Journal
FRONTIERS IN ONCOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2022.947634
Keywords
CNS; cancer stem cells (CSC); glioblastoma; GBM; CSC
Categories
Funding
- NIH
- NIH, National Cancer Institute, Center for Cancer Research
Ask authors/readers for more resources
This article reviews the development mechanisms of the cancer stem cell niche, with a focus on glioblastoma. By studying nonmalignant stem cell niches, important parallels can be drawn to the malignant environment. Understanding the cancer stem cell niche may provide new insights for therapeutic approaches.
Cancer stem cells are thought to be the main drivers of tumorigenesis for malignancies such as glioblastoma (GBM). They are maintained through a close relationship with the tumor vasculature. Previous literature has well-characterized the components and signaling pathways for maintenance of this stem cell niche, but details on how the niche initially forms are limited. This review discusses development of the nonmalignant neural and hematopoietic stem cell niches in order to draw important parallels to the malignant environment. We then discuss what is known about the cancer stem cell niche, its relationship with angiogenesis, and provide a hypothesis for its development in GBM. A better understanding of the mechanisms of development of the tumor stem cell niche may provide new insights to potentially therapeutically exploit.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available