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Role of hypoxia in the tumor microenvironment and targeted therapy

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UHRF1 promotes aerobic glycolysis and proliferation via suppression of SIRT4 in pancreatic cancer

Qiangsheng Hu et al.

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Hexokinase-II Inhibition Synergistically Augments the Anti-tumor Efficacy of Sorafenib in Hepatocellular Carcinoma

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Reactive oxygen species: a volatile driver of field cancerization and metastasis

Zehuan Liao et al.

MOLECULAR CANCER (2019)

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Macrophages and Metabolism in the Tumor Microenvironment

Ilio Vitale et al.

CELL METABOLISM (2019)

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EGFR-Pak Signaling Selectively Regulates Glutamine Deprivation-Induced Macropinocytosis

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Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming

Raquel Buj et al.

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Reactive Oxygen Species in the Tumor Microenvironment: An Overview

Frank Weinberg et al.

CANCERS (2019)

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Improving Cancer Immunotherapy by Targeting the Hypoxic Tumor Microenvironment: New Opportunities and Challenges

Muhammad Zaeem Noman et al.

CELLS (2019)

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Branched-chain amino acids sustain pancreatic cancer growth by regulating lipid metabolism

Ji Hyeon Lee et al.

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Lipid signalling drives proteolytic rewiring of mitochondria by YME1L

Thomas MacVicar et al.

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YAP Inhibition by Nuciferine via AMPK-Mediated Downregulation of HMGCR Sensitizes Pancreatic Cancer Cells to Gemcitabine

Ling Zhou et al.

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Dysregulation of glutaminase and glutamine synthetase in cancer

Jose M. Mates et al.

CANCER LETTERS (2019)

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Hypoxia as a barrier to immunotherapy in pancreatic adenocarcinoma

S. K. Daniel et al.

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BCL-2 proteins and apoptosis: Recent insights and unknowns

Frank Edlich

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Metabolic adaptation of cancer and immune cells mediated by hypoxia-inducible factors

Debangshu Samanta et al.

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Oxidative Phosphorylation as an Emerging Target in Cancer Therapy

Thomas M. Ashton et al.

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Chemotherapy induces enrichment of CD47+/CD73+/PDL1+ immune evasive triple-negative breast cancer cells

Debangshu Samanta et al.

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Antibody-mediated inhibition of MICA and MICB shedding promotes NK cell-driven tumor immunity

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A rationally designed NRP1-independent superagonist SEMA3A mutant is an effective anticancer agent

Noemi Gioelli et al.

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Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease

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Evidence-based complementary treatment of pancreatic cancer: a review of adjunct therapies including paricalcitol, hydroxychloroquine, intravenous vitamin C, statins, metformin, curcumin, and aspirin

Stephen Bigelsen

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Targeting adenosine for cancer immunotherapy

Robert D. Leone et al.

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Hypoxia and IF1 Expression Promote ROS Decrease in Cancer Cells

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Metabolic Stress in the Immune Function of T Cells, Macrophages and Dendritic Cells

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A Paradigm Shift in Cancer Immunotherapy: From Enhancement to Normalization

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Targeted hypoxia reduction restores T cell infiltration and sensitizes prostate cancer to immunotherapy

Priyamvada Jayaprakash et al.

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Lipid metabolism reprogramming and its potential targets in cancer

Chunming Cheng et al.

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B-Cell Metabolic Remodeling and Cancer

Davide G. Franchina et al.

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Hypoxic stress: obstacles and opportunities for innovative immunotherapy of cancer

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Design, synthesis, and evaluation of benzofuran derivatives as novel anti-pancreatic carcinoma agents via interfering the hypoxia environment by targeting HIF-1α pathway

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Hypoxia and B cells

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Reactive oxygen species and cancer paradox: To promote or to suppress?

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Reprogramming of the Tumor in the Hypoxic Niche: The Emerging Concept and Associated Therapeutic Strategies

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Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma

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Hypoxic Modulation of HLA-G Expression through the Metabolic Sensor HIF-1 in Human Cancer Cells

Marica Garziera et al.

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Pancreatic cancer cell/fibroblast co-culture induces M2 like macrophages that influence therapeutic response in a 3D model

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BCL2: A promising cancer therapeutic target

Gudapureddy Radha et al.

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Cancer cell metabolism: the essential role of the nonessential amino acid, glutamine

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Employing Metabolism to Improve the Diagnosis and Treatment of Pancreatic Cancer

Christopher J. Habrook et al.

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Metabolic changes associated with tumor metastasis, part 1: tumor pH, glycolysis and the pentose phosphate pathway

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Tumor-associated macrophages: Potential therapeutic targets for anti-cancer therapy

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Metabolic phenotype of bladder cancer

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α-Solanine inhibits vascular endothelial growth factor expression by down-regulating the ERK1/2-HIF-1α and STAT3 signaling pathways

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TGF-β Signaling in Cancer

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PKM2 promotes tumor angiogenesis by regulating HIF-1α through NF-κB activation

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The pancreatic niche inhibits the effectiveness of sunitinib treatment of pancreatic cancer

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Mitochondrial DNA copy number variation across human cancers

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Hypoxia and antitumor CD8+ T cells: An incompatible alliance?

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Overcoming Hypoxia-Mediated Tumor Progression:Combinatorial Approaches Targeting pH Regulation,Angiogenesis and Immune Dysfunction

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Hypoxia: a key player in antitumor immune response. A Review in the Theme: Cellular Responses to Hypoxia

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Efficacy and safety of the hypoxia-activated prodrug TH-302 in combination with gemcitabine and nab-paclitaxel in human tumor xenograft models of pancreatic cancer

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Oncotropic H-1 parvovirus infection degrades HIF-1α protein in human pancreatic cancer cells independently of VHL and RACK1

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Randomized Phase II Trial of Gemcitabine Plus TH-302 Versus Gemcitabine in Patients With Advanced Pancreatic Cancer

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Immune Response Regulation in the Tumor Microenvironment by Hypoxia

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Critical role of tumor microenvironment in shaping NK cell functions: implication of hypoxic stress

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Availability of the key metabolic substrates dictates the respiratory response of cancer cells to the mitochondrial uncoupling

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Antiangiogenesis Strategies Revisited: From Starving Tumors to Alleviating Hypoxia

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A Mechanism of Hypoxia-Mediated Escape from Adaptive Immunity in Cancer Cells

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Hypoxic Regulation of Glutamine Metabolism through HIF1 and SIAH2 Supports Lipid Synthesis that Is Necessary for Tumor Growth

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Systemic Delivery of Microencapsulated 3-Bromopyruvate for the Therapy of Pancreatic Cancer

Julius Chapiro et al.

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PD-L1 is a novel direct target of HIF-1α., and its blockade under hypoxia enhanced MDSC-mediated T cell activation

Muhammad Zaeem Noman et al.

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Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

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Cancer-associated fibroblasts and M2-polarized macrophages synergize during prostate carcinoma progression

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DNA Mismatch Repair and Oxidative DNA Damage: Implications for Cancer Biology and Treatment

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Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology

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Annual Review of Pathology-Mechanisms of Disease (2013)

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Molecular Pathways: Human Leukocyte Antigen G (HLA-G)

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Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response

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Hyper-O-GlcNAcylation Is Anti-apoptotic and Maintains Constitutive NF-κB Activity in Pancreatic Cancer Cells

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Influence of tumour micro-environment heterogeneity on therapeutic response

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Microenvironmental regulation of tumor progression and metastasis

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Intratumor Hypoxia Promotes Immune Tolerance by Inducing Regulatory T Cells via TGF-β1 in Gastric Cancer

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Characterization of oxygen radical formation mechanism at early cardiac ischemia

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Oxidative stress in apoptosis and cancer: an update

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HIF-1α is a negative regulator of plasmacytoid DC development in vitro and in vivo

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Synergy between PI3K Signaling and MYC in Burkitt Lymphomagenesis

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Hepatocellular carcinoma-associated fibroblasts trigger NK cell dysfunction via PGE2 and IDO

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The novel hypoxic cytotoxin, TX-2098 has antitumor effect in pancreatic cancer; possible mechanism through inhibiting VEGF and hypoxia inducible factor-1α targeted gene expression

Kotaro Miyake et al.

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Implication of Tumor Microenvironment in Chemoresistance: Tumor-Associated Stromal Cells Protect Tumor Cells from Cell Death

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BML-275, an AMPK inhibitor, induces DNA damage, G2/M arrest and apoptosis in human pancreatic cancer cells

Hong-Quan Duong et al.

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Positron Emission Tomographic Scans in Lymphoma: Convention and Controversy

Stephen M. Ansell et al.

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Hyperbaric oxygen therapy and cancer-a review

Ingrid Moen et al.

TARGETED ONCOLOGY (2012)

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Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

Gregg L. Semenza

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Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells

Lisa S. Pike et al.

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Oxygenation inhibits ovarian tumor growth by downregulating STAT3 and cyclin-D1 expressions

Karuppaiyah Selvendiran et al.

CANCER BIOLOGY & THERAPY (2010)

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Hypoxia and Hypoxia-Inducible Factors: Master Regulators of Metastasis

Xin Lu et al.

CLINICAL CANCER RESEARCH (2010)

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Hypoxia-activated prodrugs in cancer therapy: progress to the clinic

William A. Denny

FUTURE ONCOLOGY (2010)

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Hypoxia skews dendritic cells to a T helper type 2-stimulating phenotype and promotes tumour cell migration by dendritic cell-derived osteopontin

Meixiang Yang et al.

IMMUNOLOGY (2009)

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Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Matthew G. Vander Heiden et al.

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Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis

Javier A. Menendez et al.

NATURE REVIEWS CANCER (2007)

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Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells

Mariia Yuneva et al.

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Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing

RD Guzy et al.

CELL METABOLISM (2005)

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Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy

RK Jain

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Duel nature of TGF-beta signaling: tumor suppressor vs. tumor promoter

KE Bachman et al.

CURRENT OPINION IN ONCOLOGY (2005)

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A critical role of glutathione in determining apoptosis sensitivity and resistance in leukemia cells

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CELL DEATH AND DIFFERENTIATION (2004)

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