4.7 Article

Ultrasound-Triggerable Coatings for Foley Catheter Balloons for Local Release of Anti-Inflammatory Drugs during Bladder Neck Dilation

Journal

PHARMACEUTICS
Volume 14, Issue 10, Pages -

Publisher

MDPI
DOI: 10.3390/pharmaceutics14102186

Keywords

ultrasound-induced release; ultrasound-sensitive coatings; PLA coating; local drug delivery; microchamber arrays; anti-inflammatory drug; methylprednisolone sodium succinate; Prednol-L; Foley catheter; balloon dilation; bladder neck contracture

Funding

  1. Siberian State Medical University
  2. Russian Federation [MK-4273.2021.1.4]

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Bladder neck contracture is a complication of prostate surgery that can cause urinary blockage. Current treatment requires multiple surgeries with uncertain outcomes. A study has developed a biocompatible coating that releases medication under ultrasound guidance, and showed its safety in animal experiments.
Bladder neck contracture (BNC) is a complication of the surgical treatment of benign and malignant prostate conditions and is associated with the partial or complete blockage of urination. Correction of this condition usually requires repeated surgical intervention, which does not guarantee recovery. Balloon dilation is a minimally invasive alternative to the surgical dissection of tissues; however, it significantly reduces the patient's quality of life. Additional local anti-inflammatory treatment may reduce the number of procedures requested and increase the attractiveness of this therapeutic strategy. Here, we report about an ultrathin biocompatible coating based on polylactic acid for Foley catheter balloons that can provide localized release of Prednol-L in the range of 56-99 mu g in the BNC zone under conventional diagnostic ultrasound exposure. Note that the exposure of a transrectal probe with a conventional gray-scale ultrasound regimen with and without shear wave elastography (SWE) was comparably effective for Prednol-L release from the coating surface of a Foley catheter balloon. This strategy does not require additional manipulations by clinicians. The trigger for the drug release is the ultrasound exposure, which is applied for visualization of the balloon's location during the dilation process. In vivo experiments demonstrated the absence of negative effects of the usage of a coated Foley catheter for balloon dilation of the bladder neck and urethra.

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