Transcranial versus direct electrical stimulation for intraoperative motor-evoked potential monitoring: Prognostic value comparison in asleep brain tumor surgery

Article Clinical Neurology

Asleep or awake motor mapping for resection of perirolandic glioma in the nondominant hemisphere? Development and validation of a multimodal score to tailor the surgical strategy

Marco Rossi et al.

Summary: This study aims to identify factors that influence surgical strategy and outcomes in glioma resection and design a mapping score for guiding tumor resection.

JOURNAL OF NEUROSURGERY (2022)

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Article Oncology

Association of supratotal resection with progression-free survival, malignant transformation, and overall survival in lower-grade gliomas

Marco Rossi et al.

Summary: The study found that supratotal resection is strongly associated with good oncological outcomes in molecularly defined lower-grade gliomas, regardless of molecular subtypes and grading.

NEURO-ONCOLOGY (2021)

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Article Oncology

EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood

Michael Weller et al.

Summary: The European Association of Neuro-Oncology (EANO) has released guidelines for the diagnosis, treatment, and follow-up of adult patients with diffuse gliomas, incorporating major changes in diagnostic algorithms based on the 2016 update of the WHO Classification of Tumors of the Central Nervous System, as well as evidence from recent large clinical trials.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

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Article Clinical Neurology

Clinical Pearls and Methods for Intraoperative Motor Mapping

Marco Rossi et al.

Summary: Resection of brain tumors involving motor areas and pathways requires the identification and preservation of various cortical and subcortical structures involved in motor control at the time of the procedure, in order to maintain the patient's full motor capacities. The use of brain mapping techniques has now been integrated into clinical practice for many years, as they help the surgeon to identify the neural structures involved in motor functions.

NEUROSURGERY (2021)

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Article Behavioral Sciences

Negative motor responses to direct electrical stimulation: Behavioral assessment hides different effects on muscles

Luca Vigano et al.

Summary: The study shows that behavioral assessment of NMRs may hide different site-dependent effects on muscles, which can be distinguished using electromyography. The EMG monitoring paired with behavioral assessment can differentiate between NMRs that are similar on behavioral inspection but have different related EMG patterns.

CORTEX (2021)

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Article Oncology

Challenging Giant Insular Gliomas With Brain Mapping: Evaluation of Neurosurgical, Neurological, Neuropsychological, and Quality of Life Results in a Large Mono-Institutional Series

Marco Rossi et al.

Summary: In the study, the transcortical approach with extensive brain mapping under awake anesthesia ensured broad insular exposure and extension of the surgical resection while preserving patients' functional integrity. The relationship between tumor mass and deep perforators predicted perioperative ischemic insults, which were the most relevant risk factor for long-term and permanent postoperative morbidity.

FRONTIERS IN ONCOLOGY (2021)

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Article Oncology

Factors Influencing Mood Disorders and Health Related Quality of Life in Adults With Glioma: A Longitudinal Study

Antonella Leonetti et al.

Summary: The prevalence of Mood Disorders (MD) and decline in Health Related Quality of Life (HRQoL) in glioma patients may be associated with tumor features or treatment-related symptoms. Factors associated with MD and low HRQoL vary in lower-grade gliomas (LGGs) and higher-grade gliomas (HGGs) over the course of the disease.

FRONTIERS IN ONCOLOGY (2021)

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Article Oncology

Targeting Primary Motor Cortex (M1) Functional Components in M1 Gliomas Enhances Safe Resection and Reveals M1 Plasticity Potentials

Marco Rossi et al.

Summary: The study highlights the novel technique for on-line identification of two functional components in the Primary-Motor-Cortex (M1) during tumor resection, showing the potential plasticity reorganization of M1 and its impact on tumor resection and patient motor performance. By detecting and targeting these components, complete tumor removal rate can be increased while maintaining motor function, suggesting M1 plasticity potentials.

CANCERS (2021)

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Review Oncology

Motor Evoked Potential Warning Criteria in Supratentorial Surgery: A Scoping Review

Evridiki Asimakidou et al.

Summary: Motor evoked potential (MEP) alarm criteria play a crucial role in preserving motor function during supratentorial neurosurgical procedures. The existing literature lacks consensus on optimal cut-off values and interpretation of MEP signal changes. Further research is needed to establish consensus on definitions of MEP alterations, critical duration of alterations, and outcome reporting.

CANCERS (2021)

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Article Clinical Neurology

Long-term motor deficit in brain tumour surgery with preserved intra-operative motor-evoked potentials

Davide Giampiccolo et al.

Summary: Monitoring muscle motor-evoked potentials during brain tumour surgery can help identify potential motor deficits, but deficits unrelated to changes in these potentials can still occur, especially after surgery in non-primary motor areas. Long-term motor deficits are often associated with damage to the corticospinal tract, while deficits unrelated to muscle motor-evoked potentials can occur when other motor regions are impacted during surgery. New techniques beyond muscle motor-evoked potentials monitoring may be needed to predict and prevent such deficits.

BRAIN COMMUNICATIONS (2021)

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Review Clinical Neurology