4.6 Review

Therapeutic Targeting of NF-κB in Acute Lung Injury: A Double-Edged Sword

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin α5β1 and NF-κB signaling

Juan Pablo Robles et al.

Summary: COVID-19 causes dysfunction of vascular endothelial cells, leading to edema, vascular inflammation, and coagulation. This study reveals that the spike protein of SARS-CoV-2 activates the inflammatory response in endothelial cells through binding with integrin alpha 5 beta 1, resulting in the expression of inflammatory and coagulation factors, as well as increased vascular permeability and leukocyte adhesion. These findings highlight integrin alpha 5 beta 1 as a potential target for treating vascular inflammation in COVID-19.

JOURNAL OF BIOLOGICAL CHEMISTRY (2022)

Article Multidisciplinary Sciences

eNAMPT neutralization reduces preclinical ARDS severity via rectified NFkB and Akt/mTORC2 signaling

Tadeo Bermudez et al.

Summary: Despite encouraging preclinical data, therapies to reduce ARDS mortality remains a globally unmet need. This study found that eNAMPT-neutralizing mAb significantly reduced the severity of ARDS lung inflammation and inflammatory indices in rat and porcine models, supporting it as a potential strategy to reduce inflammatory lung injury and ARDS mortality.

SCIENTIFIC REPORTS (2022)

Article Biochemistry & Molecular Biology

Antioxidants as Therapeutic Agents in Acute Respiratory Distress Syndrome (ARDS) Treatment-From Mice to Men

Andreas von Knethen et al.

Summary: This review summarizes different types of acute respiratory distress syndrome (ARDS) onset, with a focus on the role of reactive oxygen species (ROS) in ARDS development. By studying data from mouse models, this review suggests the potential use of antioxidants as an adjunct to standard ARDS treatment in a personalized approach.

BIOMEDICINES (2022)

Review Biochemistry & Molecular Biology

The Role of Nuclear Factor Kappa B (NF-κB) in Development and Treatment of COVID-19: Review

Monika Gudowska-Sawczuk et al.

Summary: This review paper focuses on the role of Nuclear Factor kappa B (NF-kappa B) in the development of COVID-19 and its potential application in the treatment of SARS-CoV-2 infection. It highlights the important functions of NF-kappa B in modulating the inflammatory response and the increased activation of NF-kappa B in SARS-CoV-2 infection. The modulation of NF-kappa B can result in decreased synthesis of proinflammatory factors caused by SARS-CoV-2 infection.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Immunology

SARS-CoV-2 Spike Protein 1 Activates Microvascular Endothelial Cells and Complement System Leading to Platelet Aggregation

Luca Perico et al.

Summary: Microvascular thrombosis is associated with multi-organ failure and mortality in COVID-19. SARS-CoV-2-derived spike protein 1 (S1) can induce endothelial damage and promote inflammatory and thrombotic processes in the microvasculature, amplified by the complement system.

FRONTIERS IN IMMUNOLOGY (2022)

Review Cardiac & Cardiovascular Systems

Pulmonary pathology of ARDS in COVID-19: A pathological review for clinicians

Sabrina Setembre Batah et al.

Summary: COVID-19 caused by SARS-CoV-2 is a global pandemic, with patients progressing from flu-like symptoms to severe acute lung injury characterized by acute and diffuse inflammatory damage to the alveolar-capillary barrier.

RESPIRATORY MEDICINE (2021)

Review Immunology

Cytokine Storm: The Primary Determinant for the Pathophysiological Evolution of COVID-19 Deterioration

Ruirong Chen et al.

Summary: The COVID-19 pandemic poses a major threat to global health, with cytokine storms being a significant cause of disease deterioration and death, making it crucial to understand the pathophysiological processes involved for effective treatment.

FRONTIERS IN IMMUNOLOGY (2021)

Review Cell Biology

mTORC2: The other mTOR in autophagy regulation

Josue Ballesteros-Alvarez et al.

Summary: mTOR is a crucial kinase with two core complexes, mTORC1 and mTORC2, which regulate cell responses through different pathways. While mTORC1 is known for negatively regulating endosomal biogenesis and autophagy, the role of mTORC2 in autophagy regulation is less studied but potentially complementary to mTORC1.

AGING CELL (2021)

Article Biochemistry & Molecular Biology

mTOR Inhibition Promotes Pneumonitis through Inducing Endothelial Contraction and Hyperpermeability

Xiaolin Chen et al.

Summary: mTOR inhibitors induce PKC-dependent endothelial MLC phosphorylation, contraction, and hyperpermeability that promote pneumonitis.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2021)

Article Biochemistry & Molecular Biology

Spike protein of SARS-CoV-2 activates macrophages and contributes to induction of acute lung inflammation in male mice

Xiaoling Cao et al.

Summary: The spike protein of SARS-CoV-2 plays a key role in viral entry into lung cells and may induce inflammation. The study found that the spike protein provides the main route for viral entry into the lungs and suggests the potential use of an alternative ACE2-independent pathway in the heart and aorta.

FASEB JOURNAL (2021)

Article Biochemistry & Molecular Biology

Ghrelin protects against lipopolysaccharide-induced acute respiratory distress syndrome through the PI3K/AKT pathway

Lishan Zhang et al.

Summary: The study demonstrated that ghrelin protects against LPS-induced ARDS by inhibiting apoptosis, promoting cell migration and tube formation, and activating the PI3K/AKT signaling pathway, thereby stabilizing endothelial barrier function.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

Review Cell Biology

ROCK Inhibition as Potential Target for Treatment of Pulmonary Hypertension

Tadeu L. Montagnoli et al.

Summary: Pulmonary hypertension is a cardiovascular disease caused by extensive vascular remodeling in the lungs, ultimately leading to right ventricle failure. ROCK inhibitors show significant anti-remodeling and anti-inflammatory effects, making them promising targets for PH therapy.

CELLS (2021)

Article Medicine, Research & Experimental

mTORC1 is a mechanosensor that regulates surfactant function and lung compliance during ventilator-induced lung injury

Hyunwook Lee et al.

Summary: The study demonstrates that activation of mTORC1 during mechanical ventilation exacerbates lung injury, and inhibition of this pathway may mitigate ventilator-induced lung injury during ARDS. By inhibiting mTORC1, it is possible to alleviate lung damage caused by mechanical ventilation.

JCI INSIGHT (2021)

Article Medicine, Research & Experimental

Inhibition of protein kinase C beta phosphorylation activates nuclear factor-kappa B and improves postischemic recovery in type 1 diabetes

Satyanarayana Alleboina et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2020)

Review Biochemistry & Molecular Biology

mTOR signaling pathway and mTOR inhibitors in cancer: progress and challenges

Zhilin Zou et al.

CELL AND BIOSCIENCE (2020)

Review Biochemistry & Molecular Biology

Small Molecule NF-κB Pathway Inhibitors in Clinic

Venkataramanan Ramadass et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Multidisciplinary Sciences

Autophagy protein ATG7 is a critical regulator of endothelial cell inflammation and permeability

Mohammad Shadab et al.

SCIENTIFIC REPORTS (2020)

Editorial Material Cell Biology

mTOR Signaling in Metabolism and Cancer

Shile Huang

CELLS (2020)

Review Medicine, General & Internal

Cytokine Storm

David C. Fajgenbaum et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Multidisciplinary Sciences

Superspreading in early transmissions of COVID-19 in Indonesia

Agus Hasan et al.

SCIENTIFIC REPORTS (2020)

Article Medicine, General & Internal

Acute respiratory distress syndrome

Michael A. Matthay et al.

NATURE REVIEWS DISEASE PRIMERS (2019)

Article Allergy

NF-κB pathway and the Goldilocks principle: Lessons from human disorders of immunity and inflammation

Ori Scott et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

Review Medical Laboratory Technology

RNAi therapeutic strategies for acute respiratory distress syndrome

Melissa L. Jagrosse et al.

TRANSLATIONAL RESEARCH (2019)

Review Immunology

NF-κB Signaling in Macrophages: Dynamics, Crosstalk, and Signal Integration

Michael G. Dorrington et al.

FRONTIERS IN IMMUNOLOGY (2019)

Review Immunology

Cell Type-Specific Roles of NF-κB Linking Inflammation and Thrombosis

Marion Mussbacher et al.

FRONTIERS IN IMMUNOLOGY (2019)

Review Geriatrics & Gerontology

mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review

Thomas Weichhart

GERONTOLOGY (2018)

Article Physiology

Autophagy inhibitor 3-methyladenine protects against endothelial cell barrier dysfunction in acute lung injury

Spencer A. Slavin et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2018)

Article Biochemistry & Molecular Biology

Hydrogen sulfide ameliorated lipopolysaccharide-induced acute lung injury by inhibiting autophagy through PI3K/Akt/mTOR pathway in mice

Xiaolin Xu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Review Immunology

Cytokine storm and sepsis disease pathogenesis

Benjamin G. Chousterman et al.

SEMINARS IN IMMUNOPATHOLOGY (2017)

Review Oncology

IP3 Receptor-Mediated Calcium Signaling and Its Role in Autophagy in Cancer

Elzbieta Kania et al.

FRONTIERS IN ONCOLOGY (2017)

Article Multidisciplinary Sciences

Relevance of mortalin to cancer cell stemness and cancer therapy

Chae-Ok Yun et al.

SCIENTIFIC REPORTS (2017)

Review Biochemistry & Molecular Biology

The PI3K Pathway in Human Disease

David A. Fruman et al.

Review Biochemistry & Molecular Biology

mTOR Signaling in Growth, Metabolism, and Disease

Robert A. Saxton et al.

Review Biochemistry & Molecular Biology

30 Years of NF-κB: A Blossoming of Relevance to Human Pathobiology

Qian Zhang et al.

Review Oncology

Focal adhesions, stress fibers and mechanical tension

Keith Burridge et al.

EXPERIMENTAL CELL RESEARCH (2016)

Review Immunology

Regulation of innate immune cell function by mTOR

Thomas Weichhart et al.

NATURE REVIEWS IMMUNOLOGY (2015)

Article Physiology

Autophagy in pulmonary macrophages mediates lung inflammatory injury via NLRP3 inflammasome activation during mechanical ventilation

Yang Zhang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2014)

Article Immunology

The transcription factor DREAM represses the deubiquitinase A20 and mediates inflammation

Chinnaswamy Tiruppathi et al.

NATURE IMMUNOLOGY (2014)

Article Multidisciplinary Sciences

Preconditioning with Endoplasmic Reticulum Stress Ameliorates Endothelial Cell Inflammation

Antony Leonard et al.

PLOS ONE (2014)

Article Physiology

Thrombin selectively engages LIM kinase 1 and slingshot-1L phosphatase to regulate NF-κB activation and endothelial cell inflammation

Antony Leonard et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2013)

Article Cell Biology

The molecular hug between the ER and the mitochondria

Benoit Kornmann

CURRENT OPINION IN CELL BIOLOGY (2013)

Review Biochemistry & Molecular Biology

The complexity of NF-κB signaling in inflammation and cancer

Bastian Hoesel et al.

MOLECULAR CANCER (2013)

Review Critical Care Medicine

PROTEIN KINASE C AND ACUTE RESPIRATORY DISTRESS SYNDROME

Mark J. Mondrinos et al.

SHOCK (2013)

Review Immunology

Protein kinase C signaling and cell cycle regulation

Adrian R. Black et al.

FRONTIERS IN IMMUNOLOGY (2013)

Article Physiology

Inhibiting NF-κB in the developing lung disrupts angiogenesis and alveolarization

Cristiana Iosef et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2012)

Article Biochemistry & Molecular Biology

Regulation of Rela/p65 and Endothelial Cell Inflammation by Proline-Rich Tyrosine Kinase 2

Kaiser M. Bijli et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2012)

Review Physiology

Autophagy in Pulmonary Diseases

Stefan W. Ryter et al.

ANNUAL REVIEW OF PHYSIOLOGY, VOL 74 (2012)

Review Cell Biology

NF-κB, the first quarter-century: remarkable progress and outstanding questions

Matthew S. Hayden et al.

GENES & DEVELOPMENT (2012)

Review Cell Biology

Endoplasmic reticulum-mitochondria contacts: function of the junction

Ashley A. Rowland et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)

Article Biochemistry & Molecular Biology

Inhibition of Autophagy Ameliorates Acute Lung Injury Caused by Avian Influenza A H5N1 Infection

Yang Sun et al.

SCIENCE SIGNALING (2012)

Review Biochemistry & Molecular Biology

ER stress-induced inflammation: does it aid or impede disease progression?

Abhishek D. Garg et al.

TRENDS IN MOLECULAR MEDICINE (2012)

Editorial Material Cell Biology

PI3K-PKB/Akt Pathway

Brian A. Hemmings et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2012)

Review Biochemistry & Molecular Biology

Feedback on Fat: p62-mTORC1-Autophagy Connections

Jorge Moscat et al.

Review Neurosciences

PI3K/AKT/mTOR pathway in angiogenesis

Jayashree Karar et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2011)

Review Cardiac & Cardiovascular Systems

Role of GTPases in control of microvascular permeability

Volker Spindler et al.

CARDIOVASCULAR RESEARCH (2010)

Review Biochemistry & Molecular Biology

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

Goekhan S. Hotamisligil

Article Biochemistry & Molecular Biology

Participation of Mammalian Target of Rapamycin Complex 1 in Toll-Like Receptor 2-and 4-Induced Neutrophil Activation and Acute Lung Injury

Emmanuel Lorne et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2009)

Review Biochemistry & Molecular Biology

Hug Tightly and Say Goodbye: Role of Endothelial ICAM-1 in Leukocyte Transmigration

Arshad Rahman et al.

ANTIOXIDANTS & REDOX SIGNALING (2009)

Review Pharmacology & Pharmacy

Can we predict the effects of NF-κB inhibition in sepsis? Studies with parthenolide and ethyl pyruvate

Xuemei Li et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2009)

Review Pathology

Endoplasmic reticulum stress in disease pathogenesis

Jonathan H. Lin et al.

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2008)

Review Biochemistry & Molecular Biology

Shared principles in NF-κB signaling

Matthew S. Hayden et al.

Review Critical Care Medicine

The endothelium in acute lung injury/acute respiratory distress syndrome

Nikolaos A. Maniatis et al.

CURRENT OPINION IN CRITICAL CARE (2008)

Article Biochemistry & Molecular Biology

NF-κB, but not p38 MAP kinase, is required for TNF-α-induced expression of cell adhesion molecules in endothelial cells

Suja Rajan et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2008)

Review Pharmacology & Pharmacy

Endothelial pathomechanisms in acute lung injury

Nikolaos A. Maniatis et al.

VASCULAR PHARMACOLOGY (2008)

Review Immunology

New regulators of NF-κB in inflammation

Sankar Ghosh et al.

NATURE REVIEWS IMMUNOLOGY (2008)

Article Physiology

Role of NF-κB and PI 3-kinase/Akt in TNF-α-induced cytotoxicity in microvascular endothelial cells

Zhu Zhou et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2008)

Article Biochemistry & Molecular Biology

Evidence for actin cytoskeleton-dependent and -independent pathways for RelA/p65 nuclear translocation in endothelial cells

Fabeha Fazal et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Physiology

c-Src interacts with and phosphorylates RelA/p65 to promote thrombin-induced ICAM-1 expression in endothelial cells

Kaiser M. Bijli et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2007)

Review Cell Biology

The two TORCs and Akt

Prashanth T. Bhaskar et al.

DEVELOPMENTAL CELL (2007)

Article Cell Biology

Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels

Gyorgy Szabadkai et al.

JOURNAL OF CELL BIOLOGY (2006)

Article Hematology

Ca2+ signaling, TRP channels, and endothelial permeability

Chinnaswamy Tiruppathi et al.

MICROCIRCULATION (2006)

Article Medicine, Research & Experimental

NF-κB regulation of endothelial cell function during LPS-induced toxemia and cancer

Tatiana Kisseleva et al.

JOURNAL OF CLINICAL INVESTIGATION (2006)

Article Multidisciplinary Sciences

AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP

Adrienne W. Paton et al.

NATURE (2006)

Review Physiology

NF-κB activation as a pathological mechanism of septic shock and inflammation

SF Liu et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2006)

Review Cardiac & Cardiovascular Systems

Rho GTPases and leukocyte adhesion receptor expression and function in endothelial cells

E Cernuda-Morollón et al.

CIRCULATION RESEARCH (2006)

Review Physiology

Signaling mechanisms regulating endothelial permeability

D Mehta et al.

PHYSIOLOGICAL REVIEWS (2006)

Review Cardiac & Cardiovascular Systems

Two-way interactions between inflammation and coagulation

M Levi et al.

TRENDS IN CARDIOVASCULAR MEDICINE (2005)

Review Immunology

NFκB:: Linking inflammation and immunity to cancer development and progression

M Karin et al.

NATURE REVIEWS IMMUNOLOGY (2005)

Article Critical Care Medicine

Sepsis and coagulation

WC Aird

CRITICAL CARE CLINICS (2005)

Review Cell Biology

Shaping the nuclear action of NF-κB

LF Chen et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2004)

Article Cardiac & Cardiovascular Systems

Superoxide, H2O2, and iron are required for TNF-α-induced MCP-1 gene expression in endothelial cells:: role of Rac1 and NADPH oxidase

XL Chen et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2004)

Review Critical Care Medicine

Pulmonary endothelium in acute lung injury: from basic science to the critically ill

SE Orfanos et al.

INTENSIVE CARE MEDICINE (2004)

Review Genetics & Heredity

Nuclear factor-κB:: its role in health and disease

A Kumar et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2004)

Article Biochemistry & Molecular Biology

Tumor necrosis factor-α induces nuclear factor-κB-dependent TRPC1 expression in endothelial cells

BC Paria et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Pharmacology & Pharmacy

Rac1 and superoxide are required for the expression of cell adhesion molecules induced by tumor necrosis factor-α in endothelial cells

XL Chen et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2003)

Article Critical Care Medicine

Oxidant-antioxidant balance in acute lung injury

JD Lang et al.

CHEST (2002)

Article Cardiac & Cardiovascular Systems

PKCζ regulates TNF-α-induced activation of NADPH oxidase in endothelial cells

RS Frey et al.

CIRCULATION RESEARCH (2002)

Article Biochemistry & Molecular Biology

Mitochondrial protein import: Molecular basis of the ATP-dependent interaction of MtHsp70 with Tim44

F Moro et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Biochemistry & Molecular Biology

Possible new role for NF-κB in the resolution of inflammation

T Lawrence et al.

NATURE MEDICINE (2001)

Review Physiology

Transcriptional mechanisms of acute lung injury

J Fan et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2001)

Article Physiology

Synergistic effects of tumor necrosis factor-α and thrombin in increasing endothelial permeability

C Tiruppathi et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2001)

Review Physiology

Cytoskeletal regulation of pulmonary vascular permeability

SM Dudek et al.

JOURNAL OF APPLIED PHYSIOLOGY (2001)

Article Critical Care Medicine

Nitric oxide and nitrotyrosine in the lungs of patients with acute respiratory distress syndrome

C Sittipunt et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2001)

Article Biochemistry & Molecular Biology

Tumor necrosis factor α-induced phosphorylation of RelA/p65 on Ser529 is controlled by casein kinase II

D Wang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

Article Cell Biology

Protein kinase C-ζ mediates TNF-α-induced ICAM-1 gene transcription in endothelial cells

A Rahman et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2000)

Review Medicine, General & Internal

Medical progress - The acute respiratory distress syndrome.

LB Ware et al.

NEW ENGLAND JOURNAL OF MEDICINE (2000)