The adoption of Pharmaceutics Informatics approach can save the pharmaceutical industry and drug delivery scientists a significant amount of resources, efforts, and time.

JOURNAL OF CLUSTER SCIENCE (2022)

Article Multidisciplinary Sciences

Comparative statistical analysis of the release kinetics models for nanoprecipitated drug delivery systems based on poly(lactic-co-glycolic acid)

Nathaly S. Heredia et al.

Summary: Poly(lactic-co-glycolic acid) (PLGA) is a commonly used polymer in drug delivery systems, exhibiting excellent biocompatibility, biodegradability, and spatio-temporal control of drug release. However, there is no general model that can describe all types of drug release in polymeric drug delivery systems. This study compared several mathematical models and found that the Hyperbolic Tangent Function model best fitted the drug release profile of PLGA particles synthesized by nanoprecipitation method.

PLOS ONE (2022)

Article Oncology

Carboplatin dose calculations for patients with lung cancer: significant dose differences found depending on dosing equation choice

Seckin Akgul et al.

Summary: Carboplatin dosage varies depending on the equation used, with the CKD-EPI formula providing the most accurate estimation. Implementing CKD-EPI as the new standard of care for carboplatin dosing internationally is recommended.

BMC CANCER (2022)

Article Biotechnology & Applied Microbiology

Alpha-fetoprotein mediated targeting of polymeric nanoparticles to treat solid tumors

Mariya B. Sokol et al.

Summary: This study successfully increased the safety profile of paclitaxel by designing paclitaxel-loaded nanoparticles rAFP3d-NP. rAFP3d-NP showed high loading content and moderate size, with appropriate release rate and prolonged blood circulation. The study also found significant tumor growth inhibition by rAFP3d-NP.

NANOMEDICINE (2022)

Review Chemistry, Inorganic & Nuclear

A chemical perspective on the clinical use of platinum-based anticancer drugs

Shoohb Alassadi et al.

Summary: Platinum drugs have been widely used in cancer chemotherapy and can be combined with other drugs. The formulation and pharmacokinetics of platinum drugs play important roles in their efficacy and safety. However, controlling platinum pharmacokinetics and side effects remains a challenge. Co-administration of other drugs in cancer patients may potentially affect the efficacy and side effects of platinum drugs.

DALTON TRANSACTIONS (2022)

Article Chemistry, Inorganic & Nuclear

Anticancer and Apoptotic-Inducing Effects of Rutin-Chitosan Nanoconjugates in Triple Negative Breast Cancer Cells

Cheng Chang et al.

Summary: The study focused on the anti-breast cancer activity of rutin-chitosan nanoconjugates, which showed significant activity against Triple Negative Breast Cancer (TNBC) cells with an IC50 of 12.5 μg/mL. The nanoconjugates also induced cell cycle arrest and apoptotic cell deaths, suggesting their potential application in anti-cancer therapies.

JOURNAL OF CLUSTER SCIENCE (2021)

Review Chemistry, Medicinal

Evolution of the Computational Pharmaceutics Approaches in the Modeling and Prediction of Drug Payload in Lipid and Polymeric Nanocarriers

Shaymaa A. Abd-algaleel et al.

Summary: This review summarizes different trials for modeling and predicting drug payload in lipid and polymeric nanocarriers. It discusses the evolution of the field from early attempts using solubility and Flory-Huggins models to the emergence of molecular dynamic simulations and docking studies, and finally to the successful era of artificial intelligence and machine learning. Key aspects are reviewed through sequential examples that highlight both matching and poorly matching studies with wet lab-dry lab results.

PHARMACEUTICALS (2021)

Article Chemistry, Inorganic & Nuclear

Can the Docking Experiments Select the Optimum Natural Bio-macromolecule for Doxorubicin Delivery?

Heba A. Gad et al.

Summary: The study explores the possibility of using molecular dynamics and docking experiments to select a suitable natural bio-macromolecule for loading doxorubicin into nanoparticles, aiming at improving drug loading efficiency and release rate. The results of docking experiments are highly correlated with the loading data obtained from literature, demonstrating the reliability and effectiveness of docking experiments in selecting drug carriers.

JOURNAL OF CLUSTER SCIENCE (2021)

Article Biochemistry & Molecular Biology

Optimization, Characterization and Pharmacokinetic Study of Meso-Tetraphenylporphyrin Metal Complex-Loaded PLGA Nanoparticles

Mariia R. Mollaeva et al.

Summary: Statistical analysis was used to optimize the preparation of metalloporphyrin-loaded nanoparticles, which exhibited good physicochemical properties and significant effectiveness in delivering the metalloporphyrins to cancer cells, showing potential antitumor activity.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Engineering, Biomedical

Influence of lactide vs glycolide composition of poly (lactic-co-glycolic acid) polymers on encapsulation of hydrophobic molecules: molecular dynamics and formulation studies

Anurag Dobhal et al.

Summary: The study demonstrated the preparation of PLGA nanoparticles using a microreactor-based continuous process to encapsulate a hydrophobic molecule, and characterized the formulations for size, homogeneity, zeta potential, and surface morphology. The nanoparticles were found to be safe and effectively taken up by CHO cells, with molecular dynamics simulations revealing differences in compatibility based on polymer chain length and LA:GA ratio.

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE (2021)

Review Materials Science, Multidisciplinary

PLGA-based drug delivery system for combined therapy of cancer: research progress

Zhang Ruirui et al.

Summary: PLGA micro/nano particle drug delivery systems have been widely used in cancer treatment in recent years. The unique properties of PLGA allow for the effective loading of molecules and improvement in bioavailability. Research has focused on the use of PLGA-based drug carrier systems in tumor combination therapy.

MATERIALS RESEARCH EXPRESS (2021)

Article Biochemistry & Molecular Biology

Oxidative Damage Induced by Phototoxic Pheophorbide a 17-Diethylene Glycol Ester Encapsulated in PLGA Nanoparticles

Mariia R. Mollaeva et al.

Summary: The novel XL-8 loaded nanoparticles showed high loading content and encapsulation efficiency, specific intracellular accumulation, and sustained release properties. They demonstrated significant phototoxicity and enhanced photostability, indicating great potential for further in vivo studies.

ANTIOXIDANTS (2021)

Review Pharmacology & Pharmacy

FDA's Poly (Lactic-Co-Glycolic Acid) Research Program and Regulatory Outcomes

Yan Wang et al.

Summary: The FDA's research program on PLGA focuses on addressing challenges in generic development, including analytical tools for characterization, impact of PLGA characteristics, in vitro drug release testing and modeling tools. Successful research investigations have yielded scientific accomplishments and regulatory outcomes.

AAPS JOURNAL (2021)

Article Polymer Science

Molecular dynamics simulations of quinine encapsulation into biodegradable nanoparticles: A possible new strategy against Sars-CoV-2

Pierluigi Stipa et al.

Summary: With the absence of specific therapeutic drugs for treating COVID-19, studies suggest that antimalarial quinine and its derivatives may inhibit the virus and cytokine storms. Quinine is considered safer, but dosage optimization and repurposing dosage forms are necessary. Biodegradable polymeric nanoparticles could provide a safer and controlled delivery system for quinine, potentially improving its efficacy against SARS-CoV-2.

EUROPEAN POLYMER JOURNAL (2021)

Review Health Care Sciences & Services

The Enhanced Permeability and Retention (EPR) Effect: The Significance of the Concept and Methods to Enhance Its Application

Jun Wu

Summary: Chemotherapy for human solid tumors faces challenges in delivering anticancer compounds selectively into tumor tissues to maintain effective concentration levels for a certain duration, hindering the execution of anticancer activities. Targeting therapy via the enhanced permeability and retention effect may not always be successful, as it depends on tumor type, location, blood perfusion status, and properties of macromolecular anticancer agents. Efforts to maximize the EPR effect in developing smarter nanomedicines are essential for successful clinical applications.

JOURNAL OF PERSONALIZED MEDICINE (2021)

Review Nanoscience & Nanotechnology

Nanoparticles for Cancer Therapy: Current Progress and Challenges

Shreelaxmi Gavas et al.

Summary: Nanotechnology has revolutionized cancer diagnosis and treatment by overcoming limitations of traditional therapies and multidrug resistance. Nanoparticles, with their unique advantages, offer new perspectives for cancer treatment. However, challenges still exist in research and clinical translation of nanotherapeutics.

NANOSCALE RESEARCH LETTERS (2021)

Review Oncology

The rediscovery of platinum-based cancer therapy

Sven Rottenberg et al.

Summary: Platinum chemotherapy agents continue to be widely used in cancer treatment, with recent insights into DNA repair mechanisms providing valuable explanations for their success. The understanding of defective DNA repair in many cancers sheds new light on secondary drug resistance mechanisms.

NATURE REVIEWS CANCER (2021)

Article Biochemistry & Molecular Biology

S-benzyldithiocarbazate imine coordinated metal complexes kill Candida albicans by causing cellular apoptosis and necrosis

Manzoor Ahmad Malik et al.

BIOORGANIC CHEMISTRY (2020)

Review Pharmacology & Pharmacy

Endocytosis: The Nanoparticle and Submicron Nanocompounds Gateway into the Cell

Dario Manzanares et al.

PHARMACEUTICS (2020)

Article Biochemistry & Molecular Biology

On Calculating Free Energy Differences Using Ensembles of Transition Paths

Robert Hall et al.

FRONTIERS IN MOLECULAR BIOSCIENCES (2020)

Review Materials Science, Biomaterials

Phenomenology of the Initial Burst Release of Drugs from PLGA Microparticles

Jin Yoo et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

Review Biochemistry & Molecular Biology

Nanoparticle-Based Drug Delivery in Cancer Therapy and Its Role in Overcoming Drug Resistance

Yihan Yao et al.

FRONTIERS IN MOLECULAR BIOSCIENCES (2020)

Review Chemistry, Inorganic & Nuclear

Platinum iodido complexes: A comprehensive overview of anticancer activity and mechanisms of action

Pavel Starha et al.

COORDINATION CHEMISTRY REVIEWS (2019)

Review Chemistry, Inorganic & Nuclear

The clinical development of carboplatin - A personal perspective

Hilary Calvert

INORGANICA CHIMICA ACTA (2019)

Article Nanoscience & Nanotechnology

In vitro-in vivo evaluation of chitosan-PLGA nanoparticles for potentiated gastric retention and anti-ulcer activity of diosmin

Walaa Ebrahim Abd El Hady et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

Article Biochemistry & Molecular Biology

Keratin nanoparticles co-delivering Docetaxel and Chlorin e6 promote synergic interaction between chemo- and photo-dynamic therapies

Elisa Gaio et al.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY (2019)

Review Chemistry, Multidisciplinary

Computer-aided prediction of biological activity spectra for organic compounds: the possibilities and limitations

V. V. Poroikov et al.

RUSSIAN CHEMICAL BULLETIN (2019)

Article Engineering, Biomedical

Formulation of Antimicrobial Tobramycin Loaded PLGA Nanoparticles via Complexation with AOT

Marcus Hill et al.

JOURNAL OF FUNCTIONAL BIOMATERIALS (2019)

Review Chemistry, Inorganic & Nuclear

The side effects of platinum-based chemotherapy drugs: a review for chemists

Rabbab Oun et al.

DALTON TRANSACTIONS (2018)

Article Chemistry, Multidisciplinary

Organic synthesis provides opportunities to transform drug discovery

David C. Blakemore et al.

NATURE CHEMISTRY (2018)

Article Food Science & Technology

Bioactive Starch Foam Composite Enriched With Natural Antioxidants from Spent Coffee Ground and Essential Oil

Khuanruthai Trongchuen et al.

STARCH-STARKE (2018)

Article Chemistry, Physical

Electrochemically Enhanced Drug Delivery Using Polypyrrole Films

Sayed Ashfaq Ali Shah et al.

MATERIALS (2018)

Article Polymer Science

Formulation of functionalized PLGA nanoparticles with folic acid-conjugated chitosan for carboplatin encapsulation

Daniel de Moraes Profirio et al.

EUROPEAN POLYMER JOURNAL (2018)

Review Pharmacology & Pharmacy

PLGA-Based Nanoparticles in Cancer Treatment

Sima Rezvantalab et al.

FRONTIERS IN PHARMACOLOGY (2018)

Article Multidisciplinary Sciences

Epigenetic and antitumor effects of platinum (IV)-octanoato conjugates

Vojtech Novohradsky et al.

SCIENTIFIC REPORTS (2017)

Review Oncology

Platinum-based drugs: past, present and future

Shahana Dilruba et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2016)

Review Chemistry, Inorganic & Nuclear

More of a misunderstanding than a real mismatch? Platinum and its affinity for aqua, hydroxido, and oxido ligands

Bernhard Lippert et al.

COORDINATION CHEMISTRY REVIEWS (2016)

Review Biochemistry & Molecular Biology

Insights into Protein-Ligand Interactions: Mechanisms, Models, and Methods

Xing Du et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

Article Biochemistry & Molecular Biology

Synthesis and pharmacological evaluation of N-benzyl substituted 4-bromo-2,5-dimethoxyphenethylamines as 5-HT2A/2C partial agonists

Martin Hansen et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2015)

Article Chemistry, Medicinal

Study on Antitumor Platinum(II) Complexes of Chiral Diamines with Dicyclic Species as Steric Hindrance

Fengfan Liu et al.

JOURNAL OF MEDICINAL CHEMISTRY (2015)

Article Chemistry, Inorganic & Nuclear

Benzyl-substituted carbene-metal complexes: Potential for novel antibiotics and anticancer drugs?

Matthias Tacke

JOURNAL OF ORGANOMETALLIC CHEMISTRY (2015)

Article Medicine, Research & Experimental

Computer-Assisted Drug Formulation Design: Novel Approach in Drug Delivery

Abdelkader A. Metwally et al.

MOLECULAR PHARMACEUTICS (2015)

Article Pharmacology & Pharmacy

Encapsulation in Nanoparticles Improves Anti-cancer Efficacy of Carboplatin

Tanmoy Sadhukha et al.

AAPS PHARMSCITECH (2014)

Article Chemistry, Inorganic & Nuclear

The Effect of Ligand Lipophilicity on the Nanoparticle Encapsulation of Pt(IV) Prodrugs

Timothy C. Johnstone et al.

INORGANIC CHEMISTRY (2013)

Article Chemistry, Physical

The fundamental role of flexibility on the strength of molecular binding

Christopher Forrey et al.

SOFT MATTER (2012)

Review Pharmacology & Pharmacy

Higuchi equation: Derivation, applications, use and misuse

Juergen Siepmann et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2011)

Article Pharmacology & Pharmacy

DDSolver: An Add-In Program for Modeling and Comparison of Drug Dissolution Profiles

Yong Zhang et al.

AAPS JOURNAL (2010)

Article Chemistry, Multidisciplinary

Method for analysis of nanoparticle hemolytic properties in vitro

Marina A. Dobrovoiskaia et al.

NANO LETTERS (2008)

Review Oncology

Mechanisms of resistance to cisplatin and carboplatin

David J. Stewart

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2007)

Article Chemistry, Inorganic & Nuclear

Carboplatin derivatives with superior antitumor activity compared to the parent compound

G Bernhardt et al.

INORGANICA CHIMICA ACTA (2004)

Review Pharmacology & Pharmacy

Modeling and comparison of dissolution profiles

P Costa et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2001)