Journal
CELLS
Volume 11, Issue 17, Pages -Publisher
MDPI
DOI: 10.3390/cells11172709
Keywords
temporomandibular joint; temporomandibular disorders; intra articular injection; mesenchymal stem cells; stem cell transplantation
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This systematic review analyzed the outcomes of intra-articular administration of mesenchymal stem cells (MSCs) for the treatment of temporomandibular joint (TMJ) articular pain (AP) and restricted maximum mouth opening (MMO). The results suggest that intra-articular administration of MSCs may be highly effective in reducing AP and improving MMO.
This systematic review aims to analyze the outcomes of the treatment of temporomandibular joint (TMJ) articular pain (AP) and restricted maximum mouth opening (MMO) with intra-articular administration of mesenchymal stem cells (MSCs). The inclusion criteria allowed primary studies involving AP and/or MMO pre-treatment and post-intervention values. Medical databases that were covered by ACM Digital, BASE, EBSCOhost, Google Scholar, PubMed, Scopus, and Web of Science engines were searched. The risk of bias was assessed with RoB 2 and ROBINS-I tools. The results were tabulated, plotted, and analyzed for regression. A total of 5 studies involving 51 patients/69 TMJs were identified, and 4 studies on 50 patients/67 TMJs were synthesized. Interventions were each time effective in decreasing AP and increasing MMO in a 6-month follow-up period by an average of about 85% and over 40%, respectively. Regression analysis showed a good fit of the logarithmic model for AP relief (5.8 - 0.8 ln x; R-2 = 0.90) and MMO increase (33.5 + 2.4 ln x; R-2 = 0.89). The results for AP and MMO were based on 3 studies in 39 patients and 4 studies in 50 patients, respectively, all at high risk of bias. The intra-articular administration of MSCs to TMJs, based on weak evidence, may be highly effective in reducing AP and improving MMO. This study received no funding.
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