☆ 4.6 Article

The Nicotinic Receptor Polymorphism rs16969968 Is Associated with Airway Remodeling and Inflammatory Dysregulation in COPD Patients

CELLS (2022)

Related references

Note: Only part of the references are listed.

Review Medicine, General & Internal

Chronic obstructive pulmonary disease

Stephanie A. Christenson et al.

Summary: Chronic obstructive pulmonary disease (COPD) is a global health problem that leads to high morbidity, mortality, and healthcare utilization. Its main causes are exposure to harmful particles, such as tobacco smoke and pollutants. Recent research has shown that various factors throughout the life course increase the risk of developing COPD. Innovations in omics and imaging techniques have provided greater understanding of the disease's pathophysiology, potentially leading to advancements in its prevention, diagnosis, and treatment. This review focuses on recent advances in the epidemiology, pathophysiology, imaging, diagnosis, and treatment of COPD.

LANCET (2022)

Add to Collection

Article Respiratory System

Chr15q25 genetic variant (rs16969968) independently confers risk of lung cancer, COPD and smoking intensity in a prospective study of high-risk smokers

Raewyn J. Hopkins et al.

Summary: In this large-prospective study, the CHRNA5 rs16969968 AA genotype was found to be independently associated with smoking exposure, COPD, and lung cancer (triple whammy effect).

THORAX (2021)

Add to Collection

Article Respiratory System

Extended-culture and culture-independent molecular analysis of the airway microbiota in cystic fibrosis following CFTR modulation with ivacaftor

Gisli G. Einarsson et al.

Summary: Treatment with ivacaftor in people with cystic fibrosis can significantly improve lung function and clinical parameters, and have some impact on the microbiota composition. Improvement in lung function, microbial richness, and diversity post-treatment showed an inverse correlation with inflammation levels.

JOURNAL OF CYSTIC FIBROSIS (2021)

Add to Collection

Article Multidisciplinary Sciences

An innate contribution of human nicotinic receptor polymorphisms to COPD-like lesions

Julie Routhier et al.

Summary: A human coding polymorphism in the nicotinic acetylcholine receptor gene has been found to directly contribute to Chronic Obstructive Pulmonary Disease-like lesions, independent of smoking or nicotine exposure. Experimental studies suggest that this polymorphism can exacerbate lung inflammation and injury from oxidative stress, providing a new therapeutic target for COPD treatment.

NATURE COMMUNICATIONS (2021)

Add to Collection

Article Critical Care Medicine

Mucus Plugs and Emphysema in the Pathophysiology of Airflow Obstruction and Hypoxemia in Smokers

Eleanor M. Dunican et al.

Summary: This study found that mucus plugs and emphysema play different roles in airflow limitation and hypoxemia in smokers with COPD. Mucus plug scores have an independent impact on lung function outcomes, especially in smokers with limited emphysema.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2021)

Add to Collection

Article Microbiology

Extended Bacteria Culture-Based Clustering Identifies a Phenotype Associating Increased Cough and Enterobacterales in Stable Chronic Obstructive Pulmonary Disease

Anaelle Muggeo et al.

Summary: This study found that altered microbiota with Enterobacterales in sputum is associated with pejorative clinical symptoms in stable COPD patients. The research also suggests that further understanding of these findings could lead to changes in the processing of COPD sputum in clinical microbiology laboratories.

FRONTIERS IN MICROBIOLOGY (2021)

Add to Collection

Article Critical Care Medicine

Airway mucin MUC5AC and MUC5B concentrations and the initiation and progression of chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort

Giorgia Radicioni et al.

Summary: This study investigated the relative contribution of MUC5AC and MUC5B to airways disease in COPD, revealing increased MUC5AC concentration as a potential biomarker for COPD initiation, progression, and exacerbation risk. MUC5AC concentration showed greater sensitivity to COPD severity and could be a target for future therapeutic strategies.

LANCET RESPIRATORY MEDICINE (2021)

Add to Collection

Review Cell Biology

The Role of Epithelial Damage in the Pulmonary Immune Response

Rachel Ann Burgoyne et al.

Summary: Pulmonary epithelial cells play a crucial role in lung diseases, with aberrant death and damage contributing to immune response dysregulation, tissue destruction, and abnormal remodeling.

CELLS (2021)

Add to Collection

Article Critical Care Medicine

Necroptosis Signaling Promotes Inflammation, Airway Remodeling, and Emphysema in Chronic Obstructive Pulmonary Disease

Zhe Lu et al.

Summary: This study found that necroptosis is increased in patients with chronic obstructive pulmonary disease (COPD) and in experimental COPD, and inhibiting necroptosis can alleviate smoking-induced airway inflammation, airway remodeling, and emphysema. Deletion of Ripk3 or Mlkl and treatment with qVD-OPh can reduce lung cell death induced by chronic smoking exposure.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Chr15q25 Genetic Variant rs16969968 Alters Cell Differentiation in Respiratory Epithelia

Zania Diabasana et al.

Summary: The CHRNA5 gene SNP rs16969968 is strongly associated with nicotine dependence and lung diseases, potentially contributing to lung disease development by affecting ciliogenesis and inflammatory mediator production.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Letter Respiratory System

CiliOPD: a ciliopathy-associated COPD endotype

Jeanne-Marie Perotin et al.

Summary: The study revealed that COPD patients exhibit abnormal expression of genes related to cilia and ciliopathy, with some genes such as NEK6 and PROM2 potentially contributing to the pathology of COPD. It also suggests the existence of a subtype of COPD, named CiliOPD, which shows characteristics of ciliopathy.

RESPIRATORY RESEARCH (2021)

Add to Collection

Review Biochemistry & Molecular Biology

The nicotinic receptor alpha5 coding polymorphism rs16969968 as a major target in disease: Functional dissection and remaining challenges

Uwe Maskos

JOURNAL OF NEUROCHEMISTRY (2020)

Add to Collection

Review Medicine, General & Internal

Alpha1-Antitrypsin Deficiency

Pavel Strnad et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Add to Collection

Article Respiratory System

Alpha-1 Antitrypsin Deficiency Associated COPD

Charlie Strange

CLINICS IN CHEST MEDICINE (2020)

Add to Collection

Article Respiratory System

Sonic hedgehog signalling as a potential endobronchial biomarker in COPD

Julien Ancel et al.

RESPIRATORY RESEARCH (2020)

Add to Collection

Article Respiratory System

Assessment of stability and fluctuations of cultured lower airway bacterial communities in people with cystic fibrosis

Laura J. Sherrard et al.

JOURNAL OF CYSTIC FIBROSIS (2019)

Add to Collection

Article Genetics & Heredity

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

Nick Shrine et al.

NATURE GENETICS (2019)

Add to Collection

Article Respiratory System

Airway inflammation in COPD: progress to precision medicine

Christopher Brightling et al.

EUROPEAN RESPIRATORY JOURNAL (2019)

Add to Collection

Article Medicine, General & Internal

An Insight into COPD Morphopathogenesis: Chronic Inflammation, Remodeling, and Antimicrobial Defense

Zane Vitenberga et al.

MEDICINA-LITHUANIA (2019)

Add to Collection

Article Critical Care Medicine

Mucins, Mucus, and Goblet Cells

Jonathan Ma et al.

CHEST (2018)

Add to Collection

Letter Respiratory System

Alteration of primary cilia in COPD

Jeanne-Marie Perotin et al.

EUROPEAN RESPIRATORY JOURNAL (2018)

Add to Collection

Review Respiratory System

Role of inflammatory cells in airway remodeling in COPD

Yujie Wang et al.

INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (2018)

Add to Collection

Article Cell Biology

Ciliopathies

Daniela A. Braun et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2017)

Add to Collection

Article Multidisciplinary Sciences

QuPath: Open source software for digital pathology image analysis

Peter Bankhead et al.

SCIENTIFIC REPORTS (2017)

Add to Collection

Review Respiratory System

Global burden of COPD

Jose Luis Lopez-Campos et al.

RESPIROLOGY (2016)

Add to Collection

Article Physiology

Nicotinic acetylcholine receptor expression in human airway correlates with lung function

David Chi-Leung Lam et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2016)

Add to Collection

Review Critical Care Medicine

Gene-Environment Interaction from International Cohorts: Impact on Development and Evolution of Occupational and Environmental Lung and Airway Disease

Adam Gaffney et al.

SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE (2015)

Add to Collection

Article Critical Care Medicine

Genome-Wide Association Studies Identify CHRNA5/3 and HTR4 in the Development of Airflow Obstruction

Jemma B. Wilk et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2012)

Add to Collection

Article Medicine, General & Internal

Small-Airway Obstruction and Emphysema in Chronic Obstructive Pulmonary Disease

John E. McDonough et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

Add to Collection

Article Genetics & Heredity

Genome-wide meta-analyses identify multiple loci associated with smoking behavior

Helena Furberg et al.

NATURE GENETICS (2010)

Add to Collection

Article Genetics & Heredity

A Genome-Wide Association Study in Chronic Obstructive Pulmonary Disease (COPD): Identification of Two Major Susceptibility Loci

Sreekumar G. Pillai et al.

PLOS GENETICS (2009)

Add to Collection

Article Psychiatry

Variants in nicotinic receptors and risk for nicotine dependence

Laura Jean Bierut et al.

AMERICAN JOURNAL OF PSYCHIATRY (2008)

Add to Collection

Article Multidisciplinary Sciences

A variant associated with nicotine dependence, lung cancer and peripheral arterial disease

Thorgeir E. Thorgeirsson et al.

NATURE (2008)

Add to Collection

Article Multidisciplinary Sciences

A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25

Rayjean J. Hung et al.

NATURE (2008)

Add to Collection

Article Genetics & Heredity

Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1

Christopher I. Amos et al.

NATURE GENETICS (2008)

Add to Collection

Article Genetics & Heredity

A Candidate Gene Approach Identifies the CHRNA5-A3-B4 Region as a Risk Factor for Age-Dependent Nicotine Addiction

Robert B. Weiss et al.

PLOS GENETICS (2008)

Add to Collection

Article Immunology

Human T cell leukemia virus type-I Tax activates human macrophage inflammatory protein-3α/CCL20 gene transcription via the NF-κB pathway

Y Imaizumi et al.

INTERNATIONAL IMMUNOLOGY (2002)

Add to Collection

© Peeref 2019-2024. All rights reserved.