4.6 Review

Emerging roles of ferroptosis in glioma

Journal

FRONTIERS IN ONCOLOGY
Volume 12, Issue -, Pages -

Publisher

FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2022.993316

Keywords

ferroptosis; glioma; programmed cell death; iron metabolism; therapy resistance

Categories

Funding

  1. Natural Science Foundation of China [81803045, 82103277]
  2. China Postdoctoral Science Foundation [2020M672072]
  3. Research Project of Jinan Microecological Biomedicine Shandong Laboratory [JNL2022041C]
  4. Shandong Excellent Young Scientists Fund Program [2022HWYQ-035]
  5. Shandong Provincial Natural Science Foundation [ZR2021QH030]
  6. Qilu Young Scholar Program of Shandong University, China

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This review provides an overview of the characteristics, key regulators, and pathways of ferroptosis in glioma treatment. The crosstalk between ferroptosis and other programmed cell death in glioma is also discussed, along with the potential application and prospects of ferroptosis as a target for glioma treatment.
Glioma is the most common primary malignant tumor in the central nervous system, and directly affects the quality of life and cognitive function of patients. Ferroptosis, is a new form of regulated cell death characterized by iron-dependent lipid peroxidation. Ferroptosis is mainly due to redox imbalance and involves multiple intracellular biology processes, such as iron metabolism, lipid metabolism, and antioxidants synthesis. Induction of ferroptosis could be a new target for glioma treatment, and ferroptosis-related processes are associated with chemoresistance and radioresistance in glioma. In the present review, we provide the characteristics, key regulators and pathways of ferroptosis and the crosstalk between ferroptosis and other programmed cell death in glioma, we also proposed the application and prospect of ferroptosis in the treatment of glioma.

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