Journal
PHARMACEUTICS
Volume 14, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/pharmaceutics14112355
Keywords
biofilms; Enterococcus faecalis; trans-cinnamaldehyde; acidic sophorolipid
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Funding
- Discipline of Endodontics, Division of Restorative Dental Sciences, Faculty of Dentistry, The University of Hong Kong
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Enterococcus faecalis is a common opportunistic pathogen with high antibiotic tolerance and biofilm-forming ability. Combining trans-cinnamaldehyde with an FDA-approved biosurfactant significantly reduces bacterial viability and biomass of E. faecalis biofilms. This study highlights the potential of the newly developed TC-ASL complex as an anti-biofilm strategy.
Enterococcus faecalis is an opportunistic microbial pathogen frequently associated with diverse infections, including those of the skin and teeth, as well as those from surgical wounds. It forms robust biofilms that are highly tolerant to most antimicrobials and first-line antibiotics. Therefore, investigating alternative strategies to eradicate its biofilms is a critical need. We recently demonstrated that trans-cinnamaldehyde (TC) potently kills E. faecalis biofilm cells and prevents biofilm recovery, and yet, the extreme hydrophobicity of TC hampers clinical translation. Here, we report that a complex of TC with an FDA-approved biosurfactant (acidic sophorolipid/ASL) significantly reduces the bacterial viability and biomass of E. faecalis biofilms, compared to TC alone. A confocal laser-scanning microscopic analysis demonstrated that the TC-ASL treatment significantly decreased the biofilm thickness and volume. In conclusion, our study highlights the anti-biofilm potential of the newly developed TC-ASL.
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