Journal
CELLS
Volume 11, Issue 16, Pages -Publisher
MDPI
DOI: 10.3390/cells11162576
Keywords
atria; atrial myocardium; atrial cardiomyopathy; tobacco; cigarettes; smoking; alcohol; drinking
Categories
Funding
- Health Research Foundation of Central Denmark Region
- European Research Council (ERC) under the European Union [648131]
- European Union [847770]
- German Center for Cardiovascular Research (DZHK e.V.) [81Z1710103, 81Z0710114]
- German Ministry of Research and Education [BMBF 01ZX1408A]
- ERACo-SysMed3 [031L0239]
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Tobacco smoking and alcohol consumption are common and socially accepted, but they are also important risk factors for cardiovascular diseases, particularly atrial fibrillation and stroke. The alterations in atrial myocardium associated with smoking and alcohol involve complex mechanisms and factors, including pathophysiology, environment, and society.
Tobacco smoking and alcohol consumption are widespread exposures that are legal and socially accepted in many societies. Both have been widely recognized as important risk factors for diseases in all vital organ systems including cardiovascular diseases, and with clinical manifestations that are associated with atrial dysfunction, so-called atrial cardiomyopathy, especially atrial fibrillation and stroke. The pathogenesis of atrial cardiomyopathy, atrial fibrillation, and stroke in context with smoking and alcohol consumption is complex and multifactorial, involving pathophysiological mechanisms, environmental, and societal aspects. This narrative review summarizes the current literature regarding alterations in the atrial myocardium that is associated with smoking and alcohol.
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