Journal
CELLS
Volume 11, Issue 19, Pages -Publisher
MDPI
DOI: 10.3390/cells11193103
Keywords
T cell; tumor microenvironment; T cell metabolism; anti-tumor function
Categories
Funding
- National Natural Science Foundation of China [82102869, U1804281, 81788101]
- Henan Provincial Medical Science and Technology Research Plan Provincial and Ministerial Joint Construction Project [SBGJ202103083, SBGJ202101010]
- CAMS Innovation Fund for Medical Sciences (CIFMS) [2021-1-I2M-021]
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This review discusses how metabolic pathways influence T cells in exerting their anti-tumor effects and how to remodel these metabolic programs to enhance T cell-mediated anti-tumor immune responses. Glycolysis, carboxylic acid cycle, fatty acid oxidation, cholesterol metabolism, amino acid metabolism, and nucleotide metabolism work together to regulate tumor-reactive T-cell activation and proliferation.
T cells play central roles in the anti-tumor immunity, whose activation and differentiation are profoundly regulated by intrinsic metabolic reprogramming. Emerging evidence has revealed that metabolic processes of T cells are generally altered by tumor cells or tumor released factors, leading to crippled anti-tumor immunity. Therefore, better understanding of T cell metabolic mechanism is crucial in developing the next generation of T cell-based anti-tumor immunotherapeutics. In this review, we discuss how metabolic pathways affect T cells to exert their anti-tumor effects and how to remodel the metabolic programs to improve T cell-mediated anti-tumor immune responses. We emphasize that glycolysis, carboxylic acid cycle, fatty acid oxidation, cholesterol metabolism, amino acid metabolism, and nucleotide metabolism work together to tune tumor-reactive T-cell activation and proliferation.
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