Journal
CELLS
Volume 11, Issue 18, Pages -Publisher
MDPI
DOI: 10.3390/cells11182791
Keywords
noncoding RNA; microRNA-21; cancer; biomarker; RNA therapeutics
Categories
Funding
- National Cancer Center Korea [NCC-2010273, NCC-2010320, NCC-2211640]
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Science and ICT [NRF-2014R1A1A2057118, NRF-2017R1A2B4008257, NRF-2019R1A2C1089145, NRF-2022R1A2B5B01001914]
- Korea Research Institute of Bioscience and Biotechnology (KRIBB) Research Initiative Program [KGM1402211]
- National Research Council of Science & Technology (NST), Republic of Korea [KGM1402211] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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miR-21 plays a critical role in various cancers and has potential as a biomarker for cancer diagnosis and prognosis.
MicroRNAs (miRNAs) are small noncoding RNAs that play an important role in regulating gene expression at a posttranscriptional level. As one of the first discovered oncogenic miRNAs, microRNA-21 (miR-21) has been highlighted for its critical role in cancers, such as glioblastoma, pancreatic adenocarcinoma, non-small cell lung cancer, and many others. MiR-21 targets many vital components in a wide range of cancers and acts on various cellular processes ranging from cancer stemness to cell death. Expression of miR-21 is elevated within cancer tissues and circulating miR-21 is readily detectable in biofluids, making it valuable as a cancer biomarker with significant potential for use in diagnosis and prognosis. Advances in RNA-based therapeutics have revealed additional avenues by which miR-21 can be utilized as a promising target in cancer. The purpose of this review is to outline the roles of miR-21 as a key modulator in various cancers and its potential as a therapeutic target.
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