A Score to Predict the Malignancy of a Breast Lesion Based on Different Contrast Enhancement Patterns in Contrast-Enhanced Spectral Mammography

Simple Summary Contrast-enhanced spectral mammography (CESM) represents a novel, reliable imaging adjunct for the early detection and management of breast lesions by coupling high sensitivity and specificity. Early diagnosis of breast tumors using this innovative diagnostic method could help in reducing the high number of unnecessary biopsies for breast lesions considered as suspicious by standard radiological examination (such as mammography, ultrasound, and magnetic resonance). Considering its relative recent introduction, there are still no standardized methods for assessing the diagnostic performance of CESM enhancement descriptors. Here, we aim to create a score that takes account four CESM enhancement descriptors able to efficiently predict the malignancy of a breast lesion prior to biopsy. Background: To create a predictive score of malignancy of a breast lesion based on the main contrast enhancement features ascertained by contrast-enhanced spectral mammography (CESM). Methods: In this single-centre prospective study, patients with suspicious breast lesions (BIRADS > 3) were enrolled between January 2013 and February 2022. All participants underwent CESM prior to breast biopsy, and eventually surgery. A radiologist with 20 years' experience in breast imaging evaluated the presence or absence of enhancement and the following enhancement descriptors: intensity, pattern, margin, and ground glass. A score of 0 or 1 was given for each descriptor, depending on whether the enhancement characteristic was predictive of benignity or malignancy (both in situ and invasive). Then, an overall enhancement score ranging from 0 to 4 was obtained. The histological results were considered the gold standard in the evaluation of the relationship between enhancement patterns and malignancy. Results: A total of 321 women (median age: 51 years; range: 22-83) with 377 suspicious breast lesions were evaluated. Two hundred forty-nine lesions (66%) have malignant histological results (217 invasive and 32 in situ). Considering an overall enhancement score >= 2 as predictive of malignancy, we obtain an overall sensitivity of 92.4%; specificity of 89.8%; positive predictive value of 94.7%; and negative predictive value of 85.8%. Conclusions: Our proposed predictive score on the enhancement descriptors of CESM to predict the malignancy of a breast lesion shows excellent results and can help in early breast cancer diagnosis and in avoiding unnecessary biopsies.

Automated summary

Contrast-enhanced spectral mammography (CESM) is a novel and reliable imaging technique for the early detection and management of breast lesions. This study aims to create a score based on CESM enhancement descriptors to predict the malignancy of a breast lesion.