Journal
FRONTIERS IN ONCOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2022.1008361
Keywords
lipid metabolism reprogramming; lipid catabolism; lipid synthesis; lipid uptake; HNSCCs
Categories
Funding
- Cultivation Project of the Major Research Plan of the National Natural Science Foundation of China
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality
- Shanghai Sailing Program
- Ruijin Youth NSFC Cultivation Fund
- [91949119]
- [82101209]
- [82101212]
- [21ZR1440200]
- [20YF1426400]
- [19YF1430300]
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The role of lipid metabolism reprogramming in HNSCCs is not yet fully understood. This review summarizes its crucial cellular signaling roles in tumorigenicity and malignancy, and discusses the differences between different regions of HNSCCs caused by anatomical heterogeneity.
Recent studies showed that lipid metabolism reprogramming contributes to tumorigenicity and malignancy by interfering energy production, membrane formation, and signal transduction in cancers. HNSCCs are highly reliant on aerobic glycolysis and glutamine metabolism. However, the mechanisms underlying lipid metabolism reprogramming in HNSCCs remains obscure. The present review summarizes and discusses the vital cellular signaling roles of the lipid metabolism reprogramming in HNSCCs. We also address the differences between HNSCCs regions caused by anatomical heterogeneity. We enumerate these recent findings into our current understanding of lipid metabolism reprogramming in HNSCCs and introduce the new and exciting therapeutic implications of targeting the lipid metabolism.
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