Journal
PHARMACEUTICS
Volume 14, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/pharmaceutics14091936
Keywords
antibiotic resistance; phage therapy; phage stabilization; lyophilization; encapsulation; nano-assisted stabilization; polymers
Categories
Funding
- National Science Centre within the SONATA BIS grant [2017/26/E/ST4/00041]
Ask authors/readers for more resources
This article introduces various formulations to enhance the stability of phages, including polymer-based stabilization, encapsulation, lyophilization, and nano-assisted solutions.
Phages are efficient in diagnosing, treating, and preventing various diseases, and as sensing elements in biosensors. Phage display alone has gained attention over the past decade, especially in pharmaceuticals. Bacteriophages have also found importance in research aiming to fight viruses and in the consequent formulation of antiviral agents and vaccines. All these applications require control over the stability of virions. Phages are considered resistant to various harsh conditions. However, stability-determining parameters are usually the only additional factors in phage-related applications. Phages face instability and activity loss when preserved for extended periods. Sudden environmental changes, including exposure to UV light, temperature, pH, and salt concentration, also lead to a phage titer fall. This review describes various formulations that impart stability to phage stocks, mainly focusing on polymer-based stabilization, encapsulation, lyophilization, and nano-assisted solutions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available