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Emerging roles of ferroptosis in glioma

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CURRENT PHARMACEUTICAL DESIGN (2020)

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Article Medicine, Research & Experimental

Significance of tumor protein p53 mutation in cellular process and drug selection in brain lower grade (WHO grades II and III) glioma

Chang-Feng Guo et al.

BIOMARKERS IN MEDICINE (2020)

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Inhibition of lncRNA LINC00461/miR-216a/aquaporin 4 pathway suppresses cell proliferation, migration, invasion, and chemoresistance in glioma

Yanguo Peng et al.

OPEN LIFE SCIENCES (2020)

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Miltirone induces cell death in hepatocellular carcinoma cell through GSDME-dependent pyroptosis

Xiaowei Zhang et al.

ACTA PHARMACEUTICA SINICA B (2020)

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Article Cell Biology

Ferroptosis-Related Gene Signature Predicts Glioma Cell Death and Glioma Patient Progression

Han-jie Liu et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Article Oncology

Hypoxia induced ferritin light chain (FTL) promoted epithelia mesenchymal transition and chemoresistance of glioma

Junhui Liu et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

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Review Chemistry, Medicinal

Autophagy as a Potential Therapy for Malignant Glioma

Angel Escamilla-Ramirez et al.

PHARMACEUTICALS (2020)

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Ferroptosis, necroptosis, and pyroptosis in anticancer immunity

Rong Tang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

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Targeting tumor hypoxia and mitochondrial metabolism with anti-parasitic drugs to improve radiation response in high-grade gliomas

Faiqa Mudassar et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

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Autophagy activated by silibinin contributes to glioma cell death via induction of oxidative stress-mediated BNIP3-dependent nuclear translocation of AIF

Chongcheng Wang et al.

CELL DEATH & DISEASE (2020)

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Review Cell Biology

Iron Metabolism in Ferroptosis

Xin Chen et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Review Biology

A Glance of p53 Functions in Brain Development, Neural Stem Cells, and Brain Cancer

Yuqing Xiong et al.

BIOLOGY-BASEL (2020)

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Article Cell Biology

Circ_0005198 enhances temozolomide resistance of glioma cells through miR-198/TRIM14 axis

Yanyao Deng et al.

Aging-US (2020)

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Article Cell Biology

Ionizing radiation results in a mixture of cellular outcomes including mitotic catastrophe, senescence, methuosis, and iron-dependent cell death

Sandy Adjemian et al.

CELL DEATH & DISEASE (2020)

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Review Immunology

Glioma progression and recurrence involving maintenance and expansion strategies of glioma stem cells by organizing self-advantageous niche microenvironments

Tetsuya Taga et al.

INFLAMMATION AND REGENERATION (2020)

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MGMT Status as a Clinical Biomarker in Glioblastoma

Madison Butler et al.

TRENDS IN CANCER (2020)

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Review Biochemistry & Molecular Biology

DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer

Rui-Xue Huang et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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High LC3/Beclin Expression Correlates with Poor Survival in Glioma: a Definitive Role for Autophagy as Evidenced by In Vitro Autophagic Flux

C. J. Padmakrishnan et al.

PATHOLOGY & ONCOLOGY RESEARCH (2019)

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Review Biochemistry & Molecular Biology

The development of the concept of ferroptosis

Tal Hirschhorn et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

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Quantitative characterization of the regulation of iron metabolism in glioblastoma stem-like cells using magnetophoresis

Kyoung-Joo J. Park et al.

BIOTECHNOLOGY AND BIOENGINEERING (2019)

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Cellular and molecular mechanisms of glioblastoma malignancy: Implications in resistance and therapeutic strategies

Joana Balca-Silva et al.

SEMINARS IN CANCER BIOLOGY (2019)

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Ferroptosis, a new form of cell death: opportunities and challenges in cancer

Yanhua Mou et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

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Article Multidisciplinary Sciences

Radiotherapy resistance acquisition in Glioblastoma. Role of SOCS1 and SOCS3

Maria Paz Ventero et al.

PLOS ONE (2019)

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EMT Regulation by Autophagy: A New Perspective in Glioblastoma Biology

Barbara Colella et al.

CANCERS (2019)

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Temozolomide Induced Hypermutation in Glioma: Evolutionary Mechanisms and Therapeutic Opportunities

Paul Daniel et al.

FRONTIERS IN ONCOLOGY (2019)

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Article Multidisciplinary Sciences

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

Weimin Wang et al.

NATURE (2019)

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Nanotechnology Meets Oncology: Nanomaterials in Brain Cancer Research, Diagnosis and Therapy

Alja Zottel et al.

MATERIALS (2019)

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Novel analogs of sulfasalazine as system xc- antiporter inhibitors: Insights from the molecular modeling studies

Dhavalkumar Patel et al.

DRUG DEVELOPMENT RESEARCH (2019)

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Mechanisms of immunotherapy resistance: lessons from glioblastoma

Christopher M. Jackson et al.

NATURE IMMUNOLOGY (2019)

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Review Biochemistry & Molecular Biology

The role of pyroptosis in gastrointestinal cancer and immune responses to intestinal microbial infection

Cheng-Bei Zhou et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2019)

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Article Cell Biology

Lysosomal Destabilizing Drug Siramesine and the Dual Tyrosine Kinase Inhibitor Lapatinib Induce a Synergistic Ferroptosis through Reduced Heme Oxygenase-1 (HO-1) Levels

Gloria E. Villalpando-Rodriguez et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

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Article Multidisciplinary Sciences

Mechanism of activation of the human cysteine desulfurase complex by frataxin

Shachin Patra et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Article Oncology

Radiotherapy and Immunotherapy Promote Tumoral Lipid Oxidation and Ferroptosis via Synergistic Repression of SLC7A11

Xueting Lang et al.

CANCER DISCOVERY (2019)

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Review Medicine, Research & Experimental

Chemoresistance caused by the microenvironment of glioblastoma and the corresponding solutions

Xin Zhang et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Review Biochemistry & Molecular Biology

Autophagy-dependent cell death

Donna Denton et al.

CELL DEATH AND DIFFERENTIATION (2019)

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Review Clinical Neurology

Aberrant Transcriptional Regulation of Super-enhancers by RET Finger Protein-histone Deacetylase 1 Complex in Glioblastoma: Chemoresistance to Temozolomide

Atsushi Natsume et al.

NEUROLOGIA MEDICO-CHIRURGICA (2019)

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Review Medicine, General & Internal

Hypoxia Imaging and Adaptive Radiotherapy: A State-of-the-Art Approach in the Management of Glioma

Michael Gerard et al.

FRONTIERS IN MEDICINE (2019)

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Article Biochemistry & Molecular Biology

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

Irina Ingold et al.

CELL (2018)

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Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis

Rui Kang et al.

CELL HOST & MICROBE (2018)

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Molecular characterization and functional analysis of two phospholipid hydroperoxide isoforms from Larimichthys crocea under Vibrio parahaemolyticus challenge

Xiaoze Xie et al.

FISH & SHELLFISH IMMUNOLOGY (2018)

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Article Oncology

High expression of cystine-glutamate antiporter xCT (SLC7A11) is an independent biomarker for epileptic seizures at diagnosis in glioma

Mai Froberg Sorensen et al.

JOURNAL OF NEURO-ONCOLOGY (2018)

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Article Neurosciences

Combination Therapy with Sulfasalazine and Valproic Acid Promotes Human Glioblastoma Cell Death Through Imbalance of the Intracellular Oxidative Response

Carlos Gustavo Garcia et al.

MOLECULAR NEUROBIOLOGY (2018)

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Review Pharmacology & Pharmacy

The Role of Ferroptosis in Cancer Development and Treatment Response

Bin Lu et al.

FRONTIERS IN PHARMACOLOGY (2018)

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The p53 Tumor Suppressor in the Control of Metabolism and Ferroptosis

Keerthana Gnanapradeepan et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

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Editorial Material Cell Biology

BECN1 is a new driver of ferroptosis

Rui Kang et al.

AUTOPHAGY (2018)

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Article Biochemistry & Molecular Biology

AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc- Activity

Xinxin Song et al.

CURRENT BIOLOGY (2018)

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Glioblastoma Chemoresistance: The Double Play by Microenvironment and Blood-Brain Barrier

Martina Da Ros et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Potential Strategies Overcoming the Temozolomide Resistance for Glioblastoma

Shabierjiang Jiapaer et al.

NEUROLOGIA MEDICO-CHIRURGICA (2018)

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Article Cell Biology

Inhibition of autophagy increases susceptibility of glioblastoma stem cells to temozolomide by igniting ferroptosis

Mariachiara Buccarelli et al.

CELL DEATH & DISEASE (2018)

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The p53 Pathway in Glioblastoma

Ying Zhang et al.

CANCERS (2018)

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Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

Valerian E. Kagan et al.

NATURE CHEMICAL BIOLOGY (2017)

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Article Biochemistry & Molecular Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

Sebastian Doll et al.

NATURE CHEMICAL BIOLOGY (2017)

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Evolution of Neoantigen Landscape during Immune Checkpoint Blockade in Non-Small Cell Lung Cancer

Valsamo Anagnostou et al.

CANCER DISCOVERY (2017)

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Reactive oxygen species and cancer paradox: To promote or to suppress?

Sehamuddin Galadari et al.

FREE RADICAL BIOLOGY AND MEDICINE (2017)

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Article Biochemistry & Molecular Biology

Cystine uptake through the cystine/glutamate antiporter xCT triggers glioblastoma cell death under glucose deprivation

Takeo Goji et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

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Article Multidisciplinary Sciences

NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis

Samantha W. Alvarez et al.

NATURE (2017)

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Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

Matthew J. Hangauer et al.

NATURE (2017)

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ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner

D. Chen et al.

ONCOGENE (2017)

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FTY720 inhibits the Nrf2/ARE pathway in human glioblastoma cell lines and sensitizes glioblastoma cells to temozolomide

Li Zhang et al.

PHARMACOLOGICAL REPORTS (2017)

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Alpha-tocopherol inhibits pore formation in oxidized bilayers

Phansiri Boonnoy et al.

PHYSICAL CHEMISTRY CHEMICAL PHYSICS (2017)

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A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma

Donald M. O'Rourke et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

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SLC7A11 Overexpression in Glioblastoma Is Associated with Increased Cancer Stem Cell-Like Properties

Monika D. Polewski et al.

STEM CELLS AND DEVELOPMENT (2017)

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Targeting transferrin receptor delivery of temozolomide for a potential glioma stem cell-mediated therapy

Ting Sun et al.

ONCOTARGET (2017)

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The oxido-metabolic driver ATF4 enhances temozolamide chemo-resistance in human gliomas

Daishi Chen et al.

ONCOTARGET (2017)

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A molecular view of the radioresistance of gliomas

Xuetao Han et al.

ONCOTARGET (2017)

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The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

Yangchun Xie et al.

CELL REPORTS (2017)

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Targeted Nanotechnology in Glioblastoma Multiforme

Talita Glaser et al.

FRONTIERS IN PHARMACOLOGY (2017)

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SOCS1 regulates senescence and ferroptosis by modulating the expression of p53 target genes

Emmanuelle Saint-Germain et al.

AGING-US (2017)

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Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

Brent R. Stockwell et al.

CELL (2017)

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The movers and shapers in immune privilege of the CNS

Britta Engelhardt et al.

NATURE IMMUNOLOGY (2017)

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Lipid peroxidation in cell death

Michael M. Gaschler et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

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Autophagy promotes ferroptosis by degradation of ferritin

Wen Hou et al.

AUTOPHAGY (2016)

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Deferiprone Enhances Temozolomide Cytotoxicity in Glioma Cells

George A. Alexiou et al.

CANCER INVESTIGATION (2016)

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Sulfasalazine intensifies temozolomide cytotoxicity in human glioblastoma cells

Raffaela Silvestre Ignarro et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2016)

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Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses

Yang Ou et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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Article Multidisciplinary Sciences

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

Wan Seok Yang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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Article Multidisciplinary Sciences

Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints

Shohei Koyama et al.

NATURE COMMUNICATIONS (2016)

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Sulfasalazine impacts on ferroptotic cell death and alleviates the tumor microenvironment and glioma-induced brain edema

Tina Sehm et al.

ONCOTARGET (2016)

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NRF2 and glutathione are key resistance mediators to temozolomide in glioma and melanoma cells

Clarissa Ribeiro Reily Rocha et al.

ONCOTARGET (2016)

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Temozolomide resistance in glioblastoma multiforme

Sang Y. Lee

GENES & DISEASES (2016)

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Effects of Iron Ions and Iron Chelation on the Efficiency of Experimental Radiotherapy of Animals with Gliomas

S. D. Ivanov et al.

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2015)

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Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells

David L. Schonberg et al.

CANCER CELL (2015)

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The synergistic effect of combination temozolomide and chloroquine treatment is dependent on autophagy formation and p53 status in glioma cells

Seung Woo Lee et al.

CANCER LETTERS (2015)

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Transferrin receptors and glioblastoma multiforme: Current findings and potential for treatment

Brittany Voth et al.

JOURNAL OF CLINICAL NEUROSCIENCE (2015)

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Glutaminolysis and Transferrin Regulate Ferroptosis

Minghui Gao et al.

MOLECULAR CELL (2015)

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Drug repurposing: sulfasalazine sensitizes gliomas to gamma knife radiosurgery by blocking cystine uptake through system Xc-, leading to glutathione depletion

L. Sleire et al.

ONCOGENE (2015)

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Erastin sensitizes glioblastoma cells to temozolomide by restraining xCT and cystathionine-γ-lyase function

Liangyu Chen et al.

ONCOLOGY REPORTS (2015)

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SLC7A11 expression is associated with seizures and predicts poor survival in patients with malignant glioma

Stephanie M. Robert et al.

SCIENCE TRANSLATIONAL MEDICINE (2015)

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Iron metabolism: a double-edged sword in the resistance of glioblastoma to therapies

Claire Legendre et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2015)

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Epidemiologic and Molecular Prognostic Review of Glioblastoma

Jigisha P. Thakkar et al.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2014)

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Brain tumor stem cells: Molecular characteristics and their impact on therapy

David L. Schonberg et al.

MOLECULAR ASPECTS OF MEDICINE (2014)

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Nanotherapeutic approaches for brain cancer management

Laura Saenz del Burgo et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2014)

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Curcumin sensitizes glioblastoma to temozolomide by simultaneously generating ROS and disrupting AKT/mTOR signaling

Haitao Yin et al.

ONCOLOGY REPORTS (2014)

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NF-κB, an Active Player in Human Cancers

Yifeng Xia et al.

CANCER IMMUNOLOGY RESEARCH (2014)

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Glutathione synthesis

Shelly C. Lu

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2013)

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Molecular Pathways: Targeted α-Particle Radiation Therapy

Kwamena E. Baidoo et al.

CLINICAL CANCER RESEARCH (2013)

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Increased xCT Expression Correlates With Tumor Invasion and Outcome in Patients With Glioblastomas

Satoru Takeuchi et al.

NEUROSURGERY (2013)

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Knockdown of NF-E2-related factor 2 inhibits the proliferation and growth of U251MG human glioma cells in a mouse xenograft model

Xiang-Jun Ji et al.

ONCOLOGY REPORTS (2013)

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The transsulfuration pathway: a source of cysteine for glutathione in astrocytes

Gethin J. McBean

AMINO ACIDS (2012)

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Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury

Edouard I. Azzam et al.

CANCER LETTERS (2012)

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Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon et al.

CELL (2012)

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Sulfasalazine for brain cancer fits

Harald Sontheimer et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2012)

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Image-guided radiotherapy: from current concept to future perspectives

David A. Jaffray

NATURE REVIEWS CLINICAL ONCOLOGY (2012)

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The Beclin 1 network regulates autophagy and apoptosis

R. Kang et al.

CELL DEATH AND DIFFERENTIATION (2011)

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Bioenergetics Pathways and Therapeutic Resistance in Gliomas: Emerging Role of Mitochondria

Corinne E. Griguer et al.

CURRENT PHARMACEUTICAL DESIGN (2011)

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Dealing with methionine/homocysteine sulfur: cysteine metabolism to taurine and inorganic sulfur

Martha H. Stipanuk et al.

JOURNAL OF INHERITED METABOLIC DISEASE (2011)

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Review Clinical Neurology

Brain iron metabolism and its perturbation in neurological diseases

Robert R. Crichton et al.

JOURNAL OF NEURAL TRANSMISSION (2011)

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Editorial Material Clinical Neurology

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Silvia Mandel et al.

JOURNAL OF NEURAL TRANSMISSION (2011)

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Article Medicine, Research & Experimental

Dual role of the mitochondrial protein frataxin in astrocytic tumors

Elmar Kirches et al.

LABORATORY INVESTIGATION (2011)

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Review Biochemistry & Molecular Biology

Survival signalling and apoptosis resistance in glioblastomas: opportunities for targeted therapeutics

Camilla Krakstad et al.

MOLECULAR CANCER (2010)

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Article Multidisciplinary Sciences

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

Sawako Suzuki et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

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Article Oncology

Transferrin Receptor 2 Is Frequently and Highly Expressed in Glioblastomas

Alessia Calzolari et al.

TRANSLATIONAL ONCOLOGY (2010)

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Critical appraisal of temozolomide formulations in the treatment of primary brain tumors: patient considerations

Margarita García Martín et al.

Cancer Management and Research (2010)

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Article Biochemistry & Molecular Biology

Induction of glioma apoptosis by microglia-secreted molecules: The role of nitric oxide and cathepsin B

So-Young Hwang et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2009)

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Article Genetics & Heredity

Transferrin-receptor-mediated iron accumulation controls proliferation and glutamate release in glioma cells

S. R. Chirasani et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2009)

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Article Biochemistry & Molecular Biology

Intracellular labile iron

William Breuer et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2008)

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Article Oncology

Reciprocal regulation of SOCS1 and SOCS3 enhances resistance to ionizing radiation in glioblastoma multiforme

Hong Zhou et al.

CLINICAL CANCER RESEARCH (2007)

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Article Biochemistry & Molecular Biology

Malignant glioma progression and nitric oxide

Dora Lam-Himlin et al.

NEUROCHEMISTRY INTERNATIONAL (2006)

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Article Pharmacology & Pharmacy

Mechanistic studies of the Nrf2-Keap1 signaling pathway

Donna D. Zhang

DRUG METABOLISM REVIEWS (2006)

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Article Multidisciplinary Sciences

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

ZY Yue et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

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