4.6 Review

The Interplay between the Cellular Response to DNA Double-Strand Breaks and Estrogen

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

Homologous Recombination Deficiencies and Hereditary Tumors

Hideki Yamamoto et al.

Summary: Homologous recombination (HR) is a crucial process for repairing DNA double-strand breaks and is associated with inherited susceptibility to specific types of cancers. Variants in different genes within the HR pathway have varying effects, but the protein products of these genes are essential for maintaining a high-fidelity DNA repair system by HR.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Biotechnology & Applied Microbiology

Crosstalk between different DNA repair pathways for DNA double strand break repairs

Jung-Min Oh et al.

Summary: DNA double strand breaks (DSBs) are repaired by different pathways, including non-homologous end joining (NHEJ), homologous recombination (HR), single strand annealing (SSA) and alternative end joining (alt-EJ). The choice of repair pathway depends on the cell cycle phase and the length of the broken DNA. NHEJ repairs blunt and short regions of the DNA, while HR, SSA, and alt-EJ use resected DNA.

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2022)

Article Oncology

Heterozygotic Brca1 mutation initiates mouse genome instability at embryonic stage

Xiaobing Wu et al.

Summary: The study reveals that BRCA1 mutation can cause genome instability at the embryonic stage, and the instability level dynamically changes throughout the developmental process.

ONCOGENESIS (2022)

Review Biochemistry & Molecular Biology

Deregulated estrogen receptor signaling and DNA damage response in breast tumorigenesis

Arathi Rajan et al.

Summary: Individuals with BRCA1 mutations are more prone to developing cancers in hormone-responsive tissues, which do not respond well to hormone therapy and exhibit increased DNA damages. There is a cross regulatory signaling network between ER-alpha and BRCA1, and understanding this interaction is crucial for drug development and therapy for breast/ovarian cancers.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2021)

Review Genetics & Heredity

ATM's Role in the Repair of DNA Double-Strand Breaks

Atsushi Shibata et al.

Summary: ATM is a central kinase that activates a wide range of responses to cellular stress through signaling. It plays multiple roles in response to DNA damage, particularly focusing on DSB repair. Dysfunction in stress responses impairs repair accuracy, leading to dramatic sensitivity to ionizing radiation in ataxia telangiectasia (A-T) cells.

GENES (2021)

Review Oncology

CBP/p300: Critical Co-Activators for Nuclear Steroid Hormone Receptors and Emerging Therapeutic Targets in Prostate and Breast Cancers

Aaron R. Waddell et al.

Summary: CBP and p300 are paralogous lysine acetyltransferases that play critical roles in regulating transcription factors in cancer signaling pathways. They have been established as important regulators of nuclear hormone signaling, such as androgen receptor (AR) and estrogen receptor (ER), which are associated with tumor growth in hormone-dependent prostate and breast cancers. Inhibitors targeting CBP and p300 show potential as a novel therapeutic strategy for prostate and breast cancers by blocking AR and ER transactivation activity.

CANCERS (2021)

Review Biochemistry & Molecular Biology

Estrogen Receptors and Ubiquitin Proteasome System: Mutual Regulation

Irina Kondakova et al.

BIOMOLECULES (2020)

Review Biochemistry & Molecular Biology

R-Loops as Cellular Regulators and Genomic Threats

Madzia P. Crossley et al.

MOLECULAR CELL (2019)

Review Cell Biology

DNA double-strand break repair-pathway choice in somatic mammalian cells

Ralph Scully et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Review Oncology

Harnessing DNA Double-Strand Break Repair for Cancer Treatment

Anika Trenner et al.

FRONTIERS IN ONCOLOGY (2019)

Review Biochemistry & Molecular Biology

The Functions of DNA Damage Factor RNF8 in the Pathogenesis and Progression of Cancer

Tingting Zhou et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2019)

Article Cell Biology

RNF168 facilitates oestrogen receptor α transcription and drives breast cancer proliferation

Zhenhua Liu et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2018)

Article Biochemistry & Molecular Biology

Estrogen matters in metastasis

Shardool Nair et al.

STEROIDS (2018)

Review Oncology

Estrogen Effects on the Mammary Gland in Early and Late Life and Breast Cancer Risk

Genevieve Victoria Dall et al.

FRONTIERS IN ONCOLOGY (2017)

Article Biochemistry & Molecular Biology

RNF8 identified as a co-activator of estrogen receptor α promotes cell growth in breast cancer

Shengli Wang et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2017)

Article Biochemistry & Molecular Biology

MDC1 Enhances Estrogen Receptor-mediated Transactivation and Contributes to Breast Cancer Suppression

Renlong Zou et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2015)

Article Cell Biology

Homologous Recombination and Human Health: The Roles of BRCA1, BRCA2, and Associated Proteins

Rohit Prakash et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2015)

Article Oncology

Cyclin D1 Integrates Estrogen-Mediated DNA Damage Repair Signaling

Zhiping Li et al.

CANCER RESEARCH (2014)

Review Biochemistry & Molecular Biology

BRCA1 And Estrogen/Estrogen Receptor In Breast Cancer: Where They Interact?

Li Wang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2014)

Review Physiology

Estrogen and Cancer

Jing Liang et al.

ANNUAL REVIEW OF PHYSIOLOGY, VOL 75 (2013)

Review Biochemistry & Molecular Biology

Forkhead Box(O) in Control of Reactive Oxygen Species and Genomic Stability to Ensure Healthy Lifespan

Paraskevi Charitou et al.

ANTIOXIDANTS & REDOX SIGNALING (2013)

Review Biochemistry & Molecular Biology

DNA-Damaging Agents in Cancer Chemotherapy: Serendipity and Chemical Biology

Kahlin Cheung-Ong et al.

CHEMISTRY & BIOLOGY (2013)

Article Oncology

Estrogen Receptor α Regulates ATM Expression through miRNAs in Breast Cancer

Xiaojing Guo et al.

CLINICAL CANCER RESEARCH (2013)

Article Cell Biology

Repair of Strand Breaks by Homologous Recombination

Maria Jasin et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)

Article Cell Biology

DNA Damage Sensing by the ATM and ATR Kinases

Alexandre Marechal et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)

Review Oncology

Hereditary breast cancer: ever more pieces to the polygenic puzzle

Natalia Bogdanova et al.

HEREDITARY CANCER IN CLINICAL PRACTICE (2013)

Review Biochemistry & Molecular Biology

Playing the End Game: DNA Double-Strand Break Repair Pathway Choice

J. Ross Chapman et al.

MOLECULAR CELL (2012)

Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

Review Endocrinology & Metabolism

Estrogen action and prostate cancer

Jason L. Nelles et al.

EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM (2011)

Article Cell Biology

Interaction of the Double-Strand Break Repair Kinase DNA-PK and Estrogen Receptor-α

Senad Medunjanin et al.

MOLECULAR BIOLOGY OF THE CELL (2010)

Article Endocrinology & Metabolism

BRCA1 Regulates Acetylation and Ubiquitination of Estrogen Receptor-alpha

Yongxian Ma et al.

MOLECULAR ENDOCRINOLOGY (2010)

Review Cell Biology

Genomic instability - an evolving hallmark of cancer

Simona Negrini et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)

Review Biochemistry & Molecular Biology

DNA Repair in Mammalian Cells

B. Pardo et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2009)

Article Oncology

The Complex Relationship between BRCA1 and ERα in Hereditary Breast Cancer

Julia J. Gorski et al.

CLINICAL CANCER RESEARCH (2009)

Article Oncology

Oestrogen-mediated phosphorylation and stabilization of BRCA2 protein in breast

J. L. Malone et al.

JOURNAL OF PATHOLOGY (2009)

Article Cell Biology

Estrogen Inhibits ATR Signaling to Cell Cycle Checkpoints and DNA Repair

Ali Pedram et al.

MOLECULAR BIOLOGY OF THE CELL (2009)

Review Cell Biology

DNA repair: easy to visualize, difficult to elucidate

Zita Nagy et al.

TRENDS IN CELL BIOLOGY (2009)

Review Genetics & Heredity

Early events in the mammalian response to DNA double-strand breaks

Lucy C. Riches et al.

MUTAGENESIS (2008)

Review Cell Biology

Regulation of DNA double-strand break repair pathway choice

Meena Shrivastav et al.

CELL RESEARCH (2008)

Article Biochemistry & Molecular Biology

The DNA damage response: Ten years after

J. Wade Harper et al.

MOLECULAR CELL (2007)

Article Biochemistry & Molecular Biology

The DNA damage response mediator MDC1 directly interacts with the anaphase-promoting complex/cyclosome

Gideon Coster et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Oncology

Breast cancer risk is associated with the genes encoding the DNA double-strand break repair Mre11/Rad50/Nbs1 complex

Huan-Ming Hsu et al.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2007)

Article Multidisciplinary Sciences

Estrogen receptor α is a putative substrate for the BRCA1 ubiquitin ligase

Catherine M. Eakin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Cell Biology

DNA damage checkpoints: from initiation to recovery or adaptation

Jiri Bartek et al.

CURRENT OPINION IN CELL BIOLOGY (2007)

Article Pharmacology & Pharmacy

Modulation of the expression of Bloom helicase by estrogenic agents

Takako Iso et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2007)

Article Obstetrics & Gynecology

Breast cancer risk in postmenopausal women using estrogen-only therapy

Heli Lyytinen et al.

OBSTETRICS AND GYNECOLOGY (2006)

Article Biochemistry & Molecular Biology

Estrogen-induced mitochondrial reactive oxygen species as signal-transducing messengers

Q Felty et al.

BIOCHEMISTRY (2005)

Article Multidisciplinary Sciences

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

J Bartkova et al.

NATURE (2005)

Article Multidisciplinary Sciences

Estrogen mediates Aurora-A overexpression, centrosome amplification, chromosomal instability, and breast cancer in female ACl rats

JJ Li et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Biochemistry & Molecular Biology

Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair

JR Zhang et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

Review Oncology

Oestrogen exposure and breast cancer risk

RC Travis et al.

BREAST CANCER RESEARCH (2003)

Article Endocrinology & Metabolism

Development of cDNA microarray for expression profiling of estrogen-responsive genes

A Inoue et al.

JOURNAL OF MOLECULAR ENDOCRINOLOGY (2002)

Article Endocrinology & Metabolism

Identification of novel oestrogen receptor target genes in human ZR75-1 breast cancer cells by expression profiling

M Soulez et al.

JOURNAL OF MOLECULAR ENDOCRINOLOGY (2001)

Article Multidisciplinary Sciences

BRCA1 mediates ligand-independent transcriptional repression of the estrogen receptor

L Zheng et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Article Biochemistry & Molecular Biology

Role of direct interaction in BRCA1 inhibition of estrogen receptor activity

SJ Fan et al.

ONCOGENE (2001)

Review Biochemistry & Molecular Biology

The hallmarks of cancer

D Hanahan et al.